Key points from article :
The aim of the study was to assess the safety of the treatment and multiple health biomarkers, including epigenetic age.
18 participants, with a mean age of 74 were given weekly intramuscular shots of plasma concentrate made from umbilical cord blood.
Markers of kidney function (creatinine and glomerular filtration rate) were greatly improved; no significant changes in lymphocyte numbers.
GrimAge, that predicts morbidity and mortality risk in humans, showed a significant reduction of biological age: 0.82 years on average.
Gene methylation of proteins cystatin C (kidney function) and GDF15 (cardiovascular and all-cause mortality) was altered.
A decreased Shannon entropy of methylation was observed; an increase in DNA methylation entropy means random methylation and demethylation.
To determine the extent of the benefits that plasma concentrate injections confer, more robust clinical trials are needed.
Intramuscular injections of plasma concentrate made from human umbilical cord blood improve various health biomarkers and decrease biological age in elderly people.
Researcher by University of Texas, Altos Labs, Epigenetic Clock Development Foundation7 and Better Humans.