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A new platform to identify cardiotoxic drug molecules


Key points from article :

Needs to grow heart cells in vitro so that drugs can be tested for cardiac toxicity.

But it's difficult to determine about the drug's effect on cardiac cells if they are not actually beating.

Biowire II is a platform that uses two elastic polymer wires three millimetres apart.

Every time the heart cells contract, the wires become bent.

Measuring the amount that the wires are bent by researchers can quantify the contraction of the cells.

Will help to identify cardiotoxic drugs even before they reach the market.

No need to wait till safety trials in humans to detect cardiotoxicity

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Professor & Canada Research Chair, Functional Cardiovascular Tissue Engineering


Public research university located in Toronto


Scientist at Institute of Biomaterials and Biomedical Engineering, University of Toronto