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It's time for considering drug-exercise interactions

19-Jun-2019

Key points from article :

Diabetes drug metformin, sometimes taken to slow ageing, may blunt the health benefits of exercise.

Metformin currently is the most-prescribed medication globally for people with Type 2 diabetes.

Worms, rodents given metformin typically live longer.

Study included 53 men and women in their early 60s, who had risk factors for Type 2 diabetes.

Participants exercised and took metformin.

Volunteers taking a placebo, had mitochondrial respiration rose by about 25%, unlike the metformin group.

Metformin had blocked the normal exercise-related gains in muscle-cell mitochondrial respiration.

More research is needed to understand how metformin affects mitochondria, exercise and ageing.

The study was published in Aging Cell.

Interesting - metformin plus exercise did not have an additive effect

Mentioned in this article:

Tap on icon for description, click on resource name for more details.

Journal

Scientific Journal devoted to age related diseases.

Academic

Researcher in the Aging and Metabolism Research Program at OMRF.

Institute

Biomedical research institute developing effective treatments for different human diseases.

Academia

Public Research university.