Key points from article :
A study reports blood-DNA-methylation measure that detects variation in ageing pace.
The goal was to distill a measurement of the rate of biological ageing.
That is based on 12 years of follow-up on 18 different clinical tests into a blood test.
Midlife adults were measured to be ageing faster according to the new measurement.
Showed faster declines in physical, cognitive functioning, looked older in facial photographs.
Older adults measured to be ageing faster were at increased risk for chronic disease, mortality.
DunedinPoAm, their tool, captured new information not measured by epigenetic clocks.
Analyzed methylation marks on DNA from white blood cells.
A machine-learning technique called “elastic-net regression” was used.
It sifts through data on >400,000 different DNA methylation marks to analyze relationships.
Research by Columbia University Mailman School of Public Health and other co-author institutions.
Published in e-Life.
