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CRISPR-edited stem cells promise rejection-free regenerative therapies

11-Jan-2024

Key points from article :

Scientists genetically modified pluripotent stem cells to avoid immune rejection.

This could enable stem cell-based therapies for diseases like Type 1 diabetes and macular degeneration.

Using CRISPR technology (genetic scissors), the team located and removed specific genes involved in immune rejection.

Modified stem cells were successfully persisted in mice with full-functioning immune systems.

"...a chance of being able to perform pluripotent stem cell-based transplants without immune suppressing the person." -Deepta Bhattacharya,  principal investigator.

Potential for "universal" stem cell lines applicable to many patients.

Next step involves testing the technology in animal models for Type 1 diabetes.

Clade Therapeutics to begin clinical trials by the end of the year for the treatment of cancer and autoimmune diseases.

Study by University of Arizona, published in Stem Cell Reports.

Genetically modified stem cells bypass immune rejection, paving way for universal therapies

Mentioned in this article:

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Clade Therapeutics

Cell therapy company developing novel cell-based medicines

Deepta Bhattacharya

Professor of Immunobiology and Surgery at the University of Arizona

Stem Cell Reports

Scientific Journal providing information about stem cells.

University of Arizona

Public Research university.

CRISPR-edited stem cells promise rejection-free regenerative therapies