Key points from article :
Caloric restriction (CR), powerful and readily available anti-aging interventions.
Helps by lowering age-related inflammation and boosting healthy immune response.
Researchers evaluated the effect of long-term CR on the SA-T cells and on glucose tolerance.
They found that older mice weighed more and had more VAT than the younger ones.
Aged mice also suffered from impaired glucose tolerance and insulin resistance.
SA-T cells and VAT of aged and young obese mice on a high-fat diet showed same senescence phenotype.
Long-term CR subjected mice had lower body weight, less VAT, and and insulin resistance than normally fed mice.
CR in mice also significantly reduced the burden of SA-T cells in the VAT.
Then they depleted the number of SA-T cells in a new group of mice using PD-1 antibodies.
Antibody treatment also substantially decreased the expression levels of most proinflammatory cytokines in VAT.
Research by Keio University School of Medicine published in PLOS ONE.
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