Key points from article :
Rapamycin treatment (RT) to mammalian model organisms in late-life analyzed.
8 weeks of rapamycin in mice can confer an improvement in diastolic heart function.
This effect persisted for a further 8 weeks post-treatment.
Even after metabolic changes due to acute treatment reverted back to pre-treatment levels.
It could be useful for larger mammals as studied in dog cardiac outcomes.
10 weeks of RT improved measures of both systolic, diastolic cardiac function.
A critical goal of any pharmaceutical treatment is to minimize off-target effects.
Altering delivery from continuous to intermittent may help in animal models as well.
Positive effects of an intermittent RT can be separated from its side effects.
RT of 2mg/kg per day, every five days, beginning at 20 months of age in mice.
This could increase medial, maximal lifespan without bad effects on glucose homeostasis.
