Gut bacteria may hold the key to living longer and healthier lives
Live Forever Club - 21-Nov-2024Metabolic pathways like the pentose phosphate pathway aid healthy ageing
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Metabolic pathways like the pentose phosphate pathway aid healthy ageing
Eating colorful fruits like berries helps you stay healthier and live longer
Scientists used mRNA therapy targeting ATF3 to rejuvenate skin
Funding strengthens their capacity to address unmet needs in immune-related diseases
New cell maps reveal fresh insights into health and disease
A $70m fund takes bold risks to validate ground-breaking ideas and reshape biotech innovation
Their technology reduces costs and accelerates drug development by six months
The funding enables industrial production, clinical trials, and patent filing
DNA changes in fat cells may explain rebound weight gain after treatment
How unhealthy diets are crippling the nation's health, economy, and future
New research shows how regular exercise boosts health, even for those over 40
Understanding these factors may lead to more personalised treatments
A science-backed approach to healthier, younger-looking skin
NVIDIA will support Genesis in optimizing neural networks for 3D data handling
Experts urge global action on diet, exercise, and healthcare access to address this
A revolutionary tool targets specific genes, advancing our understanding of evolution and disease
E-cigarettes will also be offered in certain areas as a secondary option
Seven board members recently resigned after a failed buyout offer
Through the NHS, Open Bionics provides its prosthetics to eligible patients across the UK
Projects include Alzheimer’s research, brain implants, and digital brain modeling for safer AI
Targeting senescent cells may prevent disease progression and show promise
This highlights promising paths for potential anti-ageing therapies
Industry groups call for better testing methods; EU supports stronger checks
Experts highlight the risks involved in trusting private companies with genetic data
Adjusting this axis with diet, probiotics, and supplements could benefit brain health
Mortality decreases gradually with increased strength, suggesting every strength gain counts
Reprogrammed cells from healthy donors give hope to patients with severe corneal damage
Initiatives like The Human Phenotype project aim to improve disease diagnostics and predictions
New findings show a possible role for donor gut lining cells in healing
In trials on mice, the drug reduced tumors, promising new cancer treatments
Foods with high sugar, salt, and processing disrupt metabolism and gut health
Early removal of these cells slows recovery, highlighting their short-term benefits
Signs include sluggish metabolism, inflamed blood vessels, and a weakened gut
Targeting certain proteins might prevent age-related diseases in the future
Potential risks like DNA damage from space radiation require further study
Marks a new chapter for the organisation as it continues its mission to help people live longer, healthier lives
Experts highlight privacy risks for families and advocate stricter controls on DNA data use
DNA stability might be key to unlocking the science of anti-ageing and longevity
Ora biomedical’s high-tech screening could uncover life-extending compounds beyond rapamycin’s reach
This could shape future healthcare and longevity strategies
New funding powers AI-driven implants to revolutionize neurological care
New algorithm reveals your dog’s biological age for better health insights
Aliada’s BBB technology aims to transform CNS drug delivery
New funding accelerates AI advancements for precision medicine
Exploring the promises and pitfalls of a booming beauty trend still shrouded in scientific mystery
Chronic inflammation and fibrosis further damage the heart health
Economic pressures and changing lifestyles are driving a dramatic decline in fertility rates
Elite fitness doesn't guarantee a longer life—contact sports may carry hidden risks
Together, they aim to provide pharmaceutical companies with precise tools for drug development
Social bonds improve resilience and adaptability in various species
Unlocking the secrets of longevity with induced pluripotent stem cells
Leaders caution the ban may fuel a black market, demanding regulated sales
Even small improvements in strength can have significant health benefits
This approach offers new insights into how and why we age
UK is considering enforcing these profit-sharing measures nationally
They aim to use AI-driven capsid design for delivery for complex treatments
Funding speeds U.S. entry and scales production as Orthocell advances global expansion
Scientists enhance brain function and protect against neurodegeneration
The drug 'donanemab' remains available for private treatment in England
Despite recent progress, life expectancy remains below pre-pandemic levels
Anti-inflammatory diets, high physical activity, and healthy sleep patterns work best together
A competition tests top biological clocks to find the best health predictors
Their partnership with Calico focuses on age-related disease treatments
Their Polaris system aims to improve cataract removal precision and consistency
Clinical study showed its accuracy, aiming to replace invasive methods like PET scans
New insights into skin development promise advances in regeneration and ageing
They aim to improve patient care and make clinics more trustworthy and effective
New study finds calorie restriction aids longevity, but genetics may hold the ultimate key
New federated members come from Bulgaria, Canada, Latin America, Nepal, the Nordics, Portugal, and Spain
They use stem cell technology to regenerate the thymus and aim to slow its natural decline
Dario Amodei explores AI’s potential to transform longevity and health breakthroughs
Tests in mice and human cells show long-lasting gene correction
Shift aims to treat diseases like heart issues and arthritis by addressing aging’s root causes
This process occurs mainly at night and may help prevent Alzheimer’s
Despite positive results in monkeys, study lacks baseline data, which raises doubts
Metformin (HR 1.01, CI 0.95–1.07) had a neutral effect on mortality
Lifestyle factors influence epigenetic ageing, highlighting the importance of health
E5 treatment extended lifespan & improves health in ageing rats
New proteasome-activating drugs aim to tackle neurodegenerative diseases and extend healthy lifespan
Targeted cell depletion offers a transformative strategy to treat diseases at their root
Plant-based foods like beans, nuts, and whole grains can help you stay healthy longer
Future of longevity depends on breakthroughs that can significantly slow ageing
Clock.bio secures funding to explore genetic pathways for enhancing healthspan
The findings open new avenues for therapies aimed at slowing the ageing process
A major study shows genetics and immunity are key to the lifespan benefits of calorie restriction
New funding accelerates the development of a novel neutrophil-based solid tumour treatment
Glucose regulation may hold the key to restoring neuron growth
Public health leaders advocate for stronger measures to reduce alcohol-related harm
As therapeutic plasma exchange gains popularity, experts urge caution in the quest for eternal youth
Innovative £120 test could identify 12 common cancers, revolutionizing patient care and saving lives
Using AI and biology to speed up drug discovery for healthier ageing
A successful retinal transplant in a monkey shows promise for treating vision loss
A new breakthrough in nanotechnology offers a non-invasive way to access the cell's genetic material
Support from Didier Coeurnelle enables groundbreaking longevity studies to advance
US researchers unveil a groundbreaking tool using cheek cells to estimate biological age
Recent data reveals a slight decline in centenarians, suggesting a peak in longevity trends
AI-powered handheld system aims to expand robotic precision to routine healthcare procedure
Revolutionizing chronic disease detection through innovative retinal imaging technology
Their survival might even be connected to the time of year they’re born or die
Mesenchymal stem cells may revolutionize healthcare by combating inflammation and ageing
This study may help personalise health strategies for individuals at higher risk
Biotech advances human lactoferrin for better health and longevity
Their abilities help reset biological age, offering insights for human longevity research
You can protect yourself by wearing masks, using air purifiers, and avoiding polluted areas
New research highlights the role of gum disease-related microbes in increasing cancer susceptibility
A pioneering trial reveals the potential of reprogrammed stem cells to reverse type 1 diabetes
Researchers discover a compound that slows ageing by boosting protein maintenance
The ancient genome of the longest-living vertebrate may reveal new insights into ageing
Innovative partnerships aim to develop groundbreaking therapeutics for age-related diseases in cats
Misconceptions and gender biases are costing women's lives
The startup leverages its TFome™ platform for rapid and efficient iPSC programming
Their lead treatment, EA-2353, shows promising safety results for retinitis pigmentosa
Madrid becomes Europe's hub for advancing life extension and healthy ageing
New research from Texas A&M develops nanoflowers to restore cellular energy
This would include warning labels and policies to promote healthier foods
ONL pushes forward with innovative treatment to slow vision loss in dry AMD
Early clinical trials showed safety and effectiveness, with more trials planned for 2025
Groundbreaking research reveals how compressive forces and dehydration drive wrinkle formation
An AI model set to transform drug discovery through cutting-edge molecular predictions
How drug-resistant infections could claim millions of lives by 2050 without urgent action
This lab-grown blood could solve donor shortages and help with frequent transfusions
Their aim is to improve preventive health with personalised solutions
Labour plans to also ban paid online ads and energy drinks for under-16s
New study reveals metformin’s potential to delay brain aging
Innovative platform accelerates drug discovery for metabolic diseases and more
NLRP3 is a part of immune system that plays a key role in chronic inflammation
FAB1 compound reduces ageing markers in cells while FAB15 accelerates wound healing
Cutting-edge AI and laser technology will scale production of personalized regenerative medicines
Aged fibroblasts accumulate proteins internally instead of secreting them
Boosting fat loss and preserving muscle with cutting-edge mitochondrial therapy
Epigenetic clocks show promise for studying ageing in both mice and humans
Food dye reveals hidden organs and veins by making tissues transparent
Xenotransplantation biotech advances groundbreaking pig kidney transplants
A breakthrough protein linked to ageing could lead to new treatments for age-related diseases
Diseases like Alzheimer's and cardiovascular conditions show distinct IgG glycosylation
Biotech firm Bioage plans public debut as it advances promising obesity treatments
German startup decodes the dark genome, advancing precision medicine
Study finds high mental resilience linked to longer lifespan, especially in women
They are paid less, provide more unpaid care, and face higher rates of domestic violence
New stem cell breakthrough offers personalized cancer treatment with less rejection risk
Their work is a major step toward personalised medical treatments
CortexW1 boosts lifespan of worms by 33%, highlighting AI's role in longevity research
Revolutionary approach to reverse ageing process with CRISPR gene editing technology
Safety of rapamycin looks good and lean muscle mass among biomarkers trending towards improvement
New clinical trial hubs to improve patient access to innovative treatments
A promising one-time treatment approach for arrhythmogenic cardiomyopathy
John alfred tinniswood on longevity: simple habits and a positive mindset
Transforming healthcare with non-invasive, drug-free technology
Newly discovered protein may lead to cancer vaccines and advanced DNA repair
Experts say luck and genetics, not lifestyle, are key to living past 100
New method speeds up DNA analysis, unlocking advances in genetics and medicine
The funds will help expand their market reach, particularly into the US
Extending healthspan and lifespan through personalized, preventive care
New funding propels innovative mitophagy-inducing lead compound into clinical trials targeting Alzheimer’s and Parkinson’s
This discovery offers potential clues for preserving hearing in humans
Female athletes generally gain less lifespan benefit from sports
How TPE and IVIG could unlock the fountain of youth
This could lead to improved diagnostics and therapies for frailty
The fungi might play a role in longevity by interacting with beneficial bacteria
She lived in a nursing home and was known for her good health and positivity
Peter Diamandis shares insights on living longer through tech innovation
This trick helps them survive tough conditions and may show new ageing insights
Ancient genes in sea anemones offer insights into ageing and regeneration
Large investments continue, but human research outcomes remain uncertain
A groundbreaking approach to extend life through brain tissue renewal
New treatment aims to reactivate dormant hair follicles, offering hope for those affected by pattern baldness
The findings may explain why health problems often increase at these ages
How lifespan-extending drugs could shape the next biotech boom
The taxes could fund healthier food options for low-income families
This breakthrough offers hope for combating age-related cognitive decline
This merger aims to deliver quicker results and generate substantial revenue
This revolutionary treatment could eliminate the need for lifelong blood transfusions
Hopefully someone will release a proteome-based biological age test for consumers soon
Early antibiotic use may have a negative impact on their health
Now back in full control, Katcher is looking to market its topical application
Regulation is essential to ensure patient safety and data protection
It enhances mitochondrial health, but does not significantly increase ATP
Proposed test costs £230 each, promising significant economic & health benefits
Approach is based on research from UCSF and could transform how diseases are treated
AI could cut preclinical drug development time by half, but rigorous trials are crucial
Vegan lifestyle linked to improved organ health and slower ageing process
Support and healthy eating are crucial for better health outcomes
Eating well and staying active are still the best ways to stay healthy
75% of participants experienced clinical improvement in both pain and function
Advanced technologies like flow cytometry provide deeper insights
Research points to potential treatments targeting the gut microbiome to improve health
Funding will primarily be used to advance therapies focused on muscle growth
Research could significantly boost the UK economy and healthcare system
Research highlights the potential of proteomics in disease prediction
Study also identified that compounds Torin2 and dactolisib extend Drosophila lifespan
PEPITEM supplementation shows promise for extending healthy lifespan
Interleukin-11 antibody shows promise as an anti-ageing treatment that could revolutionise human longevity
Unlocks the healing power of placentas for wound care, anti-aging, and beyond
This raises concerns about manufacturing and regulatory practices in the industry
It lowers inflammatory markers and combats harmful cell pathways
Higher WWI correlates with shorter telomeres, suggesting increased health risks
Funding fuels clinical trials of a lead compound, offering hope for liver disease patients
No severe issues came from the therapy itself, just the procedure or immunosuppression
UN's World Population Prospects 2024 shows recovery to better than pre-covid life expectancy
Some countries have already reached their peak population & others continue to grow
New phase 3b study aims to resolve manufacturing challenges and support regulatory approval
Experts doubt his revival due to tissue damage, but the body was moved to a formal lab
Balanced diets improve gut health, while processed foods harm it
The coronavirus shortens telomeres, harming DNA protection
Company is particularly focusing on less invasive treatments for dry AMD and XLRP
Transhumanists Africa is the latest federated member to join the longevity-promoting alliance
Company is seeking $20M to expand its trial in New Zealand and the U.S
Research offers insights for conservation and human heart health
Lifestyle and chronic diseases play a role, with the brain acting as a central hub
But, senolytic therapy may not be a universal solution for age-related bone loss
Proposes ethical pathways for profit and public trust challenges
With rising obesity and diabetes, experts call for stronger action on sugar and public health policies to keep the nation healthy
Findings indicate that each organ system has its unique ageing trajectory
The therapy is initially available at eight centers across the UK
Blocking cell death pathway rejuvenates livers in mice, offering potential treatment for humans
Potential for advancements in medicine, agriculture, and other fields
Small molecule unlocks youthful telomerase, reversing age-related decline in mice
This could eventually lead to new ways to prevent and treat age-related diseases
With the ongoing increase in human life expectancy, the quest for effective anti-aging solutions is accelerating
The longer the inflammation lasted, the slower the walking speed became
Proved to be superior for weight loss, gut health, and metabolic improvements
Energy expenditure, not just eating less, lead to 20% longer life in mice
This could have implications for developing new therapies
It can also help personalise treatments for telomere-related diseases
This opens up new possibilities for regenerative medicine and tissue repair
This offers a safer, more effective treatment for age-related diseases
This finding could lead to new ways to predict and prevent age-related illnesses
Public support can play a crucial role in accelerating progress
The method has potential for tissue repair and regenerative medicine
It could be a potential supplement for improving cancer immunotherapy
Benefits are seen with high physical activity, healthy diets, and non-smoking
Study focuses on benefits of fruits, vegetables, whole grains, and healthy fats
Canadian company secures $8M to unlock future regenerative therapies through cryopreservation
Protein clumps hold potential for early disease detection, but more research is needed to develop a routine test
Targeting prostaglandin biology could lead to breakthrough parkinson’s therapies
Boosting IRAK-M protein protects retina in the eyes and paves way for potential AMD treatment
Company aims to improve protein production in genetic medicine
Company is developing therapies for Alzheimer's, Parkinson's, and Rett syndrome
However, legal actions aim for prosecution before his death
Its DNA stretches over 100 meters, which is 50 times bigger than the human genome
Findings hint at potential breakthroughs in muscle therapy
This patch also monitors skin health, offering a potential new avenue for treatment
Nanosilicates shown to provide safer, more precise tissue regeneration than current methods
Company's approach involves detecting, correcting, and eliminating damaged cells
The treatment was most effective when combined with a bone-strengthening drug
This technology could potentially improve the quality of life for many older individuals
Drug has shown promising results in animals, offering hope for those with tooth loss
After the transplant, the patient no longer needed insulin or medication
More research is needed, but this discovery offers hope for anti-aging therapies
Programmable mRNA tech promise precise & safe treatment for disease and age-related conditions
Procedure involves cooling the body to -200°C and storing it in a special tank
Company is aiming to increase accessibility and affordability
Leveraging robotics and machine learning to design precise cancer treatments with minimal side effects
Clearly, eating less may not be a straightforward path to slowing ageing
Experts raise concerns about the effectiveness of its methods
Switching the mice back to a standard diet reduced the damage
Their test, MyPhenome, identifies different types of obesity to tailor treatment plans
Such athletes lived an average of 4.7 years longer than the general population
Study highlights a shift towards non-communicable diseases as the major concern
Strong cardiorespiratory fitness significantly reduces the risk of premature death
Novel technique raises hope for studying brain complexities
It may hinder the development of long-lasting protection against future infections
A great summary of 25 speakers who are in various stages of platform building, drug discovery and clinical trials
The hospital hasn't linked his death to the transplant
Random cellular chaos offers new hope for anti-ageing interventions
Therapy offers hope for a potential cure for certain types of hearing loss
The breakthrough could revolutionize drug discovery and disease treatment
Offering hope for longer, healthier lives for future healthcare
SRN-901 increases longevity gene expression and reduces aging activity
Protective gene variants in immunity & cellular cleanup prevent Alzheimer's in old age
Backed by science, this natural compound may be the key to living longer and better.
Research underscores potential to revolutionise approach to healthy ageing
Treatment shows improved blood flow, exercise tolerance and reduced symptoms
Researchers blame government policies for stalled progress and widening health gap
Technology aims to make animal studies more efficient, affordable, and humane
Study emphasises the need to address women's health issues beyond reproductive concerns
Lifestyle choices reduces genetic risk of early death by 62%
This discovery could have important implications for understanding healthy ageing processes
People with Laron syndrome exhibit lower levels of a growth factor associated with ageing
AI-powered platform predicts drugs for age-related diseases with 80% accuracy
Research explain why we become more vulnerable to infections as we age
Successful monkey trials bring hope for safer regeneration therapies in humans
AI unlocks new insights into the complexities of the immune system
This could lead to safer and more effective treatments for genetic diseases
AI-powered protein design models to transform medicine with next-gen therapeutics
Schedule blood tests at the same time of day when tracking biological age over time
Surprisingly, metformin does not reduce death risk
Potentially leading to breakthroughs in managing chronic diseases
Potential tool in boosting immune function and combating the effects of ageing
Longevity AI app offers personalized guidance based on exercise, diet, and sleep data
Complexities spark hope for health benefits beyond telomere length
Technology promises faster identification of molecules for disease treatment
Analyzing blood proteins can improve our ability to identify those at risk for diabetes
Fewer qualified GPs, less consistent care causes shorter lifespans.
