Key points from article :
Researchers hypothesize that increased ROS production by damaged mitochondria affects oocytes.
Mainly by causing genetic dysfuntion, leading to infertility and other problems.
Nicotinamide riboside (NR), NAD+ precursor, administered to 8-month-old female mice for 4 months.
Their NAD+ increased substantially over ordinary 12-month-old mice.
Follicle number, ovulation potential, oocyte count, ovary size, and litter size increased also.
But it did not fully return such fertility-related metrics to those of 2-month-old mice.
Supplementation of NR shown to promote healthy mitochondrial function, by increasing mitophagy.
It increases the expression of genes responsible for mitochondrial development.
Researchers from The First Affiliated Hospital of Zhengzhou University.
Also from Stanford University, published in Science.
