Key points from article :
University of Dundee demonstrate AdPROM to target and destroy specific proteins within cells.
Affinity-directed PROtein Missile uses small affinity probes which bind and recruit target proteins to the cellular protein degradation system to be destroyed.
In the majority of diseases protein function is altered due to genetic mutation or a deregulated environment.
During aging, proteins can become misfolded which leads to protein aggregation and the onset of diseases like Alzheimer’s.
The study was published in the Open Biology journal.
COMMENT: could also be used to target some of the SENS strategies such as LysoSENS
