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Immunotherapy as new approach to battle senescent cells

Successful in mice, it may help treat many age-related disease in human

23-Jun-2020

Key points from article :

New study have taken a CAR-T immunotherapy approach to removing senescent cells.

Identified urokinase-type plasminogen activator receptor (uPAR), as suitable target.

uPar is a cell-surface protein widely activated in senescent cells.

CAR T cells that target uPAR extend the survival of mice with lung adenocarcinoma.

These are mice that are treated with a senescence-inducing combination of drugs.

Also, it restored tissue homeostasis in mice with liver fibrosis induced chemically or by diet.

Results establish therapeutic potential of senolytic CAR T cells for senescence-associated diseases.

Researchers from Memorial Sloan Kettering Cancer Center, published in Nature.

Mentioned in this article:

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Memorial Sloan Kettering Cancer Center

Cancer treatment and research institution in New York City

Nature

Scientific journal covering research from a variety of academic disciplines, mostly in science and technology

Topics mentioned on this page:
Senescent Cells, Immunotherapy