Key points from article :
Researchers from Delft University of Technology and Leiden University have developed a ground-breaking technique called SPARXS (Single-molecule Parallel Analysis for Rapid exploration of Sequence space), as published in the journal Science. This new method significantly speeds up the study of DNA molecules, allowing millions of them to be analysed in just a week, compared to the years required by traditional techniques. Professor Chirlmin Joo explains that SPARXS combines single-molecule fluorescence and next-generation Illumina sequencing to quickly explore vast DNA sequence libraries, revealing how DNA’s structure and function depend on its sequence.
Professor Joo anticipates that this advancement will lead to significant breakthroughs in genetic research, drug development, and biotechnology over the next five to ten years. By improving our ability to understand and manipulate DNA, SPARXS could pave the way for innovative medical treatments, such as more effective gene therapies and personalized medicine.
