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Genes correlated for diseases with similar age at onset

UK Biobank study reveals genetic links & potential treatment strategies for age-related diseases

19-Apr-2021

Key points from article :

The first data-driven classification of multiple diseases obtained using human genetic and medical data from the UK Biobank.

"Understanding the molecular links between aging process and age-related diseases could allow them to be targeted with drugs to improve late-life health," - Linda Partridge, Study co-author.

"Diseases with a similar age of onset were genetically more similar to each other," - Partridge.

Data from the UK Biobank to investigate the genetic associations of 116 diseases.

Genetic links between diseases with the same onset profile suggesting a common cause.

The UK Biobank houses data from half a million UK participants and is openly available to researchers.

"If you really want to know about human aging you need access to human data," - Dame Janet Thornton, Co-lead researcher.

"These could potentially be targeted to prevent or treat groups of age-related diseases simultaneously," - Partridge.

Research by UCL and European Bioinformatics Institute published in Nature Aging.

Mentioned in this article:

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European Bioinformatics Institute

Bioinformatics research and services

Janet Thornton

Senior scientist and director emeritus at the European Bioinformatics Institute (EBI)

Linda Partridge

Professorial Research Fellow at UCL focusing on genetics, evolution & environment

Nature Aging

Journal spanning the entire spectrum of research into aging

University College London (UCL)

Diverse global community of world-class academics, students, industry links, external partners, and alumni

Topics mentioned on this page:
Longevity Genes, Ageing Research