Key points from article :
Analyzing glycans is a challenge, they're branched - so you cannot just read the letters in the way you read DNA or protein.
When we do the GlycanAge test, it focuses on the glycan immunoglobulins - we have to remove IGGs from the blood sample.
We have a special technology to get just IGG out of all other proteins in the sample.
Use capillary electrophoresis, or chromatography, which separates glycans based on their chemical structure.
The total glycome has approximately 2000 different glycan blocks - looking only at IGG reduces the number of glycans significantly.
After the antibody binds to this foreign object, what happens next is determined by glycans.
What we see in young people is that the majority of immunoglobulins have anti inflammatory glycans.
Methylation tests are a more accurate in predicting chronological age.
Analysis is simplified for biological age report:
One level is that we have three key indexes or scores, which is G0, G2, and GS.
- G0 are glycans without galactose, which are the most proinflammatory.
- G2 are glycans with two galactoses, which are suppressing inflammation.
- GS are glycans with sialic acid, which also suppress inflammation.
We use 150,000 results to build a model and to determine a person's GlycanAge.
Unpublished research into different diets show some people cope with glucose better than others.
We are hoping that GlycanAge can help people to focus on one of the four aspects which is dominant in them.
Loss of estrogen is extremely strong regulator of IGG glycosylation.
Overtraining also causes inflammation.
Pro-inflammatory markers usually change up to decade before people become ill.
Approximately 30-50% of the GlycanAge is determined by your genes, you cannot fix it - so don't worry about the absolute number.
Glycans change relatively slowly - we see things changing after three or four months.
GlycanAge is looking at the organism as a whole.
There is no standard human.
