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Could diluting blood with recombinant serum albumin reverse ageing?

Disappointingly, no impact was observed on maximum lifespan - still looking for the next bridge

06-Apr-2021

Key points from article :

Life span of mice is extended by 20% after treatment every few weeks with serum albumin, beginning in mid-life.

Significant fraction of the issues arising with age are reactions to damaged albumin.

A single protein recombinant mouse serum albumin (rMSA) improved the lifespan and healthspan of mice.

The rMSA used in this study is young and almost undamaged.

Significantly extended lifespan with increased skeletal muscle strength and cognitive ability.

By delivering unmodified serum albumin, the harmful reactions diminish.

Interesting when considered in the context of the beneficial effects from dilution of blood in old animals.

Dilution protocol involves adding albumin, as albumin is one of the few essential items present in the bloodstream.

Further studies will be needed to clarify and replicate these results.

Study by the Tsinghua University published in the journal bioRxiv.

Mentioned in this article:

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bioRxiv

The preprint server for biology

Tsinghua University

Research university in Beijing, China

Topics mentioned on this page:
Young Blood