Longevity.Technology releases its annual longevity investment report 2023
Innovative approach to protect organs from harmful gut bacteria
Up to $2.5m per project to contribute to cutting-edge research in the field of ageing biology and geroscience
Research aims to extend lifespan and unlock new levels of human health
Machine learning reveals widespread decline in stem cell potency with age
Funding fuels R&D, and collaboration focus on improving diagnosis and treatment options
The company remains focused on its independent cancer drug development
This could transform how we approach diseases linked to cell ageing
The drug targets the lungs and activates stem cells
Specialized protocol aims to address early-stage ALS and advance regulatory approval efforts
John is right that supercentenarians tend to have a long life irrespective of their lifestyle
This investment supports the development of innovative pill-based therapies that use healthy gut bacteria
The supercentenarian leaves behind a legacy of hard work, family, and faith
Researchers improved immune response to new infections and reduced overall inflammation
Company aims to target age-related diseases and liver disease NASH
Scientists injected liver cells into a patient's lymph node, aiming to create a "mini liver"
Experimental stem cell therapy offers hope for spinal cord injury patients
Some bacteria may hold key to lower cholesterol and heart disease risk
Research reveals a potential way to make human cells more resistant to stress
The discovery reveals the body's potential for self-rejuvenation
The gradual buildup of DNA mutations may hold clues on how to combat age-related diseases
The author of Ageless doesn't fall for the faddish approaches to slowing ageing but recommends things that actually work
Funds to advance compounds that target mTORC1 pathway for treating rare and age-related conditions
Personalized bioprints for affordable and more accessible transplants in the near future
Unique metabolism shields hearts in low-oxygen conditions, offering clues to human heart protection
Potential treatment approach to boost immunity and fight disease in older adults
Getting enough sleep is the secret to feeling younger and healthier
New technique delivers more genetic material, paving way for safer & effective gene therapies
Phase 2 trial results show significant vision improvement, plans for FDA approval
Company will use machine learning and gut health science to create custom solutions
Backup code: ageing cells from epigenetic changes could potentially be reset to a youthful state
Managing smoking, blood pressure, cholesterol, and diabetes significantly lowers the risk of heart disease
Alarming trends in preventable deaths like drug overdoses, accidents, and suicides
This procedure marks a major milestone in xenotransplantation
This experimental therapy targets a common metabolic issue in Retinitis Pigmentosa
New study finds social connections affect overall physical health and longevity
Study finds concerning similarities in DNA damage between vapers and smokers
Company aims to revolutionize preventative healthcare using health tracking system
Its record-breaking price raises questions about affordability and access
Company's innovative "liquid cornea" technology shows promise in restoring vision
Pakistan, India, and Burkina Faso are among the most polluted countries
Developing senotherapeutics to target cellular senescence and treat age-related diseases
Event focused on extending quality life years through scientific innovation
Viagra, cholesterol meds & estrogen replacements linked to longevity, but further research needed
This new technology could improve the accuracy of genetic testing
This could change the way we treat liver cancer and address transplant organ shortages
Also predicts a new era of hybrid humans and the potential to reverse aging within the next five years
This innovative therapy uses a collagen microgel scaffold to improve stem cell survival
Prostate, breast, liver, and kidney cancers are driving this increase
Already over 200 organisations have pre-registered - this is going to be exciting to follow
New discovery unveils a molecular fingerprint to predict biological age
Urgent action needed to tackle bias in pulse oximeters, AI devices & genetic tests for fair healthcare for all
Secures $47 million to advance its robotic innovation in soft tissue surgeries
Bodies of younger people could potentially rejuvenate older transplanted cells
The discovery may improve inflammation treatment and anti-ageing interventions
Drug LY3056480 didn't fix hearing completely but 45% participants showed better results
Braingaze to develop apps for ADHD, autism and alzheimer's using eye-tracking technology
The old rats that got young blood lived longer and looked healthier
While modifying immune cell populations, the drugs also increased ageing biomarkers
Accessible only for some: minimum of US$10,000 to invest in longevity breakthroughs
iPSC-based therapy set for phase 1 trials to replace lost neurons and modify disease course
This could lead to long-lasting cholesterol treatments without genetic damages
Study highlights the urgent need for healthy nutrition shift to address the alarming consequences
This is despite spending billions to encourage families to have more children
Genetically-modified stem cells avoid immune rejection, paving way for universal therapies for everyone
Non-viral approach promises long-lasting treatment for AMD patients
Investment fuels its blood-brain barrier-crossing tech for better drug delivery
Its Y100 technology combats hair loss and potentially other age-related issues
CRB1 gene mutation weakens gut barrier, allowing bacteria to invade eyes
Therapy used OSKM genes to potentially extend lifespan and reverse ageing signs
Lowering APOB could potentially delay age-related diseases like Alzheimer's
Experts calling for action to improve basic needs and address inequalities
Telomere research is in its early stages, with much to be discovered
This could lead to a safer and better treatment for type 1 diabetes.
Study highlights the power we have to improve our longevity through everyday choices.
The approach may lead to earlier disease detection & better treatments
Research opens doors for future interventions to prevent muscle loss
Symani's wristed instruments bring steady hands and big ambitions to microsurgery
It reduced blood sugar spikes and overall levels in healthy individuals
Unlocking a new era of comprehensive disease insights and treatment strategies
Leveraging longevity for a stronger economy and healthier society
Exploring how ageing genes impact brain health and disease
Hydrogels mimicking cellular niche could revolutionize the treatment of brain & spinal injuries
This powerful AI could transform how we approach disease research
Fasting improved health markers like insulin resistance and liver fat
Plans to extend the program citywide if successful
The company is developing a drug called UDP-003 to treat the disease
Company aims to transform healthcare by using cutting-edge sugar-based diagnostics
Artificial testicle technology could lead to a better understanding of male reproduction
This could lead to more accurate testing of anti-ageing interventions
Unlike editing DNA itself, this new approach makes temporary changes to RNA
DNA damage accumulated with age worsens gene expression, affecting lifespan-determining pathways
To name a few, moisturizers with acidic pH and emollients with active ingredients can help
All-natural ingredients to positively impact health and mental wellbeing
Single dose injection targets root causes, offering long-term relief & improved quality of life
Their main drug, azelaprag, is like a pill that mimics the benefits of exercise
Research has the potential to revolutionise heart disease treatment in older adults
Pi's accuracy might save healthcare costs and free up resources
They plan to offer quick full-body scans for $500 in a few years
Researchers will work finding ways to live healthier and longer
This collaboration aims to unlock the secrets of ageing and develop new therapies
Making small changes to your lifestyle can have a significant impact on health
Originally used to fight cancer, sound waves surprisingly revive old cells
Their treatment uses implanted cells to calm brain activity and repair damaged networks
The tech expands beyond medicine, demanding new oversight
Early studies look promising, and the company plans to launch its product soon
This low-cost, scalable device could revolutionise spinal cord injuries treatment
Under stress, the composition of gut viruses and bacteria changed in mice
They picked RJVA-001, a gene therapy, as their first clinical candidate
They used special proteins to erase "marks" on DNA that build up with age
Green tea improved gut health and boosted the immune system in mice
Adding fermented foods to your diet is a safe way to support your gut
They used a drug called rapamycin in mice to boost the cell cleaning (autophagy)
Eastern Europe already breathes dirtier air, and the delay would hit them the hardest
Understanding the adaptation is crucial for protecting them on long missions
Financial struggles continue, but CEO Anne Wojcicki remains optimistic
Company aims to shift medicine's focus from illness treatment to proactive health optimization
The research offers safer and more precise ways to treat genetic disorders
It is already used in 15 countries to detect atrial fibrillation and heart failure
It demonstrated a remarkable cure rate, rather than merely offering a treatment
The treated mice showed better health, including improved metabolism and activity
Open to: Individuals, teams, professionals, and anyone with an innovative idea
This £4.2M boost will help them offer this tech more widely in Europe and US
Calorie restriction silences the NLRP3 inflammasome, a key driver of inflammation
The test involves taking a cheek swab and getting a personalised report
This means you might need to focus on specific areas of your health to stay spry
This could impact how much iron we get from food or supplements
It helped mice live longer, look healthier, and have sharper minds
This "physics-guided AI" approach promises deeper insights than current methods
Pandemic takes toll, rural and deprived areas see biggest life expectancy drops
In mice, this therapy was shown to reduce the number of senescent cells
Tiny robots made of DNA can now deliver your medicine straight to the cells
Vesper's main drug, called VES001, is a pill that can reach the brain directly
Report suggests that our focus needs to move from lifespan to healthspan
Sano's software pinpoints the perfect treatment match for each patient
Skipping classes may be as harmful for your health as smoking
Death rate reached 80 per 100,000 people in 2022, the highest since 2011
PAC could personalise healthcare and guide development of anti-ageing therapies
Women have an advantage in longevity genes, especially those related to immunity
Portion control solution to curb your overall alcohol intake
Reading metabolic and immune responses, blood test paves way for early diagnosis & personalized medicine
FAST is precise and works with different cell types and microscopes
Researchers are developing new treatments to turn down the inflammatory response
New therapies combat age-related brain diseases by restoring blood vessel heath
Advances in healthcare and lifestyle changes bridge the gender gap in life expectancy
Company plans to bring their revolutionary Mitopure technology to the world
Patients’ vision and retinal health remained stable after six months
AgeDiff could be a new way to predict disease risk and personalise healthcare
Shown promising results in preclinical studies and early clinical trials
Genetically modified stem cells bypass immune rejection, paving way for universal therapies
The findings pave the way for personalised skincare approaches
Research sheds light on the benefits of calorie restriction
Experts warn that the pandemic's impact goes beyond just a few lost years
Those who ate a vegan diet had lower levels of epigenetic age acceleration
Focused on regenerative treatments for feline gingivitis, canine arthritis, and more
Their AlphaFold engine models proteins could lead to faster and more effective treatments
Eli Lilly and Novartis invest in cutting-edge AI to accelerate the search for life-saving treatments
Bioelectric signals could even promote tissue regeneration
Promising leads for potential anti-ageing interventions in the next decade
This, they claim, is safer and more precise than traditional gene editing methods
These age-jumps, measured by DNA changes, can actually reverse once the stressor fades
Complex interactions with drugs like Rapamycin, Metformin, and SGLT2 inhibitors
SIRT6 activation may be a potential therapeutic target for osteoarthritis
This discovery paves the way for potential anti-ageing therapies
Methylation patterns, measured by epigenetic clocks, offer novel insights
Study reveals two sides to ageing: a programmed decline and a desperate defense
Interplay between these systems suggests potential for targeted interventions
Altos labs with a $3-billion budget pave the way for reversing aging and extending healthy lifespan
Will look at combinations of partial cellular reprogramming, mesenchymal stem cells, serum albumin and deuterated fatty acids
Fauna's AI platform explores animal data to unlock breakthroughs in weight management
London biotech promises revolutionary therapies by replacing faulty genes & flipping gene switches
Quest for people to live healthily for as long as possible will inevitably result in longer lives
Senolytic intervention helps to repair the protective barrier of the eyes
Supplementation reduced the buildup of senescent cells in the arteries of aged mice
Tome Biosciences secures $213m to advance next-gen gene editing
Cellular senescence can be significantly mitigated by a holistic lifestyle
Complex interplay of genetics and lifestyle in influencing heart health
Silicon Valley startup uses personalized data and AI twin to reverse type 2 diabetes and obesity
The method measures increased fluctuations in methylation levels called "noise"
Company's drug targets the root cause of diseases like Duchenne and COPD
Mitophagy-boosting drug candidate VNA-318 preps for clinical trials
It's based on sirtuins research and claims to provide visible results in 14 days
While age ultimately caught up, study demonstrates potential of the novel treatment
BSRA, BGRF and ATLAS join the global campaign group promoting the advancement of healthy longevity for all
The gender-specific effects observed underscore the complexity of ageing
From prevention to participation, a roadmap for healthier, happier, and more productive lives
Sound waves and a special ink to print custom implants and deliver drugs directly to injured tissues
AI-powered data platform empowers early disease detection and proactive care at home
Clinical trials for the ageing drug could potentially be completed in 3-6 years
But don't stress, modern factors like healthcare and lifestyle have a bigger impact than genes
Test could help in the early detection of disease and prevention strategies
Study suggests a more nuanced role of this protein in the ageing
Dinosaur-era pressures may have led to the loss of longevity genes
The drugs target obesity, diabetes, and potentially, human longevity
The method enhances their abilities and promotes wound healing in aged skin
Potential therapeutic approach for mitochondrial and other genetic diseases
Every 5% increase in green space adds 1% younger cells to your body
Natural, innovative approach effectively revitalizes dental pulp and slows infections
10 years of functional age-reversal in 65-80 year olds within the next 7 years... bring it on!!!
A Brit's skeptical take on Blue Zones and the search for eternal life
CpG density may play a role in moderating the epigenetic drift
The goal is to help people stay healthy by knowing their unique ageing process
Bold plan needed to fix NHS, boost research, and end preventable deaths
COVID-19 takes a toll, seniors hit hardest, and Atlantic Canada sees highest jump
Embracing healthier dietary choices can extent life expectancy to some degree
Offers a precise measure of body's biological state and its link to mortality
Offers over 20 innovative organ models for realistic testing and collaborating
The acid eliminates tumours by activating immune cells to combat cancerous cells
A step towards empowering women for better health and quality of life
The research could lead to new ways to slow down ageing in humans
New report exposes shocking inequalities in health, wealth, & opportunity facing older people in England
Science behind your body's ability to live longer, resist infections and survive diseases
Casgevy offers hope for patients with sickle cell disease and beta thalassemia
A revolutionary step towards regenerative medicine, drug testing, and enhanced skin models
Increased vaccination and improved screening are key to achieving the target
Early results show promise in eliminating the need for lifelong statins
COVID-19, drug and alcohol abuse, & suicide fuel a 6-year life expectancy disparity
Offering insights into ageing processes and potential therapeutic targets
Offering hope for individuals with significant muscle damage
Company's pipeline targets inflammation, promote healing, and restore quality of life
Lead program bbHEP01 targets severe acute liver failure, with phase I trial planned for 2025
Company's fasting mimicking technology could revolutionise ageing
The drug works by regulating appetite and reducing cravings
Using AI to screen natural compounds and create novel longevity products
A stepping stone towards personalized anti-ageing interventions
FDA-approved drug kills zombie cells and improves organ function in elderly mice
Opens avenues for novel drug therapies previously deemed impossible
Anastrozole could prevent risk of disease by 50% among eligible women in England
British researchers and startups vie to outpace tech billionaires in the fight against ageing
Effects of alcohol on DNA ageing are not limited to specific demographics
Drugs have the potential to revolutionise the way we treat age-related diseases
Also shields skin from sun damage, environmental toxins, and radiation exposure
A $20,000 prize for innovative approaches to increase longevity sector funding
Company's "cell-free DNA platform" can detect unexplored cell-free DNA fragments
The app helps users boost their energy levels and feel more alive
The novel drugs called molecular gates eliminate disease-causing proteins
Supplementation enhanced fibroblast activity and ECM synthesis
Ring-type blood pressure monitor to revolutionise hypertension management
People with a faster biological age tend to have poorer memory
Model could be used to study the role of telomere length in several diseases
Nanotech's nanoparticles could extend healthspan for everyone
New machine learning model estimates biological age with unprecedented accuracy
Michelle Donelan praises the AI investment, stating it will transform healthcare
Treatment delivers a working copy of a missing gene to the inner ear
MyDogDNAge® measures a dog's biological age and health risks
Jogging or running for at least 75 minutes per week linked to longer telomeres
Factors include productivity gains, technology, and slower economy growth
Some fish species in the lake, like bigmouth buffalo, can live over 100 years
Existing regulations are not enough to protect sensitive habitats from ammonia
Extending healthy years, not just lifespan, as populations age
Advanced biological ageing clock provides a precise evaluation of health & ageing
Company's EA 2351 paves the way for potential vision restoration in patients
Company's innovative approach could revolutionise organ transplantation
Promises a future without animal testing and the need for organ donors
A deep dive into the AgingReG curated database of aging regulatory relationships in humans
Government funding to fuel innovation and growth in the life science sector.
Researchers map thousands of eye proteins, shedding light on ageing mechanisms
Unlocking the secrets of cancer and genetic diseases with nanopore sequencing
HER4 gene types added approximately 2 years to their lifespan
Aspen Neuroscience's ANPD001 aims to replace lost neurons and improve motor function
Gut-brain connection opens doors for early detection and treatment of brain diseases
Company's quest to decode ageing and develop novel therapies gains momentum
CST-3056 targets cognitive decline in Alzheimer’s with a phase I trial in 2024
Platform decodes brain signals, enabling thousands of applications
Microglia conversion sparks a paradigm shift in stroke treatment
Research findings may lead to new treatments for the most common cause of dementia
The event's success fuels optimism for future longevity awareness events
Aims to reach an annual production capacity of 500 artificial hearts
Modest calorie reduction can activate genes for healthy ageing
Structure promotes bone healing in oral and maxillofacial surgeries
Experts warn of the need for guidelines & oversight to ensure safe use of AI in healthcare
Scientists discover a vast array of RNA-guided enzymes in diverse organisms
Insecurity and rising cost of private renting accelerate biological ageing
Could lead to new insights into neurological and mental health conditions
Researchers find link between thymus appearance and lifestyle factors, immune cell regeneration
GC will design and deliver mRNA constructs; Immetas will identify therapeutic targets
Aims for Alzheimer's drugs that target brain's predominant cells, astrocytes
Study reveals new insights into obesity, diabetes, and genetic diversity
Lower levels of glucose, creatinine, and uric acid linked to increased longevity
Enrollment paused, but $1.5 million secured from new partnership
Three gene variants more prevalent in vegetarians, impacting dietary choices
Technology could make mRNA vaccines and therapeutics more effective and safer
MUSA-3, a next-gen microsurgical robot, boosts surgical precision and versatility
Scientists craft lifelike skin to aid chronic wound and burn care
A personalised approach to healing the brain and restoring lost function
Early diagnosis of type 2 diabetes with simple blood test can help you avoid serious complications
Technology could revolutionise the treatment of degenerative diseases
Diagnosis at 30 may cut 14 years off life, but early treatment can extend it
Jpmorgan CEO sees AI transforming healthcare, workforce, and global economy
Company's LINQ platform streamlines drug development for scientists
This may improve immune function for those with thymus disorders and immune decline
The treatment banks youthful hair follicles, clones the cells, and regrows hair
Collaboration of data and discovery to extend healthspan for everyone
Implant continuously monitors cancer and adjusts immunotherapy dose in real time
Offers hope for aHSCT as the future standard of care for 130,000 UK MS patients
Key points from Arkadi Mazin's summary of 5 days of talks by geroscientists and biotech leaders
The poorest will face the hardest hit, with deaths rising four times faster
Investing in the next generation of longevity biotech companies
New AI technologies promise to accelerate scientific discoveries and cure diseases by the end of the century
AlphaMissense is a game-changer in genetic research for human health
Company's INDUCE-seq platform could revolutionise cell & gene therapy efficiency
Technology can successfully measure muscle activity, brain waves, and more
Mitochondria targeting could lead to new treatments for age-related diseases
Game-changing treatments for cancer, cystic fibrosis, and parkinson’s
75% of trusts still use paper, hindering patient safety and efficiency
Lead program targets TRPV4, an ion channel that is involved in several diseases
Human acellular vessel showed better results in vascular trauma repair
Small clinical trial shows treatment can improve breathing and quality of life
Lead antibody shows promising preclinical data & is set for clinical development
The model predicts the risk of chronic diseases before they even show up
Developing "biological software" for effective and affordable mRNA drug design
A single dose of mRNA therapy could rewind ageing and extend lifespan
Resistance training can thicken the dermal layer and boost collagen production
The treatment was well-tolerated with no significant changes in brain function
Stem cell-based embryo models could lead to new treatments for infertility
Fresh fruits, vegetables, and legumes reduce the risk of age-related diseases
Urolithin A rejuvenated blood stem cells in mice, boosting infection defence
Multistem aims to boost organ preservation and transplant success
Liesel the gorilla is now walking again after receiving Stem CellX treatment
Pig plasma therapy could reverse aging in humans
More research is needed to determine the safety and efficacy of senolytics in humans
The test could identify drugs that reverse or slow down DNA damage and disease
Free blood pressure checks to help people identify and manage blood pressure
Novel approach to identify ageing targets and fight age-related diseases
Scientists transfer the longevity gene to mice, extending their lifespan by 4.4%
Funds to help AI-discovered drugs enter clinical trials and expand its pipeline
Funding will be used to test the patch in geographic atrophy patients in phase 2b trial
Ageing and obesity are key drivers of the rise in cases
New reprogramming method addresses epigenetic challenges & sets a standard for cell therapy research
AI-estimated age based on chest radiographs could be a biomarker of ageing and disease
PF4 from platelets enhanced learning and memory in both young and old mice
A breakthrough approach to make enamel by mirroring gene pathways in natural tooth formation
Organ on a chip may be more successful than mice models in translating science to the clinic
Universal clock based on methylation profiles to accurately predict age in all mammalian species
Three natural compounds identified, paving the way for new treatments
Many neglected proteins/genes have essential function, finding out may accelerate future research
FDA approves Neuralink's brain implant, patients can now sign up for trials
By editing RNA instead of DNA, the company aims to treat multiple undruggable genetic diseases safely
Study results offer insights on future drug discovery for disease related to muscle ageing
Study finds strong link between social deprivation, ethnicity and sleep quality
Researchers achieve 150-day retinal cell growth, but biocompatibility uncertain
New treatment approach could be more effective in lowering the risk of serious side effects
Details magic of converting stem cells to any cell type and transplanting them to treat age-related conditions
Deglycating enzymes could offer an affordable, effective, and non-invasive treatment for presbyopia
Planning to test its therapies in dogs next year, with human treatments expected in the near future
Tissue engineered blood vessels might replace bypass surgery to treat heart disease in future
Bill Gifford interviews João Pedro de Magalhães, professor of molecular biogerontology at the University of Birmingham
Vaccine not only reduced inflammation, but also improved behavior and awareness in mice
Hormonal changes during pregnancy and menopause may speed up the ageing process
T cells effectively fight pathogens using energy fuel as ketones, which are typically produced in fasting
Overall dropped by 0.42 years for men and 0.49 years for women in 2022 - second fall in a row
VitalOne reports 50 lab tests in just 20 minutes and improves accessibility for clinicians & patients
Innovative BIOVANCE single- and three-layer products for ocular surface disease treatment & surgical support
Infusion of youthful blood increased lifespan by 5% and improved age-related gene alterations
Large increases in people with anxiety, depression, chronic pain, and diabetes
Improvements seen in muscle size and collagen deposits in older people with atrophy
Multipronged T-cells recognize multiple target proteins and attack cancer in many ways
Identifying genetic preferences may hold the key to personalized nutrition and healthy eating
Novel method for precise estimation of biological age and disease risks with a single blood sample
Lab-grade kit that measures 17 biomarkers of health & fitness with a finger-prick blood sample
AI-powered research platform to accelerate the processes in drug discovery and development
Its polymer-supplemented culture system enables cell expansion without harmful mutations
Unregulated clinics worldwide are offering unproven, dangerous treatments, exploiting regulatory loopholes and misleading desperate patients
David Sinclair and team discovers potential new approach to treat age-related diseases and promote healthy aging
Multistem combats inflammation to improve trauma recovery
Recommended by Aubrey de Grey, Ray Kurzweil, George Church, Michio Kaku and many more - they can't all be wrong!
