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Zoledronate - accidental discovery of drug use for life extension

30-Jun-2021

Key points from article :

Researchers have found that zoledronate (a biophosphonate), a drug that strengthens bones and reduce the risk of osteoporosis-related bone fractures, has unexpected life-extending properties in human beings.

They have confirmed these findings in a fruit fly study.

They found that the lower dose improved the lifespan of male flies but did not aid females.

When administered to middle-aged flies the drug increased lifespan in both males and females, similar to rapamycin.

The team found that this effects of the drug can be due to its inhibition of the farsenyl pyrophosphate synthase (FPPS) enzyme.

The drug also had benefits for the flies’ overall health.

This research is illuminating and provides a solid initial explanation for why zoledronate has the effects it does; however, these are only initial findings in a simple model of ageing.

Study by Sheffield University published in Journal of Gerontology:Series A.

Too early to tell whether off-patent drug's effects in fruit flies will be seen in humans

Mentioned in this article:

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Academic

Stem cell biologist and Co-Director of the Healthy Lifespan Institute at University of Sheffield.

Journal

Scientific journal covering the field of aging

Academia

Founded in 1828 as Sheffield School of Medicine, now it's ranked among first top 100 universities in the world