Key points from article :
Rare but damaging inherited mutations have a negative impact on healthspan and longevity.
A single inherited damaging mutation can reduce lifespan by 6 months.
Those who live long have fewer rarest protein truncating variants (PTVs) and less damaging PTVs.
Acquired accumulation of damaging PTVs are unlikely to contribute to ageing.
Increased frequency of PTVs has been linked to schizophrenia, epilepsy, and autism.
Analyzed genomic data from more than 40,000 people in mid-fifties registered in the UK Biobank.
Collaborative research published in eLife.
