Key points from article :
Mitochondria (mt) can be ingested by cells and put to work.
Mitochondrial dysfunction substantially responsible for aging and age-related features.
Including decreased oxidative phosphorylation capability and increased ROS production.
Mitotherapy to transfer functional exogenous mt into mt-defective cells.
This is for cell viability recovery and disease progress prevention.
Systemic injection of isolated mitochondria could reduce liver injury.
Study administered young mt into aged mice to evaluate energy production increase.
And to see if age-related behaviors improved after the mitochondrial transplantation.
Results: heterozygous mtDNA of both aged and young mouse coexisted in aged mice tissues.
Also, ATP content in tissues increased while ROS level reduced.
It significantly improved cognitive and motor performance of aged mice.
Published in International Journal of Biological Sciences.
