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Treating Osteoarthritis by Removing Senescent Cells


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Researchers used local clearance of senescent cells (in mice) to reduce the development of post-traumatic osteoarthritis and encourage tissue regeneration.

Senescent cells accumulated in the articular cartilage and synovium after they induced anterior cruciate ligament injury.

Selective elimination of these cells reduced the development of osteoarthritis post injury, reduced pain and encouraged cartilage development.

Researchers used a compound called UBX0101 a senolytic drug created by Unity Biotechnology.

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UNITY Biotechnology

Biotechnology company devoted to research of restoring human health