Lab grown tooth could soon become a reality - provides hope against painful root canal treatments
NBTXR3 to enhance the effect of immunotherapies; plans for phase 3 trial in head and neck cancer
Despite the limited improvement, gene therapy offers hope for future breakthroughs in restoring vision
Highly accurate enzyme-based approach to advance the ability to read, write and manipulate DNA
Ground-breaking technology to advance the development of a bio-engineered thymus & lung disease treatments
Selectively inhibits problematic free radicals - potential breakthrough in treatment of chronic diseases & ageing
WormPicker takes on time-consuming tasks including inspection, movement between petri dishes and genetic crossing
Heavier electric vehicles raise concerns from increased tyre wear pollution despite resolving exhaust emissions
Aims to spread its life-enhancing solutions (including collagen booster) further across the globe
Recombinant human collagen based fillers help advance the field regenerative aesthetics
Insights on the evolution of ageing and may help advance regenerative medicine
To prevent major diseases while making patients’ lives easier & reducing pressure on GP services
New study finds people with high access to green spaces were 2.5 years younger in biological age
Bemdaneprocel shows positive phase I results, advances to Phase II trial in early 2024
Novel recombinant protein to manufacture biologically fit cells by safely lengthening telomeres
A study of Tanzania's Hadza people reveals over a thousand new gut microorganism species
Plans to leverage exclusive Attobody nanobody platform to develop innovative treatments in immunology and oncology
Biotech leverages insights from immunology and cardiology, aiming to dissolve arterial plaques with their flagship asset, BRB-002
Many people believe lots of clinical trials of novel therapeutics targeting mechanisms of aging will start up in the next few years
Paves way for potential medical research, organ manufacturing and disease treatment advances
Zoltan Istvan argues that technology will fundamentally shift the equation
Artificial intelligence identifies herbal compounds to safely eliminate senescent cells
Improves in situ tissue and organ regeneration, promising future applications in drug delivery and custom prosthetics
Innovative technology combines synthetic biology, genomics, and machine learning to transform the way diseases are diagnosed and treated
Strategic investment aimed at harnessing the power of collaborative innovation and AI in the pursuit of groundbreaking therapeutics
Metformin may function as an anti-inflammatory and potentially reduce the viral load of SARS-CoV-2
Combination of factors that rejuvenate stem cells holds promise for aging and muscle-wasting diseases
Exceptional longevity and resistance to cancer holds potential implications for human health and ageing
Ability to carry vast amounts of DNA and other molecules promises substantial advancements in gene and cell therapies
Epigenetic breakthrough offers hope for anti-aging therapies, harnessing the power of naturally occurring peptide
UBX1325 showed disappointing results in phase II macular degeneration trial - further analysis is required
Nine innovative projects, spread over seven US institutions, set to receive funding
Urges individuals with resources and a desire to contribute positively to humanity to invest in the longevity industry
Key points from more of the excellent speakers at the summit
Better understanding of composition and changes of gut microbiome could lead to potential interventions
Telomeres become sinks of irreparable damage - antisense oligonucleotides could potentially provide a fix
Building a saliva-based epigenetic biomarker for systemic chronic inflammation (SCI)
Aims to cure presbyopia by restoring elasticity of the lens & inhibiting ageing process
Extensive analysis reveals an initial benefit to longevity that diminishes, then reverses, over time
Explained the production and mechanisms of Urolithin A, and trial results of Timeline's Mitopure
A quick introduction to the preventative maintenance approach, LEV Foundation and Robust Mouse Rejuvenation
Reprogramming the epigenetics of a cell could reverse a significant amount of the functional decline that we see with age
Calls for safe and ethical use of LLMs to protect patients and public health
VitaDAO has already funded 17 projects - including research areas not supported by traditional government agencies
Glycans are the most neglected molecules of cellular communication
The course of organ ageing can be mapped and predicted
Updated DNA map opens doors for more inclusive and effective medical treatments
Will use its drug discovery platform to further development of lead compound, IA101
Groundbreaking method poised to revolutionise regenerative medicine
Novel theory of biological systemic ageing suggests epigenetic ageing is inevitable
Nir Barzilai brings his expertise to boost the company's mission to extend healthspan by targeting age-related diseases
Semaglutide tricks your stomach to feel fuller and more satisfied; may be ineffective after withdrawl
Machine learning successfully identifies promising senolytic compounds to target ageing and age-related diseases
Organisations share a common mission of healthy longevity for all through scientific research
Stealth development now public and aiming for multi-million dollar turnover by end of year
Further studies required to better characterize the association between gut microbiota and its metabolites
Oral formulation offers a simpler way to restore gut balance & combat recurrent C.diff infections
Potential for manipulating fibroblasts to improve heart healing and regeneration after heart attack
The report sets out an ethical framework and recommendations for research and innovation related to ageing
Helping the body recover from stress could contribute to increased longevity
Corporate shift towards ophthalmology puts senolytics head-to-head against existing treatments
Epigenetic reprogramming restored in primates, now paving way for human trials
2 month life extension is equivalent of giving a 60 year-old human an extra 6 years of healthy life
Apply now to showcase your translational longevity research and win CHF 50,000
Calorie restriction may extend lifespan by improving the quality of gene transcription
Even without rejuvenation treatments, expect to see maximum lifespan record broken by 2060
Nanorobots make the process cost-efficient and fast, with same level of accuracy compared to tradition method
A youthful gut microbiome may contribute to enhanced longevity and overall health in people living past 100
Aims to extend human healthspan and promote impactful lifestyle changes
High access to non-alcoholic alternatives may notably reduce alcohol purchases
Scans to know the eyeAge can provide an actionable evaluation of gero-protective therapeutics
The weed could serve as an all-natural skin care product if turns out beneficial
Larger sample sizes will further refine their predictability and improve their use case
The type of exercise can effect autophagy in humans, that in return can be an anti-aging strategy
Associations between telomere length and endophenotypes could help treat neurodegenerative disease
Looking to invest in the longevity industry? Stakes from $100 available on Wefunder platform
Therapeutics to boost regulation of protein homeostasis may be beneficial across multiple organs and pathologies
Age-related increase in inflammatory markers p16 and IL-6 was not observed in endurance athletes
Senescent cells have become one of the most promising targets for healthy aging research
Rubedo is planning first-in-human studies in multiple skin indications driven by chronic inflammation
Machine learning analysis of millions of biopsy reports has potential implications for disease risk and treatment
Driven by income inequality and resulting larger fall in poorer groups
Supplementing with the amino acid D-serine may reverse some anti-ageing effects
Fully automated Intelligent Cell Processing System to manufacture potentially life-saving treatments
Is involved in many longevity companies ranging from improving gene therapy delivery to supplements
A new weapon that could give doctors an entirely new way to treat heart failure
Original study was subject to bias due to exclusion of participants who progressed to multiple therapies
Scientists are working to bring these new rejuvenation biotechnologies of senolytics to aging humans
People are less likely to die the more often they socialise
Tissue-specific gene therapies & rejuvenating factors to extend lifespan and combat age-related diseases
Multilayered architecture resulted in physiological and behavioural improvements. Could it help regenerate the ageing brain in future?
Lower the metabolic rate and body heat, longer the lifespan, but has double-edged sword nature to it
Analysis of CALERIE trial shows a slowing down in the pace of ageing, but no immediate reduction in biological age
China’s population could peak at 1.4bn in 2025 then almost drop by half by the end of the century
Thymmune aims at developing therapies to treat several autoimmune diseases and organ transplant tolerance
Epigenetic medicine approach avoids the pitfalls of traditional CRISPR method of gene editing
No drug candidates yet, but great to see investors willing to support a broad attack on ageing
Higher levels of glutathione better at muscle repair while low levels of the same are bad at it
Chronic inflammation is lurking behind many age-related diseases, but also offers up many targets to reduce it
Not just the number of hours but also the quality of sleep is important to enhance your wellbeing
Longevity Technology interviews CEO Melanie Goldey
Blood tests for proteins encoded by telomeres could give information of biological age and cancer
Study identifies biological mechanisms including efficient DNA repair, no thymic involution and dampened inflammatory response
A revolutionary approach in regenerative medicine that could improve quality of life in patients
Those running geroprotective trials, academic researchers, clinical trial could use Cell tree rings
A strong genetic correlation between healthy diverse gut microbiome and healthy ageing was found
MSCExos shown to improve osteoporosis by promoting osteoclast cell proliferation and formation of blood vessels
The peptide-3D printing ink could benefit regenerative medicine and medical research enormously
Mitochondria dysfunction is linked to several ageing-related diseases, including neurodegeneration, so a big potential market
Shown to work at a cellular level in humans, too, so a therapeutic could be developed soon
The researchers will not only focus on CVD or cellular aging but the optimal point of intervention
Arthritis drug named anakinra found to reverse ageing effects in blood in mice
12 months of IF results in a range of biomarker improvements, but no significant reduction in inflammatory markers
Novel therapy killed some senescent cells, rejuvenated others, without harming healthy cells
Two promising techniques: mRNA delivery through CNP-created EVs and microneedles for EV application
With a global ageing population, the benefits of delaying ageing, even if slightly, are immense
Open gene database simplifies the search for potential aging therapy targets
Revolutionary discovery offers new hope for heart failure treatment
Healthy mutant gene can reverse the decline of heart performance in older people
Another reminder of the amount of research, with multiple approaches, about to go into clinical trials
Experts debate on risk versus enjoyment, however, people must be aware of the risks associated with long-term alcohol use
Most genes regulating cellular rejuvenation were not related to the increased occurrence of cancer
The study highlights the diversity of microbiota and their importance for human health and fitness
Modifying gut microbiota with antibiotics reduced inflammation and tau-linked damage
Round 1 testing rapamycin, senolytic, HSCT & mTERT - could start seeing interesting results within 6 months
MicroLED tech could revolutionize the display industry but is still in its early stages of development
Identifies a new target for ageing therapeutics - maintaining the abundance of long RNA transcripts
Had success in reducing muscle atrophy and discovered novel class of molecules to target cognitive decline
Soon there will be a test to check what the best diet is for your individual microbiome
Cells fundamental quality control mechanism to safeguard the nucleus-promote longevity and fertility
SIRT6 has a vital role in cell metabolism which could lead to therapeutics for controlling senescence
Grand plan includes creation of imaging datasets, new tools, techniques, and biomarker panels
Targeting and eliminating mutated mtDNA by subjecting it to autophagy with rapamycin been successful
New antibody approach aims to slow or halt Huntington’s disease progression
Further studies to examine the phenomenon for age-related illnesses among former players
Size of various cells (including red blood, adipocytes, brain, heart) is seen to increase with age-related diseases
Base editing can soon be a part in taking control of our genomes to fight genetic diseases
Epigenetic reprogramming restores the production of collagen and elastin
The study outlines a list of genes and genetic variants for future study of common diseases
Gut bacteria indirectly produce hormones that influence the brain and can cause depression
This one-off treatment could nullify the complications that you get with chronic medications
Plan is to build a generic platform then work with major pharma companies to take them to market
How senescent neurons lead to Alzheimer’s disease, effect on removal and drugs needed for therapy
The new PASTE tool replaces faulty genes in a safer and more efficient way
Next-generation proteomics technology to accelerate drug discovery and development
The midlife study showed that the cognitive decliners age faster
A restitution hearing will decide how much she must repay
Targeted gene-delivery hold potential in replenishing the skins key protein, to treat fine lines
Breakthrough approach to regenerate new cochlear hair cells that enable hearing
Biological alchemy by leprosy bacteria-converts one type of bodily tissue into another
Funding will accelerate development of autophagy-based treatments for challenging diseases
Advances in AI is great, but this sort of automation is what will create the data it needs to find new longevity drugs
We need much more public education that living longer, healthier lives is just round the corner
BDNF-TrkB pathway shows a lot of promise in lowering senescent cells in older organs
It may help treat other conditions like ulcerative colitis and improve cancer therapy
The weaker the grip strength, the older is your biological age
Mutations in a telomere binding protein provide a new approach to treat melanoma and other cancers
This approach did not kill the senescent cells instead, it was senomorphic
Its a fully integrated approach for developing biologics for chronic and age-related diseases
A breakthrough treatment for people requiring blood transfusions in near future
The company aims at treatments for a range of diseases associated with ageing and disabilities
Many conditions could be improved by removing signalling that prevents cells operating at their best
Cells are already in the right place, just need the right kick to help repair the body when needed
Partial reprogramming extends healthspan and lifespan by single or lifelong treatment
Early but promising finding that epigenetic changes alter the growth of cancer cells
Kizoo is focused on rejuvenation biotech so it must see potential in normalizing CDC42 activity
Shared methylation patterns across mammals showed an association between ageing & development process in evolution
There is a strange overlap in interests between crypto people and longevists - and long may that benefit the industry!
Hair cells generated in vivo, potentially promising to reverse hair loss disorders and baldness
Some really exciting developments with quite a few in clinical trials
The study is a caution for scientists engaging in self-experimentation with senolytics
Skin microbiome emerged as the primary reservoir for infection risk associated with frailty
Only 4 out of 31 countries studies have seen their period life expectancy recover since 2020
Cyberdontics-robot cuts the tooth and fabricates a prosthetic at the same time-efficacy and speed
Terray’s novel microarray technology, combines wet lab and computer-driven drug development
Cell therapies aiming not only to correct the genetic defect but also repair and heal the muscle cells
If successful in humans it would improve the outcome of many age-related diseases
Aims to treat age-related diseases using advanced cellular reprogramming technologies
Differences in biological aging between men and women - frequent smoking and larger body size of men
Will look at whether health and ageing improves with calorie restriction or intermittent fasting
More than 90% of drugs safe and effective when tested in experimental animals fail in human testing
Cleara’s novel FOXO4-based treatment approach-ability to eliminate biomarker-positive scarred cells
Psychological component should not be ignored in aging studies as they impact on biological age
Looks like it will act as an interface between longevity researchers and clinicians
Founders are excited to find the impact when software intersects science
Initially targeting ischemia-reperfusion injury, TMT has potential to treat multiple age-related diseases
Pretzel targets genome correction, genome expression modulation and mitochondrial quality control
Self-experiment results- detrimental due to frequent doses or simply bad combo
New firm launched by 3D Systems to advance drug discovery and testing process
Plasma concentrate alters methylation clock reducing biological age
Ichor Life Sciences leads the investment to advance anti-glycation therapies
Higher sleep age reflected in increased sleep fragmentation, it may be a marker of future health
what this means to humans? - a possibility to treat overwhelming aging disorders
US records the lowest since 1996 and UK fell for the first time in 40yrs
A solution to reduce both antibiotic usage and antimicrobial resistance
TPE causes systematic rejuvenation in human body by influencing multiple factors
They aim to identify aging pathways and develop new drugs and biomarkers
Camera on each petri dish captures healthspan of many worms simultaneously
Eliminating senescent cells rejuvenates the heart's capacity for regeneration in mice
Microneedle-based hair treatment substantially more effective than topical application
Let's hope their research is either successful for the company or its successors
Mayo Clinic advance regenerative technologies from discovery science to early phase clinical trials
Statistically significant treatment effect for both BCVA and CST was seen at both 12 and 18 weeks
Whole genome sequencing-necessary to validate Stem cell lines used for therapy
Vitalunga to usher the novel drug for hepatocellular carcinoma clinical trials
Addresses challenges like phenotype list compilation and associated genes
VascVersa is committed to regenerative medicine for people suffering from ischaemic diseases
Overlap between the hibernation genes and the longevity genes links hibernation with longer life
Infusions of young blood plasma into mice, does not increase their lifespan
Re-engineered native bacteria serve as chassis to introduce therapeutics into the gut
SIRT6 Activator is a safe way to repair the genetic damages that may occur due to aging
Alcohol consumption causes telomere shortening, leading to several age-related diseases
Accelerated biological aging associated with lower odds of living healthy and longer
Sarcopenia drug trial shows no evidence of toxicity or safety issues
Poorest 10% of patients are now five times more likely to die with lung disease than the wealthiest
ForSight Robotics main goal is to democratize sophisticated eye treatment procedures globally
Trial results were positive but cautioned the use until proven safe and effective
Complex I production temporarily halted in quiescent oocytes, promoting fertility
Effectively communicating to investors will translate an ideology into a social benefit
Mitochondrial transplant raise energetics of the body, so it can withstand longevity treatments
Aging associated retinal disorders linked to loss of protective protein
Understanding how Y chromosome may contribute to age-related diseases can help prevent them
A target for Alzheimer’s disease therapy may lie in plasmapheresis or blood dialysis
Investigation of ability of metformin, a diabetic drug to slow the process of aging
Positive results in lab tests suggest the drug may improve lifespan and life quality
Endogena's gene-independent treatment has shown advantages in retinitis pigmentosa
Soft yet tough biohybrid composites similar to lifelike skin may have productive potential
APOE and FOXO3A had significant impact on longevity, but environmental factors also determine the fate of health while ageing
Not adding extra salt to already prepared foods could be a healthier option
Helical structure of heart muscles helps understand the functioning of heart
Mitopure can improve mitochondrial health and counteract age-related muscle function decline
CRISPR genetic editing tools may be helpful in genetic repair
ECM proteins play significant roles in hPSC adhesion, growth & cardiac differentiation
Upregulation of VEGF-A could be a potentially effective anti-aging therapy
Oxidative DNA damage induce rapid senescence compared with shorter telomeres from repeated cell divisions
Stem cells in human urine have major advantages over stem cells from other sources
Automated design and execution can increase efficiency and speed of research
The acquisition strengthens the Fujirebio Neuro Center, making it a leading hub in diagnostics
This breakthrough could lead to new treatments for cancer and Alzheimer’s
Also announces move to Buck Institute for Research on Aging
Stemin and YAP5SA notably restores normal cardiac pumping in mice
Metabolites induce autophagy, stimulate cellular regeneration for healthy ageing
Developing a software platform that uses quantum computers to accelerate the discovery of new drugs
Funding might allow RNA-based rejuvenation tech to enter ex vivo lab tests
Mitochondrial dysfunction & stem cell exhaustion accelerated the epigenetic clock, but senescent cells & telomere length did not
No mention of the Conboys, but it looks like it's based on their plasma dilution research
Positive physiological factor extends life expectancy of women beyond 90
Considering funding a $100 million age reversal X Prize and the TAME(metformin) trial
Lifestyle improvements- a positive impact on health despite chronic health conditions and older age
Staring at gadget screens at night affects circadian clock and in turn lifespan
Big data combined with laboratory automation - the pace of drug discovery is about to take off!
Radiation-induced damage may lessen by removing senescent cells but senolytics may not reverse the damage
Lento Bio research into molecular aging damage by accelerating clinical assets
Largest height study ever: being tall increases risk of peripheral neuropathy, lowers heart risk
Treatments targeting faster-growing stem cells & low-quality blood cells can promote healthy ageing
Cost-efficient whole genome-sequencing at a price of $1/Gb using NGS
Leaves DNA sequence unaltered while retaining the ability to specifically home
Pluripotency network can have negative and positive lifespan effects
Could eventually lead to treatments that reinvigorate immune cell production
Chloroquine significantly interferes with the fundamental mechanisms behind autophagy
in vivo analysis in mice confirms the imaging results against p21 biomarker
Oligodendrogenesis and memory function in the aged brain can be improved by young CSF
PhenoAge and GrimAge show epigenetic aging has downstream biological consequences
Multistem shows promise in secondary measures but misses key endpoint
Treatment used proprietary CMV vector which is able to deliver multiple genes into the nucleus
AntiBERTa's advanced AI model unlocks deeper insights into antibody structure and function
In yeast, increasing Tom70 delays ageing related mitochondrial dysfunction
Mitopure will be offered inside Nestlé Health Science products
Combined approach surprisingly eliminated the negative effects of individual treatments
The one thing I hope he's wrong about is that it won't happen in his lifetime - we just need some exponential oomph!
