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Experimental drug reversed the fat build up in the liver

Tests done on animals suggest that CRMP reduces heart disease risk and animals didn't lose weight

02-Oct-2019

Key points from article :

CRMP makes the liver to waste energy, so the liver starts to use more than normal.

CRMP lets protons flow out of mitochondria without generating ATP.

Unlike dinitrophenol, CRMP affects mainly liver cells rather than the entire body.

Shulman wants to carry out further animal tests of CRMP before moving on to human trials.

Some subsequent trials might test CRMP in combination with existing drugs for type 2 diabetes.

Mentioned in this article:

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Gerald Shulman

Dr. Shulman is a professor of Medicine at Yale University

Yale University

Private Ivy League research university in New Haven, Connecticut

Topics mentioned on this page:
Diabetes, Mitochondria