Key points from article :
Gut microbiome changes with age, shifting towards more harmful and fewer helpful microbes.
A self-experiment with flagellin immunization as an approach to adjust the gut microbiome.
Tested its ability to adjust the gut microbiome in mice, with favorable results.
Would human data be similar to the mouse data? The results here were on balance positive.
The self-experiment ran for ten weeks.
Weekly intramuscular injections of 10 μg flagellin with viome gut microbiome assays performed beforehand.
Subject was in the 45-50 age range, healthy and without chronic conditions, with a BMI of ~22.
Scores improved for inflammatory activity, digestive efficiency, gut lining Health, protein fermentation, and gas production.
Scores declined for metabolic fitness and active microbial diversity.
Gains were larger than the declines.
First few injections produced a minor injection site reaction.
Suggests to run a formal, controlled trial in older people, 65 and over.
