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Old skin transplants in young organisms reverses aging, show rejuvenation

01-Jul-2022

Key points from article :

Old human skin transplanted to young mice and witnessed a robust rejuvenation cascade that is probably triggered by vascular growth.

An immunocompromised mouse strain was used to prevent rejection and divided the animals into four study groups in addition to controls.

Transplanting old skin to a young organism reverses many features of skin aging.

Skin rejuvenation was also confirmed at the molecular level. 

Angiogenesis, the creation of new blood vessels, greatly increased four weeks after transplantation.

Vascular endothelial growth factor A (VEGF-A) treatment significantly improved various aging-related parameters.

Research by Technion Israel Institute of Technology  published in Science.

Upregulation of VEGF-A could be a potentially effective anti-aging therapy

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Science

Peer-reviewed academic online journal of the American Association for the Advancement of Science (AAAS)