Join the club for FREE to access the whole archive and other member benefits.

Exercise reduces inflammation caused by SASP but not the number of senescent cells

Given senolytics are unlikely to ever clear every senescent cell, exercise will still minimise bad effects of those remaining

31-Jul-2020

Key points from article :

Accumulation of senescent cells with age is responsible for a sizable fraction of inflammatory signaling in tissues.

New study shows fitness training correlates with reduced inflammatory signaling but doesn't reduce the number of senescent cells in muscle tissue.

Likely explanation is that the cellular adaptations to exercise act to reduce harmful aspects as SASP.

Study looked at young/old sedentary/active males.

TIF levels (+35%) and SA-b-Gal positive cells (+30%) were higher in cells of older participants.

Independently of age, both trained groups had lower IL-8 mRNA levels (-70%) and lower TNF-alpha mRNA levels (-40%).

Endurance training status did not slow down senescence in skeletal muscle and satellite cells despite reduced inflammation in skeletal muscle.

Research by Université Catholique de Louvain published in American Journal of Physiology-Endocrinology and Metabolism.

Mentioned in this article:

Click on resource name for more details.

American Journal of Physiology - Endocrinology and Metabolism

Journal publishing original, mechanistic studies on the physiology of endocrine and metabolic systems

Université catholique de Louvain (UCLouvain)

Belgium's largest French-speaking university. World ranking for philosophy, theology and religious studies.

Topics mentioned on this page:
Senescent Cells, Exercise