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It's time for considering drug-exercise interactions


Key points from article :

Diabetes drug metformin, sometimes taken to slow ageing, may blunt the health benefits of exercise.

Metformin currently is the most-prescribed medication globally for people with Type 2 diabetes.

Worms, rodents given metformin typically live longer.

Study included 53 men and women in their early 60s, who had risk factors for Type 2 diabetes.

Participants exercised and took metformin.

Volunteers taking a placebo, had mitochondrial respiration rose by about 25%, unlike the metformin group.

Metformin had blocked the normal exercise-related gains in muscle-cell mitochondrial respiration.

More research is needed to understand how metformin affects mitochondria, exercise and ageing.

The study was published in Aging Cell.

Interesting - metformin plus exercise did not have an additive effect

Mentioned in this article:

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Scientific Journal devoted to age related diseases.


Researcher in the Aging and Metabolism Research Program at OMRF.


Biomedical research institute developing effective treatments for different human diseases.


Public Research university.