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Life's curveballs can fast-forward your biological clock and make you look older

These age-jumps, measured by DNA changes, can actually reverse once the stressor fades

04-Jan-2024

Key points from article :

Stressful events like surgery, pregnancy, and COVID-19 can temporarily age your cells based on DNA methylation clocks.

Scientists at Harvard Medical School used a "blood-sharing" experiment in mice to show how young mice shared the older mice's biological age but reversed it after separation.

Human studies confirmed this: emergency surgery briefly increased biological age compared to elective surgery, and pregnancy followed the same pattern.

Even severe COVID-19 showed reversible age changes, especially in women and those treated with the drug tocilizumab.

This research suggests interventions targeting these "stress-aging" processes could improve health in older adults.

Future studies will explore how temporary stress-induced age changes impact overall aging throughout life.

The findings were published in Cell Metabolism.

Mentioned in this article:

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Cell Metabolism

Scientific Journal providing information from many different areas of metabolism

Harvard Medical School

Graduate medical school of Harvard University

Topics mentioned on this page:
Biological Age, Coronavirus
Life's curveballs can fast-forward your biological clock and make you look older