Key points from article :
Eric Verdin - finding reliable biomarkers of aging
- need to work across tissues and populations
- two sexes age differently
- blood test average as many as 50 different cell types
- TRIIM trial' considerable epigenetic age reversal could be due to shifts in the population of T cells
Morgan Levine - Altos Labs
- biomarker of aging should be an independent predictor of morbidity and mortality
- want minimal variation in test-retest scores - traditional clock readings from the same sample can differ by as much as nine years
- team have developed a method of denoising existing clocks
Priyanka Joshi - co-founder of NeuroAge
- aggregated proteins fail to perform their functions
- company is working on a large postmortem cohort of about 2000 brains
- people with biological age younger than their chronological age were less likely to have developed Alzheimer’s
Sergio Ruiz - CEO of Turn.bio
- presented the company’s latest work on CAR T cell rejuvenation
- young cells renew the cellular environment
- focussing on immunology and dermatology for immediate commercialization
- hopes to begin Phase 1 and 2 clinical trials as early as 2024
Hanadie Yousef - CEO of Juvena Therapeutics
- has created a proprietary library of secreted proteins with therapeutic potential
- has 33 hits that can promote rejuvenation of various tissues
- uses unbiased quantitative proteomics and machine learning
Jennifer Garrison - assistant professor at Buck
- ovaries age 3.5 times faster than other organs
- while women on average live longer than men, their healthspan is shorter
- older age at menopause correlates with life expectancy - also in their brothers
- part of the Global Consortium for Reproductive Longevity and Equality (GCRLE)
Spring Behrouz and Andy Lee - founders of Vincere Therapeutics
- start-up company focused on mitochondrial dysfunction
- parkin enzyme tags malfunctioning mitochondria for recycling
- aims to create small molecules that would either aid parkin or block USP30
Marco Quarta - CEO of Rubedo
- a cell can be triggered into various states of senescence by different stressors
- employs a proprietary AI-driven platform
- based on single-cell technologies because bulk samples noisy
- one of Rubedo’s prodrugs nearly completely eliminated senescent cells with minimum to no damage to healthy cells
Matt Kaeberlein - University of Washington professor
- Dog Aging Project (DAP) is an open geroscience project
- more than 41,000 dogs enrolled in the DAP’s longitudinal arm
- one meal a day is associated with lower risk across a wide range of diseases
- Test of Rapamycin in Aging Dogs (TRIAD), which is about to begin
Ashley Zehnder - CEO of FaunaBio
- harnessing the mechanisms that make some species particularly long-lived
- particular focus on hibernation
- searching for the genes responsible for these amazing feats of evolution
Eric Morgen - founder of BioAge
- clinical-stage biotech with a portfolio of therapies that target the molecular causes of aging
- overarching goal is compression of morbidity
- uses a cohort of more than 10,000 patients to take longitudinal measurements of agin
- protein apelin is associated with longevity and muscle strength - candidate drug significantly prevented muscle atrophy
Yvonne Dotson and Stacie Walton - The Diversity Doctor
- discrimination faced by African-American women in the healthcare system
- undertreated for pain and are less likely to receive hormone replacement therapy after menopause
