Key points from article :
Pancreatic β cells generation from human pluripotent stem cells (hPSCs) employed in mice.
This holds promise as a cell replacement therapy for diabetes.
State of actin cytoskeleton, expression of pancreatic transcription factors link established.
Previously demonstrated that giving diabetic mice new β cells improve their condition.
Follow-up study has produced even more promising results by refining the technique.
SC-β cells from 4 hPSC lines exhibited dynamic glucose-stimulated insulin secretion.
Transplantation of islet-sized aggregates of these reversed severe preexisting diabetes.
New higher-quality β cells able to normalize blood sugar level in diabetic mice.
Subject's diabetes noted as “functionally cured” for a period of up to nine months.
Research by team from Washington University, published in Nature Biotechnology.
