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Calorie restriction rejuvenates 'brain immune cells' in mice

Still one of the most reliable interventions when improving long-term health

27-May-2020

Key points from article :

Calorie restriction isn't a way to achieve meaningful rejuvenation in humans.

It produces a much greater impact on life span in short-lived mammals than in long-lived mammals.

Sex-specific functional states of microglia analyzed in vivo in mice.

Done in young adults, middle aged, and old wild type mice.

This is by means of multicolor two-photon imaging, using the microglial Ca2+ signaling.

Data revealed sex-specific differences in microglial Ca2+ signaling at all ages tested.

For both sexes, functional state of microglia changes at least twice in a lifespan.

6-12 months long caloric restriction counteracted these aging-induced change.

Shifting many but not all functional properties of microglia toward a younger phenotype.

Even short-term (6-week-long) caloric restriction beginning at old age had benefits.

It strongly improved microglial process motility, induced improved microglial Ca2+ signaling.

Researchers from Eberhard Karls University Tübingen, published in Frontiers in Immunology.

Mentioned in this article:

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Eberhard Karls University of Tubingen

Public Research university.

Frontiers in Immunology

Peer-reviewed Journal on Immunology

Topics mentioned on this page:
Calorie Restriction, Mental Health