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Inheritance of damaging mutations decides how long we get to live

10-Apr-2020

Key points from article :

Rare but damaging inherited mutations have a negative impact on healthspan and longevity.

A single inherited damaging mutation can reduce lifespan by 6 months.

Those who live long have fewer rarest protein truncating variants (PTVs) and less damaging PTVs.

Acquired accumulation of damaging PTVs are unlikely to contribute to ageing.

Increased frequency of PTVs has been linked to schizophrenia, epilepsy, and autism.

Analyzed genomic data from more than 40,000 people in mid-fifties registered in the UK Biobank.

Collaborative research published in eLife.

With whole exome and genome sequencing we could reveal so many secrets of life

Mentioned in this article:

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Academic

Instructor in Medicine at Harvard Medical School

Academic

Research Fellow at Harvard Medical School

Health Organisation

Teaching hospital of Harvard Medical School.

Journal

Non-profit journal publishing work in all areas of biology and medicine

Company

AI-powered platform for drug discovery and drug repurposing for age-related diseases.

Academia

Graduate medical school of Harvard University

Company Representative

Founder of Gero and physicist in drug discovery land.

Company

UK Biobank is a national and international health resource registered as a charity in Scotland

Academic

Professor of Medicine at Harvard Medical School.