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Scientists found a link to balance immunity and longevity

24-Jun-2020

Key points from article :

As we age, the immune system gradually becomes impaired.

One aspect of this impairment is chronic inflammation in the elderly.

Chronic inflammation is associated with arthritis and Alzheimer’s disease, and impaired immune responses.

Scientists discovered a change in an evolutionarily conserved gene called PUF60 in the tiny roundworm, Caenorhabditis elegans.

Worms with this change lived about 20% longer, but when infected, they succumbed more quickly to the infection.

An overactive immune system shortens life span.

Conversely, a less active immune system pays off as longer life span – as long as the animal does not die from an infection.

"Notably pinpointing how PUF60 activity affects immunity and longevity will be central to understanding the relationship between inflammation and ageing” - Adam Antebi, Lead author.

Research by Max Planck Institute for Biology of Ageing published in eLife.

Gene changes in round worm lead an interesting evidence to longevity

Mentioned in this article:

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Academic

Professor in Department of Molecular Genetics of Ageing at Max Planck Institute for Biology of Ageing.

Journal

Non-profit journal publishing work in all areas of biology and medicine

Institute

Scientific research institute dedicated to age research