Treatment options for diseases of aging - from the makers of metabolic switch
Lifespan of mice greatly extended even when treatment only started at the equivalent of 56 years old
Gene modification in bacteria using CRISPR array provide direct information of active gut genes
We know exercise keeps people healthier and this may be just one of the underlying mechanisms
Plasmalogen supplement reversed ageing signs in mice; might as well keeps you young
Le Calvé will chair the Scientific Advisory Board and the Management Committee
When it comes to lifespan, you cannot blame 100% on genetics, just 10-30%
Trials underway to test the safety, but affordability and acceptance of gene therapy are major concerns
Triple the effect seen over simply restricting calorie intake
Gut microbiome dictates and decides the health of your gut, eyes, and brain
Light-driven artificial nerve could one day be used for medical devices or implants to cure diseases
Opens way for personalized therapy, drug testing, and clinical extrapolation
Targeting age-related diseases, the company's pre-clinical compounds to progress to the clinic
Your cells as your own "organ-on-a-chip" model for heart disease
Aeson could prolong lives of patients awaiting a human heart transplant
Epigenitic and brain aging markers provide insights on accelerated cognitive decline
Bioengineered implanatable tissues can repair or replace diseases organs
Female life expectancy in poorest areas was 7.7 years lower than richest areas of England
Another company enters the cellular reprogramming race - hopefully at least one will cross the finishing line
Shorter lived animals have higher rate of mutations - could explain lower rates of cancer in larger mammals
mRNA technology-reset aging to extend health span and improve quality of life
Transient reprogramming is progressing fast - how long before the first skincare product is launched?
Lorna Harries details significant breakthroughs at fourth annual Longevity Leaders World Congress
Initially targeting stiffened arteries in cardiovascular disease, this could have wider implications
Lomecel-B targets homing and microglia recruitment rather than differentiation
$180M fund will support research on cellular reprogramming, autophagy & plasma-inspired therapeutics
Mapping the brain and creating charts could be used as a helpful clinical tool for other clinicians, psychiatrists and researchers
WHO calls for the immediate transition from fossil fuel use to clean energy
Innovative tech to make self-administered therapies easier and more accessible
Currently exploring the SIRT6 potential with University of Rochester’s Aging Research Center
Positive results in clinical trials provide hope for conditions that currently have no specific treatments
The approach may make testing more accessible for those without specialist healthcare access
Great to see the concept of reversing aging becoming a mainstream ambition - it hasn't always been that way!
Funds will be used to develop enzymes that repair collagen and reverse ageing or disease
Dasatinib+Quercetin restores a-klotho protein, which could combat ageing and disease in older people
Exception was for people with a cognitive impairment, study by Newcastle University shows
Organ preservation and life extension is possible when humans could also hibernate
Biological age differs from one organ to other, suggesting practical use of multiple clocks
Yamanaka factors restored youthfullness in aged cells, raised hope for new anti-ageing therapies
Have you been taking rapamycin supplements recently? Please consider contributing to this study.
Treatment was successful in mice, and now gears up to treat paralyzed humans
Different flavours of rapalogs targeting different age-related conditions
And by longevity it means "substantially increase health span or life span" - apply now!
UK charity seeks funding opportunities for better treatment and research
Approaches include senotherapeutics, stem cells and mitochondria. Eye disease is a common first target.
Painless bone regeneration with a faster, easier and effective approach
Paving the way for bioprinted livers and personalized drug screening for liver diseases
Protein produced by macrophages was identified as a key player of calorie restriction
Appears to be ahead in the race as already started human trials
Both are leading first generation longevity treatments - even better if they strengthen each other
dNovo converts any cell to hair stem cells, and have already grown hair in mice
Maybe a longevity drug within 5 years, but still lots more research needed into process of ageing
Libmeldy is life-saving gene therapy now available for use in England
Building from Deepmind's AI research, Isomorphic promises medical breakthroughs
New class of senotherapeutic drugs that could possibly target various diseases and ageing
Gold-standard trial included 35 participants taking 1000mg of NR (or placebo) for a week
Tailoring strategies to eliminate bad cells in age-related diseases
Senolytics showed positive effects on rats but trials must confirm these findings on human brain
Brief exposure to five factors targeting tissue repair aspects triggers dormant regrowth potential
Fast, cheap and plentiful iPSCs will be needed for clinical trials and new treatments
Could lead to alternative to whole-organ liver transplantation
Boosts mitrochondrial health & muscle activity in aged people and those who don't exercise enough
With age, these fish get bigger and more reproductive capable with only minimal risk of death
How emerging science and lifestyle choices could extend life and transform society
Interactions with mitochondrial & synaptic proteins highlight targets against Tau-mediated disease
Huge backing that cellular reprogramming can have a significant impact on health and ageing
Funding will ensure the development of a new immunotherapy for age-related diseases
Predicting death based on the gap between chronological and retinal age
Government policies have not reversed long-term decline in population growth
Highlights some nuances when investing in the longevity industry
Seeking funds to develop gene therapies that target ageing in humans and dogs
Epigenetic age of individual cells helps tracking ageing process in various tissue types
Invests $82 million in research platforms, aiming to prevent or reverse age-related diseases
Founder convicted of wire fraud and sentenced to several years in prison
This supercentenarian is already aiming to live to 120 years
There is a phenomenal amount of work going on across the spectrum of ageing - something is going to work eventually!
Funds to develop regenerative therapies for retinitis pigmentosa and advanced age-related macular degeneration
Dasatinib plus quercetin slow down muscle regeneration in young mice
Aiming to invest in 15-20 biotech firms, including Cambrian Biopharma, to target drivers of ageing
Dutch authorities warned the use of these necklaces, bracelets and sleep masks
New research claims in removing zombie cells behind aging by vaccination
Brain volume and lifestyle can increase difference between chronological and biological age
Improved survival via eliminating old cells - potential candidate to slowdown ageing
Potential oral treatment to prevent sarcopenia and frailty, and extend healthy lifespan
Aims to extend healthspan and cure ageing with affordable epigenetic therapies
Raised $18 million Series A funding to speed up ageing research
Rejuvenation continues after 4th dose - will be very interesting to see if max lifespan increases
DKG subsidiary to introduce biomarker-driven Longevity risk mitigation and intervention support
Mentorship and funding support for biotech innovators tackling ageing
Reducing nicotine addiction in youth by restricting access to tobacco products
Biotech experts back 1E, believing it can transform medical treatments
Exercise plasma boosts memory and dampens brain inflammation
An injection of extracellular vesicles improve muscle regeneration
Raised $46 million to commercialize and advance robot-assisted surgical technology
Invests in early stage companies that target root causes of age-related diseases
Raised $2.5 million to discover and sell life extension products directly to consumers
Long wavelength exposure partially restores ATP and improves eye function
Morning exposure to long wave deep red light showed 17%-20% improvement in colour vision
Evident reversal of Dementia symptoms sustained cognitive improvement
Dietary composition has a powerful impact on mitochondrial function
For decades, a major challenge for scientists is central nervous system.
A hot topic in longevity research is plasma exchange for Alzheimer’s disease
Cases of anxiety and depression are now doubled when compared to pre-pandemic
Insights on longer-living species could offer the targets for extending lifespan in humans
Telomeres repair can prevent senescence and genome instability
Screening people at risk of genetic diseases thereby reducing the burden of health care costs
A single dose of CRISPR Cas system cleared 99.9% of harmful bacterial in mice
Besides geology, scientists believe multifactorial hormesis contributed to longevity benefits
Lorna Harries believes dysregulated splicing as a breakthrough senotherapeutic target
New study results show clinical applications in pathological ageing
Eric Merle details Genoskin's technology and its applications in anti-ageing trials
Novel business approach helps people to live longer with good health
Merger to improve remote health services and offer personalised treatment plans
Experimental therapy to transfuse healthy mitochondria from multiple donors
Potential gene silencing approach in porphyria and possibly for many other diseases in the future
Increased blood pressure was linked to dementia and older-looking brains
From drug discovery to longevity insights, a startup reshapes age-related medicine
Significant alteration in lineage potential by NR treatment in mice
Leveraging systems pharmacology to streamline drug development and optimize therapeutic outcomes
New insights into the genetic regulation of leukocyte telomere length
Report finds alarming fall in life expectancy even before COVID pandemic - calls for better policies
Noninvasive imaging technology used to observe aging on the cellular level
A unique treatment approach for ageing; will soon begin trials in animals and human cadaver tissue
Chromosome abnormality reported in a clinical trial raises doubts on patient safety
Plans to invest in 10 start-ups - any of which could make a step towards longevity escape velocity
Boosts immune response by clearing senescent cells; a potential treatment for COVID-19 in humans
The atlas of the brain cells developed will help pave the way for future research in brain disorders
The foundation's mission is to make longevity medicine accessible to everyone - fantastic news!
Retrotransposons activate immune response against precancerous cells - may have implications in humans
Many studies underlined beneficial effects of calorie restriction in various tissues of mice
Challenges of mass producing stem cells and how 3 companies are attempting to overcome them
One drug doesn't fit all; combination therapies to address multiple ageing processes at once
Retains structural and functional effects even after preserving at subzero temperatures
Coprata and Toi Labs among companies looking to bring products to market in the next couple of years
Possibility of regeneration: A boon to the broad rejuvenation field
Developing therapies to extend life in dogs, and further extending the research in humans
Life expectancy will recover in the future, but with a 'slower growth'
Funds to bring affordable and effective age-related therapies to the public
A step towards breathing harmless air amidst rising evidence of deadly harm from air pollution
GrimAge finds link between greenery and reversal of DNA methylation & other health benefits
Energy generation in living cells by programmed exosome fusion
Dasatinib and quercetin combo preserves spinal discs to target age-related back pain
Worldwide 28% of countries adopt pronatalist policies to drive up the birthrate
Cryopreservation protects the dead body from decomposition process after death.
NANOG targets multiple ageing mechanisms - insights may help develop new therapies for age-related disorders
$40 million for clinical research, lead program-stroke recovery focuses GDF11
Potential RNA-guiding enzymes that are capable of editing and modifying DNA in human cells
Interestingly, rapamycin (and other drugs) also improves accuracy of protein production
Rare variants in non-coding RNAs are connected to various neurological disorders
Tracks biological age from physical activity without requiring a blood test
Short-term treatment of mesenchymal cells with acetate resulted to enhanced stem cell
Reversal of thymic aging possible through signaling based interventions
A breakthrough technology focusing on effective gene therapies for healthy longevity
Exposure reduction targets aim to lower air pollution levels
Developing painless tests to detect lung cancer, liver diseases, respiratory diseases, and gut health
The “bad” process of pore opening and the “good” process of UPRmt - connection revealed
Reduced inflammation & bone damage in mice; relieves patients from their regular use of injections
Raised $440m to advance e-RNA based medicine for a wide range of diseases
Tracks rate of ageing and predicts onset of disease or death with a single blood test
By investigating self-healing mechanisms in animals, Fauna bio aims to cure human diseases.
Novel genes increase DNA repair and limit damage to slow down ageing process
Products promising weight loss are for sale on internet; users may face health complications
Discusses causes and prevention of NAD depletion with a focus on CD38 consumption
Levels of ubiquitin-tagged proteins affect lifespan - insights may find answers to longevity
Very much looking forward to seeing published results on initial human pilot
A promising approach to restore eyesight in visually impaired people
Keeping your brain active, whether through work or hobbies may delay dementia
Tendons regain their original healthy condition within 2 months of therapy in sheep
Novel gene therapies to prevent the accelerated aging process
Accelerated hair regeneration in the androgenetic alopecia mouse model
Metabolism remained same throughout the mid-life and starts to decline only at 60 years
Stimulated senescent human umbilical vein cells showed high susceptibility to inflammatory diseases
Reliable and safe generation of a novel stem cell-based therapy for dementia
Treating with BMP2 and Csf1 antagonist in mice restored youthfulness to the aged skeletal system
Improvement seen in blood stem cells of mice and humans against stress and ageing
Two novel compounds fuel mitochondria to maintain energy balance and lower UV damage in the skin
ECM reprogramming to identify drugs which can slow-down or prevent age-related diseases
Mitochondrial genome used to potentially treat fatty liver and prevent obesity
Get the measuring tape out, here's another biomarker to track!
Encellin's encapsulation device protects implanted cells, promising targeted cell therapy
Molecular level benefits observed (inflammation, senescence) as well as physical ones
Microbiome in the gut could potentially slow down brain aging and improve cognitive functions
Local centenarians share the secret to longevity: good food, active lifestyle, and sociality
Most approaches have their limitations but good progress is being made on several fronts
Activation of CaMKII improved muscle fitness but increased the risk of ageing
Food firms in UK failed to meet targets for reducing calories, sugar and salt in their products
With an accuracy of 4.7 years it is much more convenient for home testing
Evidence of cryptic transcription in older cells offers new strategies for longevity
NHS suggests to take multiple readings to detect the drop in oxygen levels
Fuels bile acids to prevent infections, but more research is needed to confirm its impact on longevity
Advanced gene therapies can reactivate hair cells, which are vital for hearing
Discusses animal trials, potential human trials, reeducating the FDA and improvements in technology
Supports ageing research and advancing early-stage projects to phase 2 trials over the next decade
Compared to blacks and Asians, whites and mixed groups had lower life expectancy
Myristic acid, benehic acid, and omega 3 increase lifespan; palmitoleic acid lowers lifespan
Lifespan differences exist even between rich and poor siblings/twins
DNA region: VNTR2-1 plays a role in human aging and tumorigenesis
Both companies to continue with the diverse technologies and product development
New action plan to reduce air pollution and improve people's lives
Anti-ageing probability validated from a worm with human-like metabolism
Largest drop since world war II, mainly affecting Black and Hispanic Americans
Large, long living animals offer insights on natural ways of cancer resistance
Freely accessible software from GitHub to help scientists speedup their research process
Chair of American Aging Association disappointed ARPA-H may only receive half the requested funding
As more people live longer (lifespan) it is essential that their health keeps up too (healthspan)
Measuring immune health with a chemokine, CXCL9, for early disease interventions
Nespresso for protein production: prototype inspired from single-serve coffee makers
Senolytics for cartilage and bone regeneration in jaw joints, proven effective in mice
Elamipritide protects your retinal cells from undergoing degeneration
Senolytic drugs administration promotes locomotor and sensory recovery
There may be less men queuing up for this first generation longevity treatment!
Begun phase 2 trial including patients with early stage of disease to test its safety and effectiveness
Covid preventive measures seem to further exacerbate the risk of loneliness
Insights on longevity, neural, and immune adaptations are revealed by a lobster
Latvian based startup aims for cost-effective research studies, prioritizing study participants
Targeting SA-T cells: A promising intervention to control age-related chronic diseases
The $2.2 billion deal will focus on immune-based therapies for neurodegenerative diseases
Twin study allowed impact of lifestyle factors on epigenetic aging to be determined
High death rate in poorer areas, post-covid levelling up must prioritize health equity
Too early to tell whether off-patent drug's effects in fruit flies will be seen in humans
Optimistic on ageing research and a breakthrough human trial to extend healthspan
Connecting aspiring longevity founders with mentors to drive innovation in anti-ageing biotech
Phase 1 trial reports, single dose of the drug cuts protein levels by 87% in ATTR amyloidosis
Long-term safety of the diet is questionable as it alters the healthy gut microbiome
The glycome changes with age - and is measurably affected by lifestyle choices
Rejuvenation process in germline cells may help find new therapies for age-related disorders
In future, we can locate the genes which are linked to the aging process
Synestia system, a point-of-care device to detect any pathogen in less than 30 minutes
Reduced beneficial gut bacteria and increased systemic inflammation in aged mice
Lou Hawthorne, CEO of NaNotics, provides his account of TPE and feeling younger
Potential stem cell treatment for age-related diseases, if succeded in human trials
Health inequalities mainly affected life expectancy of minority groups
Human hair greying dynamics is associated with biobehavioral factors
New collab with Teva Pharmaceuticals to identify drug targets for various diseases
Peripheral nerve repair could benefit 3 million patients every year
Degraded DNA repair in immune cells can cause premature ageing in the whole body
Convergence of genomic technologies and machine learning digitizes liver biology
Slowing down natural ageing process of pituitary glands with stem cells
New study using biomarkers proved the importance of regular exercise again
Printing brains and transplantable organs to save and improve lives
Possible ways of using reprogramming techniques to develop therapies
we'll gain the knowledge to keep astronauts healthy as they journey further into space
Funds to help this digital health company take a leap in offering quality healthcare
Regulation of adult remyelination in mice by TET1-mediated DNA hydroxymethylation
Rapamycin fails to extend lifespan in telomerase-deficient mice, while improving lifespan by 39% in normal mice
Is it time to find ways to make it our average life expectancy?
One treatment does not fit all - diversified gut microbiota needs customizable medicine
Survival abilities of rotifers may help scientists develop better cryo-preservation techniques
Transcriptomic aging clock: providing insight into the changes involved in aging
Need for stem cell intervention for patients diagnosed with T2DM
Potential treatment for mitochondrial diseases & dysfunction, and extends lifespan
Allows patient's own cells to rebuild the nipple and areola - currently under clinical trials
Overexpression of this protein delays frailty and overcomes age-related diseases
Cricket, rugby, tennis and golf players lived longer; footballers, boxers and jockeys had shorter lives
GrimAge clock presented accurate results on biological age than other epigenetic clocks
Investigational therapy on old mice cleared senescent cells up to 70%, extending life by 20%
Breakthrough in longevity research - cellular energetics may stop or even reverse the ageing process
Healthy diet and lifestyle of Tsimane slowed brain atrophy, lowering the risk of Alzheimer's & dementia
A natural limit of 120-150 is a good start before even starting rejuvenation therapies
Optogenetics bring back vision partially with light sensing proteins - new hope for the blind
Planning to grow multi-chambered heart, to advance cardiovascular therapies in the future
Much needed approach to improve immune function during the COVID pandemic
Stem cell therapies, meditation in hyperbaric chamber are few of his extreme health practices
Successful trial results could bring us skin rejuvenation & tendon regeneration products
Low-level LED light improves wound healing and is a promising therapy for skin rejuvenation
Infected ants lounge in the nest, living as long as their colonies' queen
Patient-specific cell therapies under clinical trials for treating lung cancer and melanoma
Lowers age-related defects of blood stem cells & make stem cell transplants more effective
Anti-ageing therapies targeting sirtuins may slow down multiple effects of human ageing
PEARL: Participatory Evaluation of Aging with Rapamycin for Longevity
Yap hadal snailfish made extra genes to repair DNA & stay alive in high-pressure deep-sea waters
Endogena’s photoreceptor regeneration approach offers new treatment paradigm in retinitis pigmentosa
DHE slowed senescence in intervertebral discs of mice; but its use in anti-aging is still questionable
Antioxidant treatment reversed mitochondrial ageing via cardiolipin in mice
Targets precise location of mutated gene rather than tagging on anywhere
Physically active work life and better lifestyle choices linked to long-term survival in men
Boosting a vital protein, Caveolin-1, this new technique offers hope against neurodegenerative diseases
Funding four bold projects to improve health care outcomes for degenerative diseases
Activated immune cells can treat age-related chronic diseases - a potential alternative to senolytics
Kizoo Technology Ventures helps to bring rejuvenation therapies from lab to clinic
Long-living fish gives key insights on evolution history to age slower and live longer
Vibration treatment eliminates senescence of bone cells - may not be applicable to other tissues
Restoring gut microbial health can reverse declining age-related immune fitness
Modernizing life insurance to keep its customers healthy and alive
Launched home test to track biological age; outcomes of unlicensed gene-therapy are yet to report
Senolytic Therapy Network aims to take the senotherapeutics from lab to clinic
"Very promising" results from pilot study, with phase 3 clinical trial planned
You may have to avoid smelling, not just eating, food for CR to be effective
A breakthrough gene therapy restores eyesight in patients with rare eye disease
Correcting gut dysbiosis alters bile acid levels & may help manage hypertension in rats
Raised $90M in series C funding - off to a great start initiating three clinical trials
A 11-year long research in mice revealed 5 potential compounds to increase human longevity
Will be looking to run a human clinical trial in the next few years
Cell therapy repairs brain damage from dementia and stroke in mice, soon to begin human trials
High resolution telomerase model revealed new protein subunits; promises new therapy for aging diseases
Researchers need more data to understand how it impacts the body
Beyond organs, researchers found a way to restore ecosystem and possibly a fauna ark on the moon
Potential future treatment strategy to prevent sarcopenia when supplemented at a young age
UK Biobank study reveals genetic links & potential treatment strategies for age-related diseases
Dietary, exercise, sleep, supplements, and breathing regimen for 8 weeks reduced epigenetic age by 2 years.
For the first time, cultured retinal cells transplanted & survived in the eyes of mice for a year
In vivo conversion of astrocytes could possibly bring brain regeneration therapies in the near future
Understanding the impact of genes, lifestyle, and environment on ageing
Abl1 gene as a potential drug target improved stem cell rejuvenation in aged mice
UK's soft drinks levy encourages both manufacturers and consumers for low sugar alternatives
Allows to silence bad genes without modifying the DNA sequence and it is fully reversible
Targets mitochondrial dysfunction - cosmeceuticals on its way to reverse ageing signs in humans
Disappointingly, no impact was observed on maximum lifespan - still looking for the next bridge
Establishing a massive database on cellular senescence to improve human health
GrimAge predicts increased cellular ageing & mortality risk in people with major depression
The drugs also showed high safety in human tissue and animal studies
Detectible senescence-specific biomarker allows development of new drugs for age-related conditions
Inactivating Siglec-XII could lower the risk of cancer, but more research is still needed
Longer lifespan in old male mice treated with 17‐α‐estradiol, but four other compounds had no effect
Funds to advance gene therapy for age-related macular degeneration & innovative delivery system
Promising tooth development approach for tooth anomalies after successful trials on pigs & dogs
Huge database of wildlife gut microbiota could screen potential therapies within days
Gene modified macrophages may surpass CAR T cells in treating solid tumors
Recurrent or young age miscarriages can up the risk of dying early, but more studies are needed
Calorie restriction prevents age-related changes to the gut microbiome in mice
Stanford University research published in New York Times - age-reversal is no longer fringe science!
