Join the club for FREE to access the whole archive and other member benefits.

Senolytics may have the potential to treat asthma

Will senolytics become the panacea to the whole Pandora's box by 100 years into future?

07-Apr-2020

Key points from article :

It is likely that senescent cells play a significant role in the development and progression of asthma.

Limited data has shown that cellular senescence is accelerated in asthma.

Considers azithromycin which belongs to the antibiotic group macrolide as a potential candidate.

Azithromycin removed 97% of senescent human lung fibroblasts in an in-vitro study.

Potential to reduce the senescence-associated secretory phenotype (SASP) in asthmatic lungs.

Potential to develop a repair-based therapy to treat asthma in the future.

Research by San Yat-sen University, published in Frontiers in Cell and Developmental Biology.

Mentioned in this article:

Click on resource name for more details.

Frontiers in Cell and Developmental Biology

Online perr-reviewed, open access journal

Sun Yat-sen University

University in Southern China

Topics mentioned on this page:
Senescent Cells, Respiratory Disease