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MIT professor Richard Young explains how Omega regulates gene expression

Using Epigenomic Controllers to alter DNA transcription rather than the genes themselves

01-Dec-2020

Key points from article :

Omega epigenomic controllers are designed to downregulate or upregulate the expression of 25,000+ human genes.

Human genome and its regulators are organized into Insulated Genomic Domains (IGDs).

Richard Young, professor of biology at MIT described about omega’s epigenomic programming platform.

Designed medicines using IGDs as drug targets to treat and cure disease.

Able to control gene expression without making changes in the DNA sequence.

Gene regulation could be selectively tuned to modify specific IGDs by using epigenetic modulation.

Precision genomic control bring the gene(s) back to the correct level.

Specificity and durability differentiates from gene therapy.

Effectively control multigenic and complex diseases with a single therapeutic intervention.

Epigenomic programming is tunable and durable, are not permanent.

Efficacious and potentially much safer than current gene therapy and gene editing approaches

Mentioned in this article:

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Omega Therapeutics

Designing, engineering and manufacturing Epigenomic Controllers

Richard Young

Professor at Whitehead Institute and MIT

Topics mentioned on this page:
Epigenetics, Gene Therapy