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Reason analyses a new review paper on metformin - he's not keen

27-Sep-2019

Key points from article :

Reason is skeptical about the prominence that metformin receives.

Animal data is not great, the human data is a single study.

Effect size on life span is far too small to care about.

Detrimental side effects are large in comparison to that effect size.

National Institute on Aging Interventions Testing Program could not replicate early findings.

Metformin is associated with a higher risk of vitamin B12 and vitamin B6 deficiency.

Effects of exercise and the drug are not additive.

The study was published in Gerontology journal.

There have been more negative results in mice than positive - surprising given the press it gets

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Journal

Journal of Experimental, Clinical, Behavioural and Technological Gerontology.