Key points from article :
The accumulation of damaged/senescent cells in the body with time is a hall mark of aging.
Prior removal of senescent cells will likely enhance the effectiveness of stem cell transplantation therapies.
SenoStem project will test whether this creates a more favorable niche for stem cells to engraft.
Overall aim is to determine whether these two different lifespan-extending interventions can act synergistically.
First phase will be to carryout in vitro and in vivo studies in order to identify the most effective and safe senolytic.
Second phase will assess the effectiveness of lead senolytic followed by transplantation of stem cells.
Expectation is that the combination therapy will be more effective than either the senolytic or stem cell treatment alone.
