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Nucleosome spacing of cell-free DNA reveals biological age

Always good to find a new biomarker of aging

21-Dec-2018

Key points from article :

Cell-free DNA (cfDNA) can reflect differences in the age and health of individuals.

Cell-free DNA (cfDNA) refers to naked DNA fragments that occur within the bloodstream.

cfDNA was taken from groups in their twenties, seventies and those over 100 years of age.

The eldest group was further subdivided into healthy and unhealthy individuals.

Nucleosome spacing of cfDNA differed depending on age and health status.

Spacing was regular in 20s group, but deteriorated with age.

Healthy aging results in epigenomic characteristics similar to those of younger individuals.

The study was published in the journal Aging Cell.

Mentioned in this article:

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Aging Cell

Scientific journal devoted to age related diseases

Nicola Neretti

Associate Professor of Molecular Biology, Cell Biolgy and Biochemistry at Brown University

Topics mentioned on this page:
Biological Age, DNA Testing