Key points from article :
Scientists uncover cellular mechanism that regulates ageing and fertility by preserving the architecture of the nucleus and upholding nuclear quality control.
By maintaining nuclear homeostasis, this molecular mechanism contributes critically to promote longevity and fertility.
Recycling of nuclear and nucleolar components via autophagy delays ageing of somatic cells, and sustains the immortality of germ cells, required for reproduction.
They used two experimental organisms, the nematode Caenorhabditis elegans and the mouse.
“We have always been intrigued by the dichotomy between two diametrically opposed, ... highlighting the complex crosstalk of the molecular mechanisms that influence ageing”, Prof. Nektarios Tavernarakis, lead researcher said.
Research at the Institute of Molecular Biology and Biotechnology (IMBB) of the Foundation for Research and Technology-Hellas (FORTH), published in Nature Aging.