Signaling distant sites to alert & activate cancer killing immune cells in advance
New plant-based longevity pill that offers better access to many health benefits
Givinostat induces stem cells to produce muscle making cells - promising therapy for age-related muscle loss
2.5 hours of HIIT in a week reduces mitochondrial respiration, meaning less energy for the body
Substantial mitochondrial respiratory impairment is included with excessive exercise
Advances in longevity pharmacology to revolutionize healthcare with personalized therapies
Reverses immune ageing and can prevent death from coronavirus infection in the elderly
High mortality rate in deprived areas alarms healthcare inequalities
Balance in cell divisions control regenerative capabilities of hair follicle stem cells
Genes play a key role, but healthy diet and exercise can help you look and feel younger
Mitochondrial-based therapy enters IND to tackle IPF and other fibrotic diseases
Funds to bring the experimental drug to trials; symbolizes booming regenerative niche
Giant leap towards developing transformative medicines powered by machine learning
Spin out company from University of Exeter step forward towards precision medicine for age-related diseases
Virus carries gene encoding protein into the brain -possible breakthrough treatment for neurodegenerative diseases
Federal funding for CLSA advances ageing research, promoting health and well-being of older adults
Working on its first two companies at the moment, aiming at global expansion in the coming years
Becomes most expensive drug ever approved for the NHS - but no lifetime costs
Instead of young blood transfusions, why not make your own blood more youthful?
Positive evolution, gene duplications are linked to longevity and anti-cancer traits of cetaceans
Advancing technologies for tissue and organ rejuvenation with seed funding from Kizoo
Favorable results in single person experiment calls for a larger and formal research
Accelerates clinical trial plans for its lead candidate Rlx-01 targeting age-related muscle failure
SMS cells play a significant role in lung repair and regeneration, and other inflammatory diseases
Tiny lipid particles with gene editing machinery selectively targets liver and reduces cholesterol in mice
A potential application in humans for Parkinson's with nerve grafts made from own stem cells
Biomaterials can form superstructures to help regenerate patient derived neuronal cells
NFL protein increases with neurological diseases: a potential biomarker for ageing and longevity
Despite challenges, many companies and clinical trials in longevity field are constantly evolving
Considers whether, and impact if, epigenetic clock is one component of a modular ageing mechanism
Engineered cells produce anti-inflammatory drug that helps reduce stress-related cartilage damage
Spermidine supplemented mice showed anti-ageing effects by preserving telomere length
Hybrid constructs help regrow muscle tissue forming new blood vessels in mice
Microbiome becomes unique starting in the mid-life, correlates with blood metabolites
Cholangiocyte-based therapy repairs bile ducts, offers hope to repair damaged donor livers
Insights on this missing link may offer new interventions for health and longevity in the future
Eos Advisory and Kineticos collab will help find treatment for incurable cancers
Medical Research Future Fund Grants AU $1M to progress vision processing software
More and more companies making greater and greater progress - 2021 could be an exciting year
NAD+ levels, senescence and chronic inflammation collectively influence ageing
Macrophages and stem cell interaction promotes muscle repair in zebrafish and mice models
Less inflammation due to shorter immune memory prolonged life of blind mole rats
With the improvements in awareness and better patient care, death rates and incidence of stroke decreased
New York-based biotech company with unique approaches to treat age-related diseases
Yearly report of their activities including policy papers, senolytic research and an activism prize
Boosting NAD+ levels improves health span and can treat age-related diseases
Two kinds of question that people ask about developments in life sciences and biotechnology:
Poop to pill: fecal transplants restore healthy gut microbes boosting immunity to fight cancer
Life-course BMI analysis revealed association between weight gain and mortality
Biotech startup to make stem-cell based therapies to extend and save lives
Reprogrammed stem cells treated Parkinson's in rats; initiating clinical trials soon
Despite age-related risk factors, super-agers had only a slight decrease in memory
Helminth parasites may provide protection against inflammation disorders
Good to have another cyronics provider in Europe
Korean startup on regenerative therapy creates living tissues, potential of replacing organs too
Tissue engineered muscle under simulated exercise prevented chronic inflammation
Trials on mitochondrial transfusion might help tackle many ageing diseases
New automated system with AI searches genes, drugs to extend human healthy lifespan
Conboys are planning a modified lifespan study - looking for funding
Failed to mimic dietary restriction pathways on extending lifespan in progeroid mice
Reported major drop in women than men; Post-pandemic data could be the worst
Post-demo on rodents, researchers to begin brain-brain communication in humans
Results in mice suggest that it can increase median lifespan in humans by 15 years
Senolytic drug and cancer drug with quercetin improved age-related cognition
This treatment could help in cases of severe liver disease, like NASH
Their work will be critical amidst the COVID-19 pandemic - to move into clinical trials soon
Instead of targeting specific hallmarks/pillars - they want to target ageing as a whole
EP2 receptor which causes inflammation & ageing was knocked down in a disease model
A potential therapeutic target for ageing, but still a long way to human trials
Expert researchers to address antibiotic resistance with the £100m fund by Ineos
Dietary indices found heritable food and nutrient patterns among female twins
Hydrogels in tissue engineering with cell signaling protein combinations
With positive results in mice, scientists expect to slow down ageing in humans
Raises a total of $2M dollars this year amidst the pandemic
Govt unlikely to achieve its target of adding 5 healthy years by 2035 based on current trends
Studies show promise with metformin - tiny positive outcomes with side effects
Let's hope other stem cell treatments are closer than 15 years away
Most hallmarks of aging only described in mice, so far, but Luigi Ferrucci is still optimistic
Tissue stiffness alter immune system response to chronic diseases and ageing
A revolutionary technology research to provide the cure for age-related diseases
Dilution Solution hypothesis better explains the effects of parabiotic experiment & TPE
Telomere length may not be an accurate indicator of lifespan & health in the elderly
Could eliminate the risks of traditional non-degradable permanent prostheses
Unveiled the mechanisms for DNA impairment; laid foundation for future research
Hope to launch a clinical trial in kids soon using this approach
Animal model studies that help in better understanding musculoskeletal ageing
Funding targets early-stage companies and postdoc researchers with unique ideas
Scientists to use this approach & treat deafness due to other mutations also
IMTs degraded 1 in 3 cancer cell lines in vitro, and early promise in mice
Echoes some thoughts from his book "Ageless: The New Science of Getting Older Without Getting Old"
I wouldn’t suggest drinking Coke as part of your longevity diet!
Raised $11M funding which goes into trials and developing functional organs
Insights on this unique strategy could have breakthrough treatments for ageing and many diseases
Shortening telomere length in cancerous cells will prevent them from dividing
Such claims made by trusted companies without a scientific basis mislead the public
Green light activated E.coli genes, extending life in Caenorhabditis elegans
Results aren't published in any journal but might be the first step towards more human studies
Life expectancy to drop by 3 years - greatest cut off since World War II
Many people were disappointed that Katcher didn't report lifespan impact - this is about to change
Biological clocks should make sure they're using 'causes' and not 'effects' of ageing
Super agers with a rare gene mutation counteracts accumulation of aging proteins
Greying of hair is irrespective of age and gender; Scientists work on stem cells
Big gains in c. elegans life expectancy rarely translates to humans, but another avenue to research
Aim to intervene in ageing-related diseases before they cause harm. Sounds like curing ageing!
Authors covered biological age clocks, senescent cells, longevity genes, and more
Deep longevity's psychological clock might help you feel younger and live longer
A study in UK records shocking levels of vitamin D deficiency in certain groups
Comprehensive review of companies' clinical and financial state of play
Tracks your blood glucose in real time - helps optimise diet and exercise
Antioxidant ergothioneine alleviates harmful effects of oxidative stress on telomere length
Senescence killing drug in mice might unveil new heart attack treatments
German Bionic raises $20M fund in Series A to develop its exoskeleton technology
Red light improved health and lifespan of fruit flies; might work on humans too
Will help treat diseases due to immunodeficiency or autoimmunity
Blocking it improved muscle strength & function while endurance was also boosted in mice
Coronavirus slashed the upward trend of life expectancy in England and Wales
High-calibre individuals with expertise in biology, public health, technology, and philosophy
DeepMAge is an accurate ageing clock so far and could be a key in medicine
Will help in kidney tissue engineering and regenerative medicine
Avenna's glyhealth alerts practitioners about subclinical chronic inflammation
Using machine learning, they plan to expand RNA therapy to treat various diseases
Early data from Vertex & CRISPR showed promising results to cure blood disorders
Control neurogenesis by causing nerve stem cells to divide & thus help brain adapt in mice
Not only is there no cure for AD, worse, there could be harmful ingredients in miracle tonics
Lead therapies of BioAge to treat age related diseases enter phase 2 trials
Directing T cells to attack other T cells - a new treatment for autoimmune diseases?
David Sinclair says findings are 'transformative for the care of age-related vision diseases'
Telomere shortening might be a protective measure to ward off cancers as we age
An experimental drug restores age related memory loss and brain function in mice
Proteomics is integral to accurate diagnosis and treatment for personalised medicine
Using Epigenomic Controllers to alter DNA transcription rather than the genes themselves
I've just donated to help #UnlockLongevity - these are the experts and they need funding!
Collaboration leverages cutting-edge DNA-encoded library technology to target unmet medical needs
Will help in developing designer meds, better crops & 'green enzymes' to counter pollution
Molecular simulations have discovered an enzyme with anti ageing and anti tumour effects
Less than 3, or more than 4, results in accelerated ageing after menopause
GrimAge can accurately predict all cause-mortality than any other clock
A 73yr old believes in future technology and signed up for cryopreservation
Keystone Bio's first ever biologic on the planet to eliminate oral pathogen
Therapeutic strategies to combat human skin diseases at single-cell level
Zokinvy blocks production of a defective protein to lengthen the shortened life span
Mitochondrial damage accelerates ageing on exposure to space radiation and microgravity
Senolytics to treat cancers - study finds correlation between senescence & survival
First ever drug guided stem cell therapy in the field of regenerative medicine
rGDF11 in clinic targets multiple age related disease therapies
Scientists discover a pathway to attenuate the deleterious effects of obesity
Platform is designed to help pharmaceutical companies detect substances efficiently
Could be used to develop livers for transplantation and organ on chip testing
Scientists found exciting benefits by inducing a gene mutation in mice
Plan to integrate it with their FDA approved Monarch robotic surgical system
Stimulating growth factor to grow new blood vessels in the heart of mice
Not as easy as taking a pill, but a stunning result on both telomeres and senescent cells
Uses CRISPR technology to target and destroy cancer cells
Reduces neuroinflammation & promotes neurogenesis in aged brains of mice
Elderly have a higher mortality risk with COVID - reversing ageing could reduce it
Senescent cells induce NAD+ decline via activation of CD8 macrophages
Altering gut microbiome might be helpful in preventing or delaying Alzheimer's
Scientists link metformin toxicity with age in young,old non diabetic organisms
Path to a new therapy- replacing blood with youthful factors might reverse ageing
In August, Unity announced that its lead drug candidate had failed to beat a placebo in reducing joint pain and stiffness.
Semi-automating tissue differentiation makes artificial tissues at a faster rate
Decreases chronic inflammation and the risk of cardiovascular disease
Microbiome altering might help in preventing or delaying Parkinson's and Alzheimer's
AVITA Therapeutics and the Houston Methodist Research Institute enter research collaboration
Study in mice and humans found CRELD1 gene's role in immune cell aging
The anti-ageing peptide promotes skin health and reduces senescent cell markers
A study on mice supported ibuprofen for use in neurodegenerative diseases
Restoring NAD homeostasis could help in ageing diseases with telomere dysfunction
Researchers engineer novel protein that restores vision in blind mice via gene therapy
Researchers found a new link in aging from a 15yr old approach
New generation companies develop novel cell therapies using stem cells
Will explain why some brains age faster and make people susceptible to certain diseases
Metformin might inhibit muscle building but makes gene expression more youthful
Called VEXAS- discovered using a novel genome first strategy
Interoperability has always been problematic in healthcare - we really need to crack it for ageing research
A core set of genetic regulators involved in ageing have been found
Topical supplement which extends skin span-the period of time your skin is healthy and youthful
Telomere transfer from APCs boosts T cells lifespan-helpful in immunosenescence
Studying organisms that live long will help identify crucial genes associated with ageing
Key investors raise funding to support longevity sector
Taisho and Insilico collabs to identify novel targets for senolytic drugs
A new approach to treat diabetic macular oedema
Now we can better understand processes that regulate cell survival in ageing
Repurposing the potential existing drugs might eliminate the risk of developing infections
Will make it easier to target treatment to specific locations in the body
Temporarily reactivating dormant genes could allow body to repair and regrow retinal cells
From coffee enemas to pants blocking EMF radiation - his routine is straight out of a sci fi movie
New skin was able to produce fur - might eventually become a treatment for baldness, who knows
IL-12 self-replicating RNA delivered in lipid nanoparticles (LNPs) shows good results in mice
The company with $170 million private funding has invested in various life extension therapies
Mice study also saw improved cognitive abilities
Now we can produce large quantities of human pluripotent stem cells
Lifespan of hair follicle stem cells can be prolonged by changing their metabolic state
Advancement in human augmentation doubts human safety and equality
Not just average length that is important, so full profile provides more clinical uses
A magnetically controlled microrobot connects clusters of nerve cells
Life expectancy at birth has doubled since the mid 19th century
Study compared functional ability between cohorts of same age but 30 years apart
Marks new era in advancing screening and early diagnosis of cancer technology
Japan has the highest life expectancy in the world and homes the oldest person alive
Circulating CRP and albumin (among other molecules) found to be related to frailty
Metabolites vital for pro-longevity effect of calorie restriction can help develop drugs
Helps us to understand the mechanism behind CR - and that it has an effect within weeks
Novel autophagy-based approaches target muscular dystrophy and other challenging diseases
A great summary of the history,biochemistry and life-extending potential of alpha-ketoglutarate
Improved air quality and access to nature would improve everyone's health
Peptides reduce inflammaging and improve standardised physical tests
Will be presenting a viable therapeutic strategy using IGF signaling at ARDD 2020
Blood levels fall with age. NUS planning a clinical trial with middle-aged humans.
Study finds link between ultra processed food and shorter telomeres
Eating habits and exercise alter blood glucose levels - wearables may help get a rough idea
General feeling that failures are bound to happen - but that their approaches can succeed
Takes us a step ahead towards regenerating organs for human diseases
Will lower the cost & speed up the process of developing drugs
A single injection could treat motor diseases of the aged but needs more human studies
Dr. Hinohara gives life advice on how to live longer, happier and healthier
Senolytic research is in its nascent stage but no reason why one shouldn't be hopeful
A great example of compressed morbidity - Fredie was still active 2 weeks before his death
A good example of why you have to be careful buying meds - even big pharma has problems.
App that monitors both digital and biomedical markers, sets for launch in 2021
Successful in mice, new approach may ease immune burden of herpes in humans in the future
Could pave way for preventing the disease in humans and improve healthspan
Declining muscle strength and ageing cognitive function are linked
Disappointing first result - but lessons learnt and plenty of other strategies available
Bioengineered minimally invasive shielded stem cells reduces heart attack damage
Principle tested and a success in mice and humans, to ease arthritis in the future
Insights can tell what you should and shouldn't do to improve your longevity status
Apps such as Young. ai will play a key role in helping understand and reversing aging processes
It would be interesting to see how long they lived with regular treatment through old-age
Study in mice revealed great progress and potential for curing fibrotic diseases in humans
Causation vs correlation to be confirmed - but death affects ALL cells in the body, not just YOUR cells
Its upregulation could be a new prospect for anti-ageing interventions
Balance is key to everything especially with human body
In 60 seconds, can identify ones rate of ageing, BMI, among others
This time, focusing on the narrow population, the centenarians, would give us answers
Discovery of this homeostatic function just may be the first step but it looks promising
Demonstrated in mice, far from human trials, but a potential longevity intervention
One should still consume adequate nutrition while reducing calorie intake
Company has gathered support from investors to quickly lead therapies to clinic then market
Commercialization of tissue and organ regeneration process for clinical use
Decade-long studies of identical twins were able to reveal connections
Experts raise some interesting end-of-life questions - ones which will soon, hopefully, be obsolete
Early days, but looking forward to seeing the results (in vivo) in mammals
Given senolytics are unlikely to ever clear every senescent cell, exercise will still minimise bad effects of those remaining
New gene expression therapy for various targets, with clinical trial planned for 2021
Old cells will be more young and beautiful
Supplementation with this anti-inflammatory drug can give us more benefits than we know
NRG1 treatment boosted activity of gut stem cells - could help protect gut during chemotherapy
Only a small study (17 meditators) but interesting nonetheless
New drug could become the best one to target and treat multiple tumours in the future
It's more effective than any drug so why not prescribe it?
Tested some aspects in rats, could make lab-made organs for human transplant possible
Gains in fruit flies and roundworms give insights to extend human health and lifespan
Betalin's biological scaffold holds beta cells that release insulin instead of having to inject it
It does seem way to early to be settling for any single type of clock for rejuvenation research
It's a long way to go to having an effect in humans in vivo, but an interesting approach
Profit from OS-1 could fund development of more products and clinical trials
We need a single biological age figure as mortality risk applies to the whole body
This includes regulating 'junk food' marketing and consumption
Good news is that almost half the researchers believe age reversal is possible - unimaginable 5 years ago
The site has been selected for long-term survival from natural and human-made disasters
"I would say that the science is now for this field" - I couldn't agree more
Study finds link between ageing and elevated blood iron levels
Analysing mutations in individual cells will help determine its burden on ageing damage
Genes linked to iron metabolism were also responsible for age related diseases
Maybe we need to develop senoplasts like resveratrol as well as senolytics
It may be a new hallmark of ageing, but it's been one of SENS' 7 strategies since it started
Biological clocks are a moving target so they'll need other researchers to corroborate their analysis
It would be great if beauty cream manufactures had to publish objective figures for their products
This organoid with chambers can fit into a mouse's belly
DddA able to target mitochondrial DNA (mtDNA) by splitting in half and hitching a ride
Exosomes will help reduce complications of using living stem cells for brain repair
Another point for the "good" factors argument, though removing "bad" factors likely to be important too
Experiments in mice confirmed this, unraveling ageing mystery if it translates to humans
Derived from bacterial toxin - can make single base pair changes
Targeting immunosenescence could provide benefits throughout the body
Even if it's an effect (not a cause) then REs could act as another biological clock
New class of gene editors set to remove hurdles of traditional gene therapy
It's a different set of skills required to convince government decision makers to change policies
Physical fitness and immune health restored in aged mice models
Manipulation of Eosinophils in belly fat to promote healthy aging
Exercising regularly increases this hormone and benefits muscle and brain
Their extreme biology could be key to preventing cancer in humans
Many tech giants are competing to dominate the mass market for smart glasses
Learning this age-induced disruption of macrophage functions powers pharmaceutical research
If randomised clinical trial replicates results then I might add it to my stack
With genomic database and statistical tools, more interventions can be discovered
Good genes combined with healthy lifestyle choices can truly make you look younger
It could measure biological age and relative health
Benefits were seen, but overall results are not impressive
Could prevent not only the complications but the heart disease per se in the future
Ageing related processes affect different organs at a different pace
Study of environmental factors leading to becoming centenarian opposes previous literature
Longer life results in less offspring - sounds like the ideal compromise to me!
Will it be possible to remove such mutations from reproductive cells?
Gene changes in round worm lead an interesting evidence to longevity
Successful in mice, it may help treat many age-related disease in human
His project researches on secondary senescent cells and SASP
Short-term treatment of this drug demonstrated cytotoxicity among other risks
Models and anti-ageing intervention design enables new ageing clock development
Connections have been elucidated but more research needed to confirm significant links
Study accelerated public awareness on genome sequencing & inspires new treatment approaches
Most people (including me!) won't have enough money to attend, but it's good to see more interest in longevity investments
Tested successfully in mice with liver fibrosis and lung cancer
This could be a cheap first generation rejuvenation treatment - but wait for clinical trials
In both metabolic and physical levels, evidences gear towards positive effects
Lowering the number of bad gut bacteria reduced artery plaques by 40% - wow!
