Key points from article :
Diabetes drug metformin, sometimes taken to slow ageing, may blunt the health benefits of exercise.
Metformin currently is the most-prescribed medication globally for people with Type 2 diabetes.
Worms, rodents given metformin typically live longer.
Study included 53 men and women in their early 60s, who had risk factors for Type 2 diabetes.
Participants exercised and took metformin.
Volunteers taking a placebo, had mitochondrial respiration rose by about 25%, unlike the metformin group.
Metformin had blocked the normal exercise-related gains in muscle-cell mitochondrial respiration.
More research is needed to understand how metformin affects mitochondria, exercise and ageing.
The study was published in Aging Cell.
