Key points from article :
A new study from the University of Barcelona, published in Cell Stem Cell, shows that ageing neurons in mice can be rejuvenated through cellular reprogramming. Researchers used the Yamanaka factors—proteins known to reverse ageing in cells—to restore neuronal functions, enhancing their ability to form synaptic connections and improving metabolic stability. This breakthrough could offer new hope for treating neurodegenerative diseases like Alzheimer’s, where neuron ageing plays a critical role.
The study found that reprogrammed neurons exhibited increased synaptic plasticity and enhanced cognitive functions, such as improved memory and social interactions, without negative side effects. Additionally, this process protected neurons from neurodegeneration, suggesting it could be a valuable tool for combating age-related brain conditions.
By targeting the molecular mechanisms of ageing, this research opens exciting possibilities for developing therapies to reverse damage in the nervous system and explore treatments for both neurodevelopmental and neurodegenerative disorders.