UK-based startup reprogramming stem cells to generate new cell therapies
It's important to keep funding basic research as no one knows where the answers will lie
Didn't change the inherited faulty gene, but gene to switch on fetal haemoglobin production
Supplementation also shown to reverse ovarian ageing
Goal is to develop drugs that target epigenetic mechanisms associated with neurodegeneration
Could lead to new drug discovery against senescent cells and extend lifespan
Confirmed in murine and human cell study, findings can aid development of new treatments
Findings open up new possibilities for personalized regenerative medicine
Proven in mice study to be non-toxic, nor affects brain hunger cues
There are things in blood that drives our ageing
The future new norm to revolutionize how patients get botox and soft tissue fillers
Life extending benefit of dietary restriction might depend upon genetic makeup
Showed impressive results based on experiments in vitro and in vivo, but more work to be done
Major step towards treating baldness, skin diseases, also wounds and scarring
A world-first novel technology to treat the disease is now within reach
Possible as these highly regenerative echinoids show extremes of biological ageing
With phase 2 study announced, hopes are up for end-stage renal disease sufferers
In the future, tech might stop organ shortage, speed up transplant process, and lower cost
If the stress is removed soon after greying has started, reversal is still possible
The clock accurately predicts biological age & can help develop anti ageing drugs
Japan's Pharmaceutical and Medical Devices Agency gives the green light for human trials
Chernajovsky Foundation with BSRA funds for PEPITEM molecule to treat fractures
New study in mice demonstrates an intriguing possibility with senescent cells research
Whoever controls the shape of a molecule controls what it can do
Little evidence of actual beneficial effects (rather than just biomarkers) so not recommended yet
A discovery proven to be of help in therapeutic studies of neurodegeneration
Bob Weighton exhibited many life extending qualities such as keeping interested, socialising and laughing
Its anti-ageing action through skin deep regeneration succesfully achieved
Still one of the most reliable interventions when improving long-term health
Found only in extended-release versions of metformin, immediate-release versions are okay
Using AI to automatically read data from research paper databases and assess users for 20 diseases
A different perspective for preventing age-related bone loss that affects many
When treating a female patient consider how significant sex differences can be
Intriguingly destroys senescent cells without inducing cell destruction
There are lot more to discover and learn about asthma
New concept of 'Centenarian Olympics' allows humans to die young at an old age
I'm not sure survivable cryonics is an easier problem than ageing, but good to have a plan B
Restoring microbiome could be one strategy to support healthy longevity
Potential research area to find treatment options for autoimmune diseases of the gut
This technology is very promising and has an enormous potential
Calico creator is now investing on frontier technology, healthcare & lifescience
Works by inhibiting protein metabolism
With a total of $11 million, more in vivo preclinical drug testing to be expected
Transplanting glial cells in worked in mouse models affected with MS
He believes in the importance of boosting immunoresilience among elderly
Sheds light to potential treatments for age-related cognitive decline, Alzheimer's
Clinical trial in androgenetic alopecia patients show an increase in hair density, thickness
This new approach doubled muscle mass in mice, reduced its fat
These mouse models can be used to study about diseases such as malaria and COVID-19
With the positive results, drug holds great promise for promoting healthy ageing
NAD+ deficiency is for real and it happens in humans too
First study investigating its effects in the normal ageing process
This application of machine learning will soon speed up drug development
Study and procedure represent a milestone in personalized medicine for Parkinson's
Research shows it could be caused by mitochondrial DNA mutations
A report outlines how AI can advance genomics while addressing key challenges
New therapeutic personalized strategy could bring back movement to those suffering
May be it's not just one factor but a combination of all the right factors
Experiments yielded promising results in efficacy, specificity, and non-toxicity
Imagine halving your age with 4 simple injections - at the very least it will buy more time
Feel young, live long, make the most out of our lives with these evidence-based tips
Allowing developments on tech that will kill cancer based on their genetics
Hopes are up for it to directly help the cancer research community and patients
LEAF summarises and exchange of thoughts between leading aging researchers
Detecting blood drainage lags could eventually lead to faster treatment options
VCs are starting to recognise ageing as a problem with a massive business opportunity
Believes life extension treatments may already exist - but need more clinical trials
World-first research reveals how their brain adapts to ageing changes, still perform well
Can aid future trials of therapies aiming at preventing diseases and slowing ageing
Analysing IgG glycosylation: is it the most accurate measure of biological age?
A simple blood test could reveal if you are ageing faster or slower than your peers
Findings can lead future treatments for age-related conditions caused by inflammaging
Able to recover from induced surgical ischameia in hind legs of mice
Maybe it's good, maybe it's bad - still too early to say for sure
Huge potential in a more personalized diagnostics and diet-based disease interventions
Plan de Vida is to live, serve family and community
The deal moves company forward to initiating phase 1 trials in non-Hodgkin lymphoma next year
1,000 free tests available in May - but be quick, my names already on the list!
Made possible by Calico's research expertise and Google AI's machine learning tech
Potential to support new therapies for dyskeratosis congenita, other age-related diseases
Demonstrated in mice, study paves way for treating ageing-related diseases
Tested in aged mice and turns out that it can rejuvenate tissue stem cells
Will be discussing important advances in age reversal - looks interesting (and did I say FREE?!)
Findings in mice study vital for heart cell regeneration and damage repair
Important study in developing cheap and effective treatments for retinopathies
First study to look at DNA methylation changes as mice age and how it affects visual function
Anti-aging research is becoming main stream, because NOBODY is researching how to speed it up!
Early study into complex neurochemical relationship between brain, gut and inflammaging
To support human clinical trial of novel encapsulated cell therapy for hemophilia A
Once again highlights the importance of early life on healthy older ageing
New hope for sufferers of disorders that negatively impact metabolism
Researchers plan clinical trials of this in humans to treat retinal diseases
A new perspective on mitigating the effects of inflammaging, promoting health in older people
We'll almost certainly need a combination of drugs so look forward to seeing the results
Evident in old mice, this exercise can also accelerate muscle tissue repair
With whole exome and genome sequencing we could reveal so many secrets of life
Demonstrated in neonatal mice microbiome mediating an immune response
They found efficient way to increase its senolytic specificity, reduce platelet toxicity
New possibility on restoring injured neural circuitry in humans after stroke
Small study (14 participants) with strict participation requirements, but interesting biomarker results
Stem cell transplantation gives hope to humans affected by stroke
Will senolytics become the panacea to the whole Pandora's box by 100 years into future?
Variety of polyphenols had positive impact on genomic stability
May cause serious adverse effects if stem cells over attack normal lung cells
In animal models, IAP is found to prevent frailty and extend lifespan
As always, it's complicated, but controlling levels of ATM could be part of a therapy to combat ageing
He has kept active through-out his retirement and doesn't look a day over 80!
Entire genome now targetable, open to interventions for use in combating diseases
To benefit long term global health and longevity, and enhance economic recovery
Several short-term responses and alterations are evident in a mice study
Injecting human endothelial cells in to animals caused blood vessels and bone tissue to grow
May be a solution to ageing related mitochondrial dysfunction which leads to diseases
Humans more equal than most species because less of an environmental effect
Stanford University researchers spin out Turn Biotechnologies to develop therapies using OSKMLN
How long will it take until this can be applied to human cells inside the body?
How senescence can fuel cancer development and how malignant cells induce senescence
Healthy gut means healthy body. Thought there are alternative ways of increasing probiotic bacteria!
Scientists created stem cells from supercentenarian for the first time, calling it "super sauce"
We need to recognize normal patterns in order to identify what's abnormal
Still lots to discover, but SENS already looking at ways to stop it in its tracks
Easier to understand in years, rather than percentages. Whole milk a surprisingly big factor.
This arrival of a more efficient stem cell type has high impact for regenerative medicine
A small study, but a big impact on the 7 participants who all recovered quickly
Mechanism behind their exceptional lifespan and prolonged healthspan becoming clear
Safety concerns alerted OpenBiome to recall unused materials and test donors in screening process
Gravity on earth spatially restricts growth of stem cells into actual 3D organs
Strict ethical guidelines to avoid undesirable outcomes in gene-edited babies
These are among other benefits revealing new insights into anti-aging research
Crispr gene editing is a great but a dangerous tool
A success in mice trial, now to move forward to larger animals then human clinical trials
mTOR, a pro-survival pathway for shorter telomeres and inhibition is deleterious
After a successful phase 1 trial of the CVN424 done one mice, the company started phase 2 studies
Government taps doctors, scientists, and UK citizens' personal efforts to achieve this
Including the latest on clinical trials of first-generation senolytics
Evidence of cellular age reversal demonstrated in this gateway research
With this new build, cryonics expected to become more mainstream in the future
I think Victor is right, anti-aging is going to be the next big thing
Will begin clinical trials after completing pre-clinical studies
The club fights for equality in longevity to help everyone access new rejuvenation therapies
As is often the case, it's politicians who need to act before the spotlight is on them
This provides simple, safe way to rejuvenate egg cells as shown in aged mice study
Stimulation the production of stem cells is in direct comparison with the healing speed
HDAC inhibitor shows beneficial effects in mice but too toxic for healthy humans
Potential target for drug-based interventions to delay cellular ageing identified
Foundation of the new therapies mechanism is to access and control the compounds of CSF
Opens new pathways for treatment of disorders such as Alzheimer's disease
Senescent cells seem to play a major role even in heart diseases
Mitochondria-targeted interventions in old mice could be key to age-related diseases.
This life-changing new gene therapy will halt sight loss and improve vision
Werner syndrome, not merely accelerated normal aging as previously thought
We should all be following Sinclair's lifestyle - if anyone knows how to live longer, he does!
It will be more easy and convenient to take samples from skin and saliva, rather than fecal samples
Muscle regeneration would have a huge hit on healthspan - getting people more mobile again
Biomarker caused by glycolysis seen in all types of cancer - exciting possibilities
Yarn helps prevent inflammation which can be caused by synthetic materials used now
By improving the healing process the drug will reduce the life-threatening effects of bone fractures
Needs to study more on NAD+ interventions in order to achieve significant benefits
Senescent cell burden is a marker of disease free years ahead of life
UK residents can buy an AgeCurve sample kit and send a saliva sample
First CRISPR cancer trial in the world publish its promising findings
Protocols were evaluated on the patients with “normal” aging heart
Association with acceleration is strongly expressed in women above the age of 50 years
She's not a doctor or scientist, so listen to the people who are
Cellular senescence is now a top research topic and a very messy one in ageing research
If we can slow down inflammaging we may be able to achieve longevity
It is a comprehensive proteomic database of soluble proteins and exosomal cargo SASP factors
Mitochondria living in the blood definitely has some functions, further research needed to discover
Modulating your stress levels will help you prevent many problems, including your hair colour
Further research will give us a better understanding about stem cells in general
Bridging long nerve gaps from injuries; soon to enter human trials in 2021
Always interesting to hear what Dr Sinclair has to say
Better than just letting the nerves grow haphazardly on their own
When some of these succeed in human trials even more money will pile in to fund further advances
Amutha Boominathan presented her work on MitoSENS project at Ending Age-Related Diseases 2019
Access to healthcare maybe restricted in disadvantaged socioeconomic groups
Knowing which ageotype you are could help focus your efforts on where you're ageing most
Russian cryonics company already has 71 brains and human cadavers
Researchers able to teach old mice new tricks ;)
That's 10 years to find a rejuvenation therapy that adds another 10 years... and then another...
Education and funding are essential to enable radical life extension in the next 20 years
Scientists assume that filaments in the brain played a role in the extraordinary preservation
Preliminary results from Phase 1 trial look promising
Results have been replicated in cultured human cells - a new hope for life extension?
Supercentenarians in Japan - what is the secret behind their longevity?
John Newman, UCSF asst prof & Buck Institute researcher, explains upcoming ageing interventions
An interesting collection of interviews and white-papers with industry leaders
Research of He Jiankui was a violation of medical regulations
Just like rapamycin, berberine also slows down the senescent process
No surprise there is a big overlap in interest in life extension from the cryonics community
Good to see pressure starting to build to handle the coming fundamental changes to society
Are epigenetic changes the cause or a symptom of ageing?
Still there will be many issues even if the spinal cord could be transplanted
If combined they can form the largest database of genetic information on cancer
Solving the mystery of ageing - still at the beginning
Better to read on best practices of calorie restriction with optimal nutrition before you start
Soon it may be possible to print a liver in 90 days instead of waiting for a transplant
Company claims its technology reverses decline of mitochondrial function in aging and disease
Patient-derived induced pluripotent stem cells to replace dead retinal cells
US companies received a warning from the FDA for selling stem cell products without approval
SPF 30+ good quality sunscreen and a vitamin A based product will make you look less aged
New reprogramming technology could provide an alternate source of material needed for therapies
First-in-human trial demonstrates safety and brain-target engagement for TREM2 therapy
Could these proteins be the culprit behind ageing?
mTOR pathway, part of the deregulated nutrient sensing hallmark of aging
The goal to live more than 100 years seems to be slowly drifting away
Gene editing and stem therapy together could bring far superior treatment methods
This topical application of rapamycin did not get absorbed in to bloodstream
New hope for the 37.9 million people worldwide living with HIV/AIDS
Telomeres: are we about to crack the secrets of anti-ageing
Tested in mouse model - but it's a good starting point
Functional organs from stem cells possible through machine learning and gene-editing
Even without life extension experts predict increasingly longer lives
Fossel argues for telomerase therapy over senolytics
Dog Aging Project plans to recruit dogs from all 50 states
Unusually high concentrations of T helper cells found in supercentenarians bloodstream
Avoidable deaths, not medical illnesses, kill more people under 50
Relatively immune to infections and cancers - also get to live more than 110 years
No further clinical trials planned, but some interesting results from initial trial
Most changes reversed when back on Earth - but what about Mars microgravity?
Blood circulation in the brain didn't deteriorate even a bit for 15 months
Long validation times in ageing research – experimental time is a bottleneck
Individuals age at different rates, therefore chronological age cannot say much
Using a fluid matrix instead of a solid support structure may be the solution of bioprinting
Can get into animal cells, so I wonder if this could be used with humans in future?
Interesting articles and some useful investment opportunities
They have a natural mechanism against cellular senescence and ageing
Regrowing damaged organs would help many people live longer, healthier lives
They're often called zombie cells - and turns out they are. Time to kill them with senolytics!
Donating blood could be the most useful thing for now because someone needs it every two seconds
British Heart Foundation working on anti-ageing research? It must be mainstream now!
Gene regulation calmed high neural activity and prolonged life in mice & roundworm
Software guidance for patients gives privileges to white patients over black patients
Their "robot scientist" EVA is set to transform protein-based therapeutics
Indications are less clear with anti-ageing compounds than with disease specific drugs
Except for neurodegenerative diseases, ex-footballers are less likely to die from other diseases
Would we be able to achieve effects of lifestyle changes by just taking a pill?
Phase 1 clinical trial starting early 2020
Is it really the best use of $75M in the crusade against aging?
EVA combines machine learning, robotic automation, and synthetic biology
There are around 75,000 mutations caused by DNA errors and prime editing can correct 89% of them
Will we be able to have a longer lifespan by lengthening our telomeres too?
Is it really possible to develop a drug without side effects?
Many drugs for heart diseases are broad-spectrum senolytics as tested in mice
Presence of free radical damage significantly reduced the lifespan in worm model
Good news – recent quarterly statistics suggest that UK life expectancy is no longer stalled
Systems biology discovers the networks that are essential for a living organism
Bioethicists developed guidelines for dead candidates selection, communication with their families
Analyses a huge amount of data without the help of an artificial intelligence
People who walked slower had a worse state of lungs, teeth and immune system
Doctors from Boston sequenced in detail whole genome of Mila and found the disease-causing mutation
Picking up genes and proteins from other species to make a superhuman
A better option than having injections in to the eye once a month
If the right genes to tackle are identified, this could be the cure for all cancers
There are more serious effects of air pollution on the lungs, but one more reason to find clean air
From lab to clinic in 2 years instead of 10 would have a huge impact on health
Carbiotix and Food Marble partnered to correlate gut microbiome with digestive health data
Will this increase the tendency towards young blood transfusion?
Glucuronic acid levels in the blood can be correlated with a lifespan, healthspan in humans and mice
We need proactive longevity doctors in the UK to advise on best approaches at an individual level
Research suggests senolytic treatments will be beneficial for at least a few decades
In Japan, life expectancy gains have been bigger than in the UK in recent years
LyGenesis is developing a technique for implanting cells into lymph nodes for future transplantation
Detailed history and review of current understanding of Rapamycin and longevity
Does this mean that future therapies to slow down ageing may cause cancers as a side effect?
Includes updates on NAPA Therapeutics and BHB Therapeutics
Tests done on animals suggest that CRMP reduces heart disease risk and animals didn't lose weight
Visible light stimulates the formation of the new blood vessels
Treatment combination consists of lithium, trametinib and rapamycin
People who want to be frozen have to pay AU$300,000 for their entire body, AU$118,000 for the brain
May only be a few years away from implementing induced tissue regeneration in humans
Artificial blood has been effective in experiments on rabbits
UK doctors announce that more than half of the patients can now survive advanced melanoma
Looking good isn't worth dying for - only by creams from trusted retailers
There have been more negative results in mice than positive - surprising given the press it gets
Longevity results can be unproven and not ready in some aspects for being used in clinics
According to the study, shortening in the telomere length have reflected in our brain structure
Great video including rejuvenated mice inside David Sinclair's lab
Could be mass produced and applied as a cream without need for needles
Has cleared protein build up in vivo - has funding to develop clinical candidates
Could help tackle venous thrombosis that becomes a bigger risk with age
Could it be used to increase the crop yield to fight against world hunger?
Life extension technology will be expensive, so it'll create inequalities between poor, rich people
The science is changing all the time, we've still got a lot to learn
Once more confirmed, senolytics reduce senescent cells by that preventing their effect of ageing
Scientists used human dermal fibroblast cells for growing and harvesting exosomes from the skin
Occasional senolytic use may be enough to keep senescent cells at bay
Edwards believes 20–30 years will be added to the average lifespan with none of the ageing diseases
Healthy life expectancy (HALE) in Blaenau Gwent, south Wales, same as Zambia
Many customers left with thousands of dollars debt for the machines that didn't even work
Positive results seen in patients who had a heart attack more than a year before
Great intro to life extension's leading advocate - Aubrey predicts radical change within 5 years
Uncoiling DNA molecules starts the process of reprogramming
It powers foetal development and telomere length, but also cancers
Mice who exercised and ate less also had a decrease in bone quantity due to the cut in calories
He started taking resveratrol in 2003, and now added NMN and some metformin
In 2018 consumers spent $43 billion on anti-ageing products according to Orbis analysis
He's optimistic that human trials will convert the majority of people who are skeptical or unaware
Small, uncontrolled trial, but (potentially) very exciting results
May not notice poorer physical and mental capabilities until it's too late
Gene therapy presents injecting the healthy gene directly in the eye to produce working protein
TAME trial lead by clinician Dr Nir Barzilai will begin in November
Creating totipotent stem cells opens ways for revolutionary findings in regenerative medicine
Adjusting the levels of just two molecules in the blood could lead to significant rejuvenation
Aims to prolong the healthspan as well as the lifespan
CAR-T therapy gives hope for the children for whom the standard therapies don't work
Donors cells were adult skin cells, which have reprogrammed into an embryonic-like state
Yet more evidence that hallmarks of ageing are inter-related, not standalone actions
In human teeth, the clusters had given rise to a crystalline layer within 48 hours
This could be beneficial if things go well, but dangerous otherwise
Sounds like a potential solution that can reverse ageing and restore youth
Still not sure how the artificial intelligence does it though
ADF does not weaken our immune system like other fasting regimens do
Good summary of some major investments in life extension companies
There's a chance for at least one of these novel approaches might work
Biomedical engineering is a combination of regenerative and personalized medicine
New powerful tool is developed for targeting the non-coding areas of DNA
Accuracy of mortality risk prediction is high when using this method
Pluripotent cells are like a black box, but they can open new doors for regenerative medicine
This method is already being used to extend the lifespan in lab animals
Study reveals links between bacterial genes and disease risk, key to future protection
Used brain stem cells of young and old rats for this research
Stigma may be a reason for their reluctance to seek help
Poor record-keeping might be the reason why some countries have more supercentenarians than others
Could turning back the clock on genes make us live much longer?
Potential to cure paraplegia and quadriplegia someday in the future
Plasma proteins to the rescue of good-old memories in Alzheimer's
May be one day we will be able to grow our limbs back
Newly discovered benefit of transcutaneous electrical nerve stimulation
There are at least 13 types of LCA - this trial is aimed at treating LCA 10
Cells are being taken from patients' bone marrow and genetically modified with CRISPR
Removing senescent cells will make us vulnerable to cancer
Prevention of losing nucleotide synthesis ability would result in cells slowly ageing
This will be the solution to post heart attack complications
Retinoic acid could be a key ingredient in elixir of youth
Just one pathway out of many that could improve tissue rejuvenation
If only they’d spent the £114m last year on ageing research instead
It took thirteen years for RNA interference technology to come to this stage
Life forms in other planets - we could start by looking for nematodes
Would we, today, allow the reanimation of someone who might reintroduce the 1918 flu or medieval plague?
