Key points from article :
Researchers have identified changes in the ageing brain related to blood circulation.
Found that ventriculomegaly was associated with a lag in blood drainage from brain's deep region.
In healthy aging, time lag in circulation grows at almost same rate as enlarging ventricles.
But it begins slightly earlier, says findings of new study.
MRI that measures individual's lag between two drainage pathways might be a good biomarker.
They also examined people with traumatic brain injury (TBI).
Analysis showed a time lag in blood drainage that was related to the disease.
It is large in people who suffered TBI when they were young.
But much less for those who were injured later in life.
Timing asynchrony between two drainage might be the common mechanism underlying the condition.
This new biomarker might be useful for diagnosing, monitoring normal-pressure hydrocephalus.
Research by the RIKEN Center for Biosystems Dynamics Research, published in Brain.
