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Vision loss due to age & glaucoma reversed in mice

David Sinclair says findings are 'transformative for the care of age-related vision diseases'


Key points from article :

Vision in mice restored by turning back the clock on aged retinal cells for a youthful gene function.

Adeno-associated virus (AAV) was used to deliver 3 gene (Oct4, Sox2 and Klf4) in mice retina.

The 3 genes along with a 4th one (not used in this work) are youth restoring - called Yamanaka factors.

Whole-body treatment of mice with the three-gene approach showed no negative side effects.

Promoted nerve regeneration in mice with damaged optic nerve & reversed vision loss in animals with glaucoma.

Also reversed vision loss in ageing animals without glaucoma.

First successful attempt to reverse glaucoma-induced vision loss, rather than merely stem its progression.

"..Possible to safely reverse the age of complex tissues such as the retina and restore its youthful biological function," - David Sinclair, HMS.

Could pave the way for therapies to promote tissue repair across various organs and reverse ageing.

Research by Harvard Medical School (HMS) published in Nature.

Mentioned in this article:

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David Sinclair

Harvard professor. Author of Lifespan.

Harvard Medical School

Graduate medical school of Harvard University


Scientific journal covering research from a variety of academic disciplines, mostly in science and technology

Topics mentioned on this page:
Vision (health), Rejuvenation