Ongoing clinical trials for heart patients with cellular therapy to cure damaged heart muscles
Cultured hair farms can be used to replace lost hair and to test hair growth drugs
A fair summary of who's who in life extension from a journalist who clearly isn't convinced :)
Longer healthspans will inevitably result in longer (and longer, and longer...) lifespans
Interesting - metformin plus exercise did not have an additive effect
Urolithin A could help slow certain aging processes, improve the functioning of mitochondria
Needs to find minoxidil analogues that can restore elastin without side effects
Substance circulating in the veins of juvenile mice delayed death and kept the disease at bay
Novel molecular targets for future ageing intervention studies
Understanding how sleep-disordered breathing affects age could lead to new anti-ageing interventions
Two anti-ageing treatments in phase 3 clinical trials and four in phase 2 clinical trials
Key molecular programs known to promote longevity do not last beyond midlife
And they can be located anywhere in the body
But telomere length is not linked to overall multimorbidity
"Pumping" patch could help repair the damage caused by a heart attack
Two proteins may be responsible for improving brain cell growth
Telomerase gene therapy may be a potential solution for age-related neurodegenerative diseases
Research community is littered with interesting, promising foundations for therapies to treat aging
Using droplets of globose basal cells made able to restore the sense of smell of the mice
Will there be an increased demand for assisted death?
Triggers lysosomes to degrade harmful substances that collect in ageing cells
Transhumanism does not require humans to be a specially chosen consciousness
Promising results in genetically altered mice with Alzheimer’s traits
Creating beating cells and blood vessels that could treat heart attack victims
AI-based methods, to explore mechanisms of ageing and improving health-span
Yamanaka factors may be the solution for reversing age-related diseases
Prevents uncontrolled cell division in cancer cells
Verve Therapeutics treatment targets PCSK9 gene
Discovery could revolutionise treatment for vascular and diabetes-related cardiovascular diseases
Low income workers still die sooner—a lot sooner—than high income people
This revolutionary model could have a major impact on organ donations
Identifying consanguinity could be the key to solve this mystery
Reduces length of telomeres and alters mitochondrial DNA levels in cells
Smell could be another candidate for a biological age marker
Platelets and growth factors initiate a healing response which, over time, rejuvenates the skin
50% improvement in complications of therapy, 19.2% in motor examinations and more
Could it be tweaked to be even more efficient?
Gene silencing rather than gene therapy
Unfortunately the effect disappears after returning to Earth
Vampire bats are extraordinarily long-lived for their size
Restoring hearing and vision would make many people's lives significantly easier
COL17A1 protein promotes wound healing, skin regeneration, and reduces skin ageing
Unlike cancer, you don't have to kill every senescent cell
Scaffold is populated by patient's own blood vessels
Supplement has a real physical health impact too = reduced inflammation
Advancing treatments for age-related diseases and healthy ageing
Plain old peanuts are good for you, not just brazil and walnuts
Cancer targeted first, but could clear out age-related proteins in future
If successful, drug could be available in next few years
Turn.bio testing new in vivo therapy - good results for sarcopenia in mice
Immunosenescence is a known factor in longevity
This would be a stunning result if repeated in humans
Rejuvenating the skin can reverse “inflamm-aging may have profound health effects
Nearly 1,000 clinics selling unregulated treatments in the US
Any small chance of reanimation destroyed
Rejuvenation human trials (cell reprogramming) possible in next 2 years
Automation and longevity therapies may amplify social disparities
Over 1 year down in last 3 years - this is not good news
Drugs will need to work better than the free alternative - calorie restriction
nanoMIPs could improve the specificity of senolytics
Already shown success in mice- could become a vital part of orthopaedic medicine
Live Forever Manual rates IV therapy as "save your money"
Great summary of the drugs history, benefits and risks
Once proven in mice, demand and funding will surge
Reversal of brain cell damage knocked 6 years off disease development
Could lead to off-the-shelf stem cell therapies
Only 2 months after starting. Calling it a medical treatment may be contravened FDA guidance.
BHB therapeutics develops treatment to mimic the effects of good diet
Mental capacity not lost - just masked by inflammation
$16m raided, FoxBio partnership with Juvenescence, lots going on
Will campaign to treat ageing as a disease
Additional benefits include mortgage help and childcare support
Will give insights into how biological and chronological age vary among people
Blood cells have their own agenda for ageing and other cells don't have a say in it
Encouraging signs from big companies - more interviews to follow
Aiming for a market of billions of people, not just the richest
As more people suffer from dementia, men will be affected sooner
Nothing too surprising in his daily supplement regime
Will enable faster analysis of anti-aging treatments
No need to wait till safety trials in humans to detect cardiotoxicity
Useful summary of trials covering orthopedics, nerve repair and vascular grafts
Understanding regeneration in axolotls will be a paradigm shift for medicine
Initial results must be promising to enrol more patients at highest dosage
Able to regenerate ageing immune system, and reduce cost of immunotherapy
Medicine increases healthspan; only life extension technologies will increase maximum lifespan
Successful treatment of retinitis pigmentosa and spinal muscular atrophy
More support for the SENS approach of regular maintenance to stop ageing
It both affects and is affected by its host status
Very early days but good to have more senolytics in the pipeline
Physical improvements recorded, but pulmonary function was unchcanged
Next step is to go to an actual large-scale human trial
The jury is still out whether benefit is from good factors in the young blood, or diluting bad factors in the patient's old blood
A stark example of how birth rate falls below in replacement level in advanced economies
The skin is our largest organ, so reversing its aging would help the whole body
Includes table of fisetin content in range of fruits and vegetables
Always good to find a new biomarker of aging
Intriguing hint that this treatment may have potential for other age-related diseases
Not yet predicting the end of aging, but first generation damage repair therapies.
Developing a virus to express several anti-aging and regenerative factors
We all know exercise is good for us - these biomarkers help to explain why
The way to stay young and healthy at heart
Athletes starving themselves causes hormone and bone problems
Good health should never be the cost of success in sports
Reducing frailty allows people to keep moving and break the negative feedback cycle of aging.
Mr Ratelband, aged 69, made headlines around the world wanting to change his birth date by 20 years
Great opportunity to work with some of the best minds in aging research
Endurance and interval training groups saw telomeres increase by over 3%.
A man in his 50s is the first of seven patients to receive the experimental therapy
Implantation of induced stem cells in brains with Parkinson’s disease is showing promising results in monkeys
Growing new organs from patient's own cells would slash the wait times for organ transplants
Technology allows engineering any kind of tissue implant from one small fatty tissue biopsy
We still need to understand it better but NAD+ is likely to be important in slowing aging
Delivering progesterone to an amputation injury site can induce the regeneration of limbs
Family tree data suggests hereditary genes contributed to no more than 7% of a person's lifespan
Massive study confirms that being overweight dramatically shortens life expectancy
Hematopoietic stem cell therapy allowed a man with multiple sclerosis to walk again for the first time in 10 years
Still a long way to go before expanding life span
Mice fed with fisetin diets lived much longer
Targeting brain function to address Parkinson’s and Alzheimer’s at their core
Innovation is necessary to survive in the field of nanotechnology
Even if signaling is fix, I suspect that there will be some damage already done that needs repairing
If they got past the dangers of childhood, our ancestors lived almost as long as we do today
Fisetin is a very common natural product that has positive effects over health and aging
Direct-to-costumer marketing of stem cell interventions tend to minimize risk and make bold claims without scientific support
Since 2011 living beyond 90 years old has become increasingly rarer due to still unknown reasons
Recent research revealed novel problems with the CRISPR technique, delaying human trials
A case of muscular and cellular rejuvenation thanks to myostatin and telomerase therapies
A company is looking to start trials for induced stem cells to fight graft vs host disease
Killing of senescent (aging) brain cells with an enzyme stopped the progress of dementia
Alternative approaches to tau targets in neurodegenerative disorders
This project aims to observe if the NAD+ precursor has a positive effect over aging mice
Taking an aspirin per day may increase the risk of internal bleeding among the elderly
A topical solution converts cells from wounds into skin to repair tissue without scarring
Findings could enhance the treatments to reverse dementia or destroy cancer cells
All these genes couldn't save them from human hunters
All this to become the longest living beings on Earth and maybe more
β-Hydroxybutyrate and OCT4 slow down vascular aging, preventing disease
Investigating ability of GDF11 to rejuvenate the body
The precursor NMN has some rejuvenating effects over mice's metabolism and gene stability
Researchers plan to implant induced stem cell-sheets on the heart to regenerate injured areas
New research proves telomerase therapy's safety by making its effects within the cell temporary
Patisiran is a new drug capable of silencing genes based on RNA interference technology
Groundbreaking research biotechs performs aging research together for longevity
Life expectancy rises in the UK have stagnated due to still unknown reasons
3 compounds designed to deliver minute amounts of hydrogen to mitochondria inhibit cellular aging
A new study founds patterns of molecules that help predict disease and survival in elderly people
There is a risk of developing brain tumours according to some experts
Harvesting stem cells from teeth may be the key to make treatments more affordable
These small organoids are being used to study Glioblastoma (brain cancer) safely
Advancing immune-based therapies for alzheimer’s and dementia
Newly found lack of precision of CRISPR delays plans for human trials
A French company claims to have a cream capable to reprogram skin cells
Brief description of available robotic surgery procedures and their corresponding equipment
Telomere structure rather than length may be the key to prevent aging
Antoxerene partners with Juvenescence to discover drugs that clear senescent cells
Procedure transplants mitochondria into infant’s muscle cells to prevent heart disease
This therapy uses a modified FOXO4 to promote apoptosis in senescent cells
Senolytic cocktail caused improved physical condition of elderly mice
After 105 mortality rate rise more slowly and it may be related to better genes and lifestyle
These rats seem to be almost immune to cancer for unknown reasons
Skin replication will allow for better quality aging research
The company is going to test a new Senolytic drug in human trials
The gene for CD36 becomes more active in older cells and it may be key for the aging process
Confocal microscopy was used to record stem cells repairing a severe injury in Zebra fish
Study used virus to deliver genetic information that reduced scar tissue in the spinal cord
Skin serums are being used by more women as a way to fight aging
LyGenesis seeks to use a patient’s own lymph nodes as bioreactors to grow functioning ectopic organs
Virus-based treatment seeks to smooth cellular wrinkles in livers
Short-term diets may accelerate the manifestation of aging symptoms
A smaller nucleolus may be a good indicator for aging
Donation came from a private individual involved with cryptocurrencies
This treatment could be used to alleviate neurodegeneration and disease progression
Osteoporosis drug had a dramatic effect on hair follicles in the lab.
FDA seeking court orders to stop two stem cell clinics.
Rejuvenate Bio is cofounded by George Church of Harvard Medical School.
GDF11 is a protein in the blood, which can stimulate cell growth and repair
AstraZeneca will develop cardiovascular and catheter-based therapies.
Autophagy is the process by which cells degrade and recycle their components.
Forever Labs extracts and stores young adults' stem cells.
Melanocytes make melanin which gives our hair its colour.
Look forward to seeing the results of the NAD supplement trial
Their approach addresses enzyme deficiencies, aiming to expand treatments for neurodegeneration
Cibinetide works via activating the body's innate repair receptor (IRR)
Animals produce a antifreeze proteins to prevent cell damaage.
Aortic stiffness was lower in participants with elevated baseline levels.
Wealth enables them to live a healthier life.
Old people tend to have grey hair, wrinkled skin, and weak muscles.
Economists previously concluded that wealth itself increases longevity.
New study shows caloric restriction in lemurs extended lifespan up to 50%.
Coral living in deeper waters have longer lives.
Physical activity data from wearables can produce digital biomarkers of aging.
Currenlty across the world women experience longer life spans than men.
Molecule reactivates faltering blood flow in elderly mice.
Will produce cells derived from iPS cells for commercial applications.
We seem to be ageing more slowly than we were two decades ago.
45 speakers, scientists and entrepreneurs, presented their work.
CALERIE multi-centre trial tested 200 healthy, non-obese adults over 2 years.
Here are some secrets we can learn from the countries where people live the longest.
Major step towards curing age-related macular degeneration.
Josh Mitteldorf curbs his enthusiasm based on latest study.
By the year 2040, people can expect to live 4 years longer in good health.
Nicotinamide adenine dinucleotide is a vital component of cellular function.
All the money in the world to fight ageing and death
Gene therapy could disable genes that sustain levels of lipids in the bloodstream.
Alexander Burik sensibly advises caution about any new type of treatment
Cyclists in their 80s had the immune systems of 20-year-olds.
WuXi interviews Harvard University’s David Sinclair
Bill Faloon inviting people to join a pay-to-participate clinical trial.
Shows how promoters aggressively market unproven yet costly therapies
Office for National Statistics says life expectancy of most deprived males is 73.9 years.
Birth and death dates of more than 86 million people compared.
Previous findings showed that overweight people diagnosed with CVD live longer.
New CRISPR technologies are CAMERA, DETECTR, and SHERLOCK.
Natural chemical in urine appears in higher concentrations as we age.
DNA collected from nearly 2,000 reproductive-age women.
MARCS Institute has demonstrated a groundbreaking noninvasive artificial larynx.
Research pinpoints the cell responsible for improved regenerative abilities in the intestines.
Microengineered Intestine-Chips mirror living tissue.
Celularity is a spinout from Celgene, a global biopharmaceutical company.
Boys born in prosperous neighbourhoods will live 8.4 years longer than those from a poor area.
Report produced by Biogerontology Research Foundation, Deep Knowledge Life Sciences, Aging Analytics Agency, and Longevity.International.
Disabling the SET-26 gene’s function increased lifespan by nearly 20%.
Progressing towards the ability to build complex tissues from a cell sample.
These mouse-sized mammals live way longer than they should.
New method for the mass preparation of hair follicle germs (HFGs).
TERT is a subunit of the enzyme telomerase.
First time ever in the regenerative medicine, children receive new ears grown from their own cells.
New microbiome test kit provides customizable supplement dosing to fill the fibre gap
Possible hints where they are focusing their research
Will rebrand as Enochian and also move to Los Angeles
Will be successful than drugs targeting specific aspects of Alzheimer's
By 2041, women will live to 86.2 years and men 83.4 years.
Interview with Dr. Irina Conboy of Berkeley University.
Duke University has grown the first functioning human skeletal muscle from iPSCs.
Non-coding RNA is never translated into protein.
Inaugural meeting will take place during the World Stem Cell Summit.
Reliable and fast ways to assess biological age are needed to determine the outcome of potential interventions.
Naked mole-rats are near immune to cancer.
A new study released by the US National Centre for Health Statistics (NCHS) found an American baby born in 2016 can expect to live 78.6 years.
3D cell-patterning shapes active mouse and human embryonic cells into thin layers of extracellular matrix fibers.
Study that reveals genes implicated in tissue regeneration, cancer, and aging.
Health researcher claim that Americans are dying younger, and life expectancy is now down for the second straight year — something not seen in more than half a century.
Mitochondria are primarily responsible for generating chemical energy stores.
Senescence is usually thought to be irreversible.
Multiple Sclerosis (MS) patient regains ability to walk with stem cell therapy.
Haemophilia prevents production of a protein needed to stop bleeding.
Mental and physical health levels of a group of Italians between the ages of 90 and 101 have been examined and found that there were many common psychological traits between them.
Injections of blood plasma from young rats improved autophagy and liver function in old rats.
Village peasant microbiome has low risk for atherosclerosis, obesity, diabetes and colitis
Diseases like Alzheimer’s are the result of the loss of proteostasis.
DNA sequences between mitochondria inside a single cell are vastly different.
Decellurised scaffold is basted in patient stem cells, called mesoangioblasts.
R&D phase in SENS repair approach has shown promising results
RNA polymerase III (Pol III) is an enzyme essential for cell growth.
In principle, a gene therapy can do everything a drug can.
60 percent lower risk of death each year if cataracts removed.
The Biogerontology Research Foundation announces the launch of The Longevity Podcast, a podcast produced in partnership with the Oxford University Scientific Society.
Glasgow has topped the list of places with the highest mortality rate in the UK, new data has revealed.
“Virgin birth” stem cells come from unfertilised eggs.
Adults are spending an increasing number of their retirement years in poor health
Mortality rates seen to flatten out in flies and other short-lived species.
3.4 million Swedish people monitor over 12 years.
Amish people have lived in relative isolation since migrating from Europe.
FDA issued new guidelines for expedited review of stem cell and gene therapies.
1,000 people studied extensively from birth to age 38.
Patient lacks a gene that makes an enzyme that breaks down certain carbohydrates.
Human cryogenics is legal in some countries, but you have to be dead first.
Dean Kamen's early inventions include the first wearable infusion pump.
According to the OECD last years report Switzerland tied with Iceland has the longest male life expectancy.
Genetic pathway identified that may regulate the rate at which we age.
Instead of clearing out senescent cells scientists have found a way to rejuvenate them.
Junctional epidermolysis bullosa DNA lacks the instructions to stick epidermis to the dermis.
A team of researchers have discovered 17 new genes linked to longer lifespan, which they say could one day be targeted to help prolong human life.
Some animals are in a state of negligible senescence.
Used a combination of engineering, computer science and biology to analyze molecular processes.
16 people with mild or moderate Alzheimer’s disease received weekly injections of young plasma.
USC researchers have developed a mobile application that will predict how long you’ll live.
Keio University team piled 10 layers of iPS cell culture plates each measuring 20 x 30 cm.
Telomeres are short stretches of DNA are the ends of chromosomes and are essential for fidelity of genetic information during cell division.
Hair follicle undergoes repetitive cyclic regeneration.
A Glasgow University study found people who work in factories and in construction have higher death rates than doctors and teachers.
Proof-of-concept trials starting that pit senolytic drugs against a range of age-related ailments.
Natural stem cell loss in hypothalamus was closely correlated with ageing changes.
Meta study combines genetic, lifestyle and family data from 600,000 people.
Researchers at The Ohio State University in the US examined blood from pregnant women to evaluate the length of telomeres. Shorter telomeres mean an older cellular age.
Mesenchymal stem cells grown and engineered for transplantation with minimal risk.
Accelerated ageing increases all-cause mortality at a molecular level
Around 200 residents of the Swedish city of Malmö will live with host families in Cilento on Italy’s southeastern coast, while the same number of Italians will relocate to Malmö.
Diet and exercise can reduce weight and improve life expectancy
Regenerative abilities to be used in medical applications in the future
Researchers create Expanded Potential Stem Cells (EPSCs) in mice.
Researchers at Lawson Health Research Institute and Tianyi Health Science Institute studied the gut bacteria in a cohort of more than 1,000 Chinese individuals in a variety of age-ranges from 3 to over 100 years-old .
Can predict life expectancy with reasonable accuracy based on diet, exercise, smoking and alcohol habits.
Initial source of age-related inflammation could be gut microbiota.
Heart and liver toxicity is a major reason for drug candidate failures and drug recalls.
A nanotechnology-based solution to bring new hope to millions of blind and visually-impaired
Stem cell research, or regenerative medicine, has great potential and has already delivered some breakthroughs, but its future is threatened by poor science, unrealistic hopes, unclear funding models and unscrupulous private clinics, they say in the Lance
Thymus gland produces the majority of body's T cells.
1 in 5 of the extra deaths in 2014-15 may be attributable being stuck in hospital.
PKD mini-kidneys grown in free-floating conditions formed hollow cysts that were very large.
Can it convert only specific target cells?
Accumulated genetic and epigenetic errors eventually lead to impaired organ function.
Centenarians are the fastest growing age group in the UK, with the number of 100-year-olds almost doubling over a 14-year period.
The gap has narrowed every year for the past decade.
Study in salamanders finds heart tissue regeneration depends on presence of macrophages.
Regenerative medicine is a game-changing area of medicine. It has the potential to fully heal damaged tissues and organs.
Birds are protected from age-related hearing loss. These are able to naturally repair damage to the inner ear.
Annual Meeting agreed to leave minimums 2011 levels.
Some interesting graphs on distribution of deaths by age.
The Women’s Health Initiative collected data from 16,000 post-menopausal women.
Anti-glucosepane antibodies may offer new therapies for age-related diseases
Joseph Vacanti one of the authors of “The Vacanti Mouse” - a mouse with a human ear on its back reveals details about that story two decades later.
Epigenetic drift occurs more rapidly in monkeys than in humans.
Interesting interview with Prof Brian Kennedy appointed to lead ongoing efforts at the National University of Singapore.
Non-profit Betterhumans known for its work in the transhumanist community announced its intention to begin small-scale trials of senolytic therapies.
Nanokicking used to grow 3D samples of mineralised bone for the first time.
Recent research has shown that high-intensity interval training (HIIT) may actually reduce and reverse longterm damage done to mitochondria—the powerhouse of the cell.
Sir Michael Marmot the author of a report on health inequality claims that UK risked becoming the “sick man and woman of Europe”.
Book considers the multidisciplinary aspects of longevity promotion
Study used human heart tissue samples from organ donors and heart transplants patients.
