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Umbilical cord blood derived plasma improves health biomarkers

Plasma concentrate alters methylation clock reducing biological age


Key points from article :

The aim of the study was to assess the safety of the treatment and multiple health biomarkers, including epigenetic age.

18 participants, with a mean age of 74 were given weekly intramuscular shots of plasma concentrate made from umbilical cord blood.

Markers of kidney function (creatinine and glomerular filtration rate) were greatly improved; no significant changes in lymphocyte numbers.

GrimAge, that predicts morbidity and mortality risk in humans, showed a significant reduction of biological age: 0.82 years on average.

Gene methylation of proteins cystatin C (kidney function) and GDF15 (cardiovascular and all-cause mortality) was altered.

A decreased Shannon entropy of methylation was observed; an increase in DNA methylation entropy means random methylation and demethylation.

To determine the extent of the benefits that plasma concentrate injections confer, more robust clinical trials are needed.

Intramuscular injections of plasma concentrate made from human umbilical cord blood improve various health biomarkers and decrease biological age in elderly people.

Researcher by University of Texas, Altos Labs, Epigenetic Clock Development Foundation7 and Better Humans.

Mentioned in this article:

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Altos Labs

Biotechnology company focused on cellular rejuvenation programming


Non-profit scientific research organization that studies the biology of aging and age-related diseases.

Clock Foundation

UCLA spin-out focussed on treatments that prolong health and life expectancy

University of Texas Health

A campus in University of Texas that consists of five schools to train healthcare professionals

Topics mentioned on this page:
Young Blood, Biological Age
Umbilical cord blood derived plasma improves health biomarkers