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New monoclonal antibody drug regrows lost teeth in ferrets


Key points from article :

A specific gene regulates the behavior of molecules known to be key players in tooth development.

Begins with pair of molecules called bone morphogenetic protein (BMP) and Wnt.

"Suppressing USAG-1 benefits tooth growth," - Katsu Takahashi, lead author.

Tested the effects of several monoclonal antibodies on USAG-1 in mice.

Led to one antibody that disrupted the interactions between USAG-1 and BMP only.

BMP signaling played an essential role in determining the number of teeth the mice ended up with.

Delivering one-off dose of the antibody resulted in the generation of an entire tooth.

Follow-up experiments in ferrets produced similar results.

"Our next plan is to test the antibodies on other animals such as pigs and dogs," - Takahashi.

Treatment one day becoming an effect approach to tackling congenital tooth agenesis.

Research by Kyoto University published in the journal Science Advances.

Promising tooth development approach for tooth anomalies after successful trials on pigs & dogs

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Associate Professor at Graduate School of Medicine, Kyoto University


Public Research university.


Scientific Journal