Key points from article :
Cellular senescence is a major determining factor for survival and therapeutic response in cervical cancer.
Survival and response to treatment correlates with the level of senescence related proteins in blood.
565 women with stage 2 & 3 cervical cancer who received internal radiation, external radiation or both were studied.
Internal radiation greatly improved survival in patients with high levels of these SASPs but not in those low levels.
Women with low levels of senescence-associated secreted phenotypes(SASP) had higher survival rates.
These proteins adversely affect neighbouring cells and other structural components.
“The most important conclusion...is you want to manage senescence to improve therapy for cervical cancer,” Dr. She, co author.
Research by Medical College of Georgia published in MDPI.
