Key points from article :
Pluripotent stem cells can develop into any cell or tissue in the human body.
They are useful in cell-based therapies, stem cell biobanks & clinical trials.
However, it’s been difficult to make large quantities of these stem cells without compromising the cells’ integrity.
Researchers have now developed a way to make large quantities of these cells that maintain their effectiveness.
There are two cell states in pluripotent stem cells — naïve and primed.
Primed are ones that have started to differentiate and the ones that haven’t are called naïve pluripotent stem cells.
“Primed stem cells do not grow efficiently in bioreactors. So, we converted them to naïve stem cells, which are more immature,” explains Dr. Leili Rohani.
Large quantities of the cells were in stirred-suspension bioreactors that help naïve stem cells stay in a stable state & allow effective production of large quantities of stem cells.
Research by McCaig Institute published in Communications Biology.