Key points from article :
Team identified a small mitochondrial uncoupler, BAM15, that decreases mice body fat mass.
And it is not affecting food intake, muscle mass, or increasing body temperature.
It also decreases insulin resistance and has beneficial effects on oxidative stress, inflammation.
This is for treatment and prevention of obesity, diabetes, and nonalcoholic steatohepatitis (NASH).
Obesity affects more than 40% adults in US and 13% of the global population.
After series of mice studies, found that BAM15 is non-toxic even at high doses.
To find same type of molecule that can stay in the body for long to fix short half-life downside.
Ultimate goal is to transition anti-fat treatment from animal models to NASH treatment for humans.
Looking to use mitochondrial uncouplers to fight neurodegeneration and ageing as well.
Researchers from Virginia Tech, University of New South Wales, University of Sydney.
Also from University of Virginia and Continuum Biosciences, published in Nature Communications.
