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Senolytics staves off dementia in mice

Killing of senescent (aging) brain cells with an enzyme stopped the progress of dementia

19-Sep-2018

Key points from article :

Research in mice shows that senescent cells contribute to neurodegeneration.

Senescent cells accumulated in memory and cognition regions of the brain.

Treated by administering a genetically modified enzyme to clear senescent cells.

Outward symptoms of dementia vanished.

Animals retained the ability to form memories and eliminated signs of inflammation.

In the past decade evidence has emerged linking senescent cells to Parkinson’s disease.

Further work is needed to test whether the findings translate into patients.

The study was published in Nature journal.

Mentioned in this article:

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Darren Baker

Molecular biologist at Mayo Clinic.

James Pickett

Head of Research at Alzheimer's Society.

Mayo Clinic

Non-profit American academic medical center focused on health care, education, and research

Nature

Scientific journal covering research from a variety of academic disciplines, mostly in science and technology

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Senescent Cells