As people age, their mitochondria often become damaged - damaging the cells where any build-up occurs.
New platform will help to identify additional drugs that target ageing processes more quickly
The nucleolus is a major structure in a cell's nucleus responsilbe for ribosome biogenesis.
The F.D.A. reported actions against two large stem cell clinics and a biotech company calling them “unscrupulous actors” in regenerative medicine.
Major new study argues that longer telomeres increase risk of cancer five-fold.
Study into role of microbiota (bacteria inside and on body) on health span of animals.
The number and therapeutic quality of our stem cells diminishes with age.
Researchers commonly determine the presence of senescent cells through the use of the p16ink4a (p16) and ?-galactosidase biomarkers.
Possible to breed pigs to harvest their organs to meet the demand for new tissue
Klotho injections improved memory and motor skills of mice
Can be classified into three groups
Moisturisers do help by supplying water to the skin and trapping it there.
Based on an epigenetic clock origianlly developed by Steve Horvath in 2013.
Cells from children with progeria studied.
NBIC technologies: Rise to possibilities for the domain of science fiction
Implanted stem cells that make fresh neurons in the brain.
We are at an inflection point for the treatment of aging.
With aging the immune response becomes deregulated and inflammation becomes excessive.
People who never smoked cigarettes, were not obese and drank alcohol in moderation had life expectancy of 87 years instead of 80.
Tube worm Escarpia laminata live between 1000 and 3300 metres below sea level.
Life expectancy has been rising for decades, but has recently slowed.
Sarcopenia is a significant contribution to the frailty of later aging.
Considers biophysical qualities of cells, such as cell movements and structural features.
Greenland sharks are the longest living vertebrate on the planet.
Paper in last year's Nature human body and brain petered out around 115.
Villages and islands where people live into their 90s more often than average.
Sinclair Lab studies the processes that drive aging and age-related diseases.
Growth hormone receptors is linked to an increase in life span of about 10 years among men.
Review of current thinking from the Massachusetts General Hospital - the largest teaching hospital of Harvard Medical School.
SkinTE regenerated full-thickness, organized skin and hair follicles in third degree burn wounds.
Cells become dysfunctional or die with aging.
Interesting interview with Peter Diamandis - founder of the X Prize Foundation and Singularity University. Many billionaires are getting annual placenta stem cell transfusions - and feel better for it. Placental mesenchymal stem cells (MSCs) do not t
Update on Ambrosia trial that gives blood plasma from under 25s to older people.
Methylene blue improved physical, biochemical and genetic aging markers.
University of Dundee demonstrate AdPROM to target and destroy specific proteins within cells.
Patient had no cartilage in wrist so joint was bone-on-bone and constantly inflamed.
A guide for anyone considering self-experimentation.
One team reprogrammed skin cell derived iPS cells with seven transcription factors.
The new site for the cells showed promising results for treating type 1 diabetes
Researchers used local clearance of senescent cells (in mice) to reduce the development of post-traumatic osteoarthritis and encourage tissue regeneration.
University of Sheffield has made progress in repairing the damage done to mitochondrial DNA (mtDNA).
The insulin receptor acts like a brake on life expectancy.
Long-lived for its size and rarely gets cancer.
Most age related diseases are a symptom of cellular malfunction.
Researchers inject mice with blood plasma from humans of different ages – babies, 22 and 66 years old.
T-cells mature within this gland.
Middle-aged fish receiving a transplant of gut bacteria from young fish had in increased mean lifespan of 41%.
Novartis sought to see whether giving low doses of everolimus to people over 65 increased their response to flu vaccines.
Study directly targets one of the mechanisms that senescent cells use to avoid apoptosis,
Protein boosts blood stem cells, making them behave like those of younger people.
Synthetic embryos could be assembled from stem cells that can organize themselves into embryolike structures.
Once you reach the age of 60, men and women live longer if they have at least one child.
Study describes a new way that senescent cells communicate via the expression of integrin membrane proteins.
People with sickle cell disease make abnormal versions of haemoglobin – distorting red blood cells into a sickle-shape that can get stuck in blood vessels.
Of the 10 tallest people ever recorded, the oldest died at 56.
Effects of Siberian fir terpenoids on senescent and human cancer cell lines studied at the genetic level.
Induced pluripotency appears to produce a form of cellular rejuvenation.
Adult stem cells collected directly from human fat are more stable than other cells.
Ichor Therapeutics is a biotechnology company focused on developing drugs for age-related diseases.
York University has created in vitro 3D heart tissue made from three different types of cardiac cells.
Strehler-Mildvan (SM) correlation was reported in 1960.
iPSCs treatments have been slowed by concerns that these cells are prone to increased numbers of genetic mutations.
Fascinating data visualisation of life expectancy for 200 countries over 200 years.
Mix of proteins in your blood is characteristic of your age.
Interview with Drs. Michael and Irina Conboy of the Department of Bioengineering at UC Berkeley.
Attempts have been made to rejuvenate the body by transfusing old people with young blood.
Trial in macaques has found that CR makes them live 3 years longer than normal – equivalent to 9 years in people.
Newly discovered a protein, named TZAP, binds the ends of chromosomes.
Growing older results in a build-up of the body’s senescent cells and naturally accumulate with age.
End-stage retinal degeneration (e.g. age-related macular degeneration, retinitis pigmentosais) is the most common cause of irreversible vision loss and blindness in older adults.
Qatar Genome Programme (QGP) focuses on mapping the population as well as treating common and rare diseases.
Ray talks about the singularity, AI and human hybrid thinking with neocortex connected to the cloud.
Peter de Keizer of the Erasmus University Medical Center discusses strategy of removing senescent cells.
It is focused on the twofold path of
Scientists from Penn State have uncovered the cellular mechanisms that control the programming of the stem cells.
Previous attempts resulted in younger cells but the mice developed tumours.
Scientists have discovered that it is possible to stop the activation of a group of proteins – NADPH Oxidase.
Therapies that deliver fresh new stem cell populations will take up the work of lost cells, e.g. muscle cells in order to reduce frailty.
CellAge is going to develop synthetic promoters which are specific to senescent cells, as promoters that are currently being used to track senescent cells are simply not good enough to be used in therapies.
Researchers wanted to find out the impact of RNA splicing on the ageing process
Each treatment will target a different type of molecular damage in cells and tissues.
So as for now it's still not possible to revive those who are cryopreserved
Male healthspan varies from 54 years in Tower Hamlets, London, to 71.8 years in Rutland, East Midlands.
Mammalian lifespan differs by >100-fold
Participants will have their blood passed through a machine that resets abnormal levels of proteins seen in older blood.
Average age of American mothers has increased from 24.9 years in 2000 to 26.3 years in 2014.
Hundreds to thousands of mitochondria per cell each carrying its own mtDNA.
Costs around £28,000 for whole body cryonic suspension
Research published in Nature Medicine finds the compound spermidine improves cardiovascular health.
People in more contented U.S. counties lived an extra two years or more.
Aubrey de Grey speaking at technological Inman Connect conference.
Glutathione helps resist the toxic stresses of everyday life – levels decline with age.
Unity Biotechnology’s technology jump starts senescent cells into dividing again.
Natural compound, called NMN, found in avocado, broccoli, cucumber, cabbage and edamame has remarkable anti-ageing effects in mice.
CRISPR used to correct mutated hematopoietic stem cells.
Swapping an older mouse’s ovaries for young ones reversed the effects of ageing on the immune system and metabolism.
Book review: Cracking the Aging Code by Josh Mitteldorf, Dorion Sagan
World Health Organization quote research that people who hold negative views about their own ageing do not recover as well from disability and live on average 7.5 years less than people with positive attitudes.
Number of people aged 100, or over, has quadrupled over the last two decades.
Study led UCLA analyzed over 13,000 blood samples.
Keio University running a human trial orally administered nicotinamide mononucleotide (NMN).
Desperate patients are ready to do everything to access to new treatments.
Relaunches as a clinical-stage company, with phase 1 clinical trials of lead compound for Alzheimer’s
Telomeric DNA decreases with age and when they get too short cells self-destruct or become senescent.
Raising short-lived species on a low dosage of heavy water appears to modestly slow aging.
1 in 4 want to live more than 100 years – about the same chance as someone born in the 1990s.
Anti-rejection drug rapamycin extend the life of mice by more than 25 per cent.
Reading patterns of 3635 patients aged 50 and older studied.
Ambrosia (https://www.ambrosiaplasma.com/) young plasma trial is open to anyone 35 and older.
New Aether bioprinter aiming to be fraction of cost of existing biological 3D printers.
Could be superior to old school reconstructive procedures
Difference in life expectancy for a 65-year-old:
75 potential targets for gene therapy in the near future.
Talk by London Futurists chair David Wood discussing:
Epidemiological studies have demonstrated shorter leukocyte telomere length (LTL) in patients suffering coronary artery disease, heart attack or stroke.
Sea urchins can quickly regrow damaged spines and feet.
Due out in June – looking forward to reading this well researched book.
Today median age ranges from 18.5 years in Cameroon to 46.5 years in Japan.
Gerontologist Robert Young talks about maximum human lifespan.
Identical twins are less likely to die young from unexpected causes.
EPFL researchers restore ability of mice organs to regenerate – also extending life.
First time gap has increased for 150 years.
DNA mutations that protect the body from UV radiation can also lead to red hair.
Gladstone Institutes has used chemicals to transform human skin cells into heart cells.
Visceral fat is the fat around the organs, rather than under the skin (subcutaneous fat).
New filling stimulates stem cells to encourage the growth of dentin — the bony material that makes up the majority of the tooth.
Greater longevity for those who reduce their calorie intake.
Able to regenerate any tissue damaged by injury, disease, or aging.
Took cells from gums and converted them into induced pluripotent stem cells (iPSCs).
University of Edinburgh researchers analysed genetic information from more than 152,000 people in UK Biobank study.
Life expectancy of college-educated white men 11.9 years longer than their low-educated counterparts.
Sample chapter from Maria Konovalenko’s Longevity Cookbook.
Shorter telomeres discovered in impatient subjects.
Eye-opening results for homeopathy clients - ineffective as a treatment method
Reproduce signalling between cell layers within arterial walls (endothelium and media).
Sections of bone, muscle and cartilage all functioned normally when implanted into animals
Iceland is one of the top-ranked countries for life expectancy.
Closely mimics the human liver’s sophisticated structure and function.
Latest figures released by Public Health England.
Longevity gap between high-income and low-income Americans has been widening sharply.
Increased saliva from gum protects teeth, cutting dental visits and saving money
Naked mole rats can live up to 30 years, making them the longest living rodents.
21st Century Medicine team has won the Small Mammal Brain Preservation Prize and get about £18,000.
Paolo Macchiarini is again facing an investigation into his research practices.
Probably only 1 of many aging factors at cellular level – but every little helps as reducing aging a little buys a few more years for science to reduce it even more.
Cells accumulate damage in their DNA.
Fascinating video of analysis of differences in lifespan of identical organisms.
Direct reprogramming signals a cell to morph straight into another cell type.
Human cells taken from a real liver used to construct a microfluidics-based tissue.
Could replace or enhance drug- and cell-based regenerative treatments.
Pheidole dentata don’t show any signs of aging.
Therapies available in clinics vary in type and quality of cells used.
Dr Elizabeth Blackburn won the Nobel Prize in 2009 for research on telomeres and the genetics of ageing.
Interview with Didier Coeurnelle – cochair of Heales, board of International Longevity Alliance (ILA) and lifelong member of Longecity.
What if we could send the body an instruction to produce its own drug?
Average lifespans may be rising maximum years are unchanged.
Searching the genomes of centenarians these genes are most clearly associated with lifespan.
Tiny hydra – a centimetre-long polyp that inhabits fresh water all over the world – does not show any sign of deteriorating with age.
Brian Hanley discusses the safety of metformin aging clinical trial.
Pandorum Technologies has developed an artificial tissue that performs the functions of the human liver.
Lower levels of antibodies in saliva are associated with of an elevated risk of mortality.
The New Organ Liver Prize will award $1,000,000 to the first team that creates a regenerative or bioengineered solution that keeps a large animal alive for 90 days without native liver function.
Higher than expected death rates among older people in 2012 and 2013.
Could significantly increase life expectancy and health span.
Article says based on “latest research” – I’ve not checked it but, hey, it’s a Friday story!
Great video introduction to one of the causes of aging – telemere length v cancer inducing telemerase.
Risk of dying increases by around nine per cent for every extra 10 beats per minute
Cryonics – the practice of preserving people then reanimating them at some future date.
Cells grown from mucosa then applied to 3D collagen scaffold.
Study highlights association, not causation.
Shortened telomeres have been implicated in aging and disease.
Researchers from Carnegie Mellon University develop new method to print soft materials – such as collagens, alginates and fibrins.
There are definitely environmental factors that influence longevity as well as genetic ones.
Mice received bone marrow transplants from young donors every 3 months from age 6 months.
Able to print extremely delicate iPS cells in three dimensions without damaging their biological functions.
238 genes identified that, when silenced, increase the lifespan of yeast cells.
University of Utrecht finds that cycling 74 minutes per week increases life expectancy by 6 months.
Harvard Medical School use CRISPR/Cas9 gene-editing technology to inactivate 62 porcine endogenous retroviruses (PERVs) in pig embryos. Ten times more edits than in any other animal.
Rohit Talwar of Fast Future will be addressing nearly 300 headteachers at the Headmasters’ and Headmistresses’ Conference.
Turritopsis nutricula jellyfish studied.
If the greatest driver of disease in old age is old age itself, then why not find a cure for ageing.
Researchers gave the mice a compound called nicotinamide adenine dinucleotide or NAD for a week and found that the age indicators in two-year-old mice were restored to that of six-month-old mice. That would be like turning a 60-year-old human into a 20-ye
QMUL create materials using peptides and proteins that self-assemble to form a dynamic tissue.
Jikei University School of Medicine in Tokyo grew kidneys, drainage tube and bladder from pig and rat stem cells.
Regrowth of nerves after injury or disease is very rare.
Cells eventually stop dividing to replace damaged neighbours and to into senescence.
Meta-study carried out by Harvard Business School and Stanford University analyzed 228 different studies.
As well as diseases such as multiple sclerosis everyone suffers demyelination as part of aging.
Biological age determined from signature of 150 genes’ behaviour.
10 micron accuracy bioprinting platform that can be fitted with different types of extruder heads.
Monthly intravenous stem cells transplantations extend life span of rats by 31.3%.
Average life expectancy around the world has increased from 65 years in 1990 to 71.5 years in 2013. So for every 4 years lived your life expectancy increases by 1 year – when those figures are the same everyone is living forever!
Regeneration of the thymus is one of a number of possible ways to introduce much larger numbers of fresh new immune cells into an old body,
Hormesis, where moderate stress has a stimulating effect on an organism and enables the prolongation of life, was first discovered in 1888. This study with weak doses of gamma radiation prolonged the life of fruit flies by 5%.
Dietary supplement alpha lipoic acid (ALA) can stimulate telomerase, the enzyme that lengthens telomeres, which could have positive effects on chronic diseases such as atherosclerosis and diabetes. ALA is present in many foods and counteracts high-fat-die
People in the richest 10% of UK live 4.4 years longer compared to those in the poorest 10% areas. Results in 2010 reduced significantly from 2003 study when gap was 6.9 years.
Worm signals to itself to turn off cell tissues protective mechanisms, precisely at the onset of reproductive maturity, starting the decline of the adult animal. Happens over course of hours. Genetic switch is target for future research.
The manufacturer of the 3Dison range of desktop 3D printers has announced a $3 million government grant with the aim of having a 3D bioprinter working on-site at the Seoul National University Bundang Hospital within 3 years. Initial focus will be bioprint
Spheroid Reservoir Bioartificial Liver (SRBAL) successfully tested in pigs. Healthy hepatocytes reduce severity of liver disease. Over 30,000 people die from liver failure each year in the US alone.
Deleting PTEN gene in mice neurons stimulated growth of axons across damaged nerve up to 1 year after the original injury.
Targeted delivery of functioning TMC1 gene to hair cells in cochlea using engineered virus AAV1.
Existing diabetes drug has been show to delay aging so researchers are now applying to the US Food and Drug Administration (FDA) to run a human trial (Targeting Aging with Metformin, or TAME). Would set precedent for anti-ageing drug.
Study of city of 530,000 trees in Toronto compared to 30,000 residents health records.
Once infectious diseases conquered, deaths from cancer and cardiovascular disease (which affect men more than women) amplify life expectancy difference in 50 to 70 year olds.
NHS to test laboratory made blood – guaranteed infection free. Initial safety trials could lead to mass production of red blood cells for emergency transfusions.
Large pieces of cartilage created. Aim is to repair damaged human joint tissue.
Underweight elderly people have double the mortality rate of others.
Functioning rat forelimb grown using decellularization / recellularization (decel/recel) technique.
Gains in US life expectancy mostly benefiting those with higher income.
Addition of glycine for 10 days to 97 year old fibroblast cell line helped to restore respiratory function.
Scientists at the University of Birmingham who have identified the role of the enzyme 11beta-HSD1 in the degenerative effects of aging.
In mice – but no reason to assume the same isn’t true in humans. Fractured bones healed faster and more effectively in old mice paired with younger mice.
Goal is to create mechanisms to be ahead of vulnerability to illness, or even of death.
Hydrogen replaced with deuterium strengthens bonds between molecules in cell membranes – could reduce free radical damage. Initial trials to try to slow the progression of Friedreich’s ataxia.
PEF treatment resulted in formation of microvasculature, secretion of new collagen and increased metabolic activity in treated skin. New epidermis proliferation can improve skin barrier function against infection and hazardous materials.
Danish study of 65,000 people shows telomere length robustly predicts longevity.
Turritopsis dohrnii grows to adulthood in a matter of weeks but can transform back into a polyp using transdifferentiation.
Accumulated alterations in the structure of heterochromatin may be a major underlying cause of cellular aging.
Closing the gap on women. By 2030 men will be living 85.7 years on average compare to 79.5 in 2012.
“vascular prostheses” were completely replaced by biological blood vessels within six months of being implanted. Additionally, no aneurysms, thromboses or inflammation were noted. The technology is still under development, with human trials expected to be
Geriatrics professor Devora Lieberman puts it down to awareness of preventive medicine and proper nutrition – eating food rich in fibers and low on sodium and fat.
Could a financial incentive help people push the boundaries of lifespan?
Russian man to become first to undergo pioneering and controversial surgery.
Salk scientists discover a single protein that energizes both muscles and the brain.
First company to treat a person with gene therapy to reverse biological aging.
Simply captures a photo to reveal biological age - no blood tests needed
Calico is a Google-founded R&D company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan
Senolytics, a new class of drugs, might dramatically slow the aging process and so change the face of old age.
Tony Wyss-Coray from Stanford University presents the results of tests in mice with video footage of old mice performing better in a standard maze test after receiving blood from younger mice. Benefits possibly come mainly from plasma.
New Organ, a collective initiative for biomedical engineering and regenerative medicine, announced today that two new teams have joined the field competing for the New Organ Liver Prize, a global competition sponsored by the Methuselah Foundation, a biome
A water-loving animal called the hydra seems to live forever.
To examine causes of death for men above 80 years of age, and health status in centenarians in a cohort of men followed from age 50 years. Factors of importance for survival were studied.
Researchers delivered a modified RNA that encodes a telomere-extending protein to cultured human cells. Cell proliferation capacity was dramatically increased, yielding large numbers of cells for study.
CR changes near everything in the operation of metabolism and slows near every measure of aging making it difficult to figure out chains of cause and effect.
The number of centenarians in the UK has more than quadrupled in the past 30 years, according to new figures.
The study was published in the Genes and Development journal.
A gene that can slow the aging process throughout the entire body when activated remotely was identified by UCLA scientists.
Cellular reprogramming for readily available artificial transplantable organs
It's not logical to advise people without diabetes to take metformin
He loved the idea so much he bought the company!
But there may be more older clams still living on the ocean floor
Insurance makes it accessible to more people, though critics remain skeptical
The herbal extract of a yellow-flowered mountain plant long used for stress relief was found to increase the lifespan of fruit fly populations by an average of 24 percent.
Researchers have developed an new method for inserting genes into retina cells.
Embryonic stem cells (or ESCs) and induced pluripotent stem cells (iPSCs) are prized because they can replicate themselves indefinitely in a dish or differentiate into every cell type in the body.
Elderly mice suffering from age-related heart disease saw a significant improvement in cardiac function after being treated with the FDA-approved drug rapamycin for just three months.
Transfusing youthful blood factors into an older patient could be a reality soon
Could SIRT3 promotion in humans help with age-related oxidative stress?
His discovery fast tracked the field of regenerative medicine by many miles
A truck driver's face shows devastating effects of 28 years of sun exposure
After age 110 mortality rates level off corresponding to an annual probability of death of 50%
Scientists say they have clinical proof that a face cream available on the high street does reduce wrinkles.