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Super summary of 3rd Annual Longevity Therapeutics Summit

16-Feb-2021

Key points from article :

Anirvan Ghosh, Unity Biotechnology: clinical trial to determine the maximum safe single dose of its proprietary senolytic compound, UBX1325, that targets Bcl-xL.

Lloyd Klickstein, ResTORbio: phase 3 trial of BEZ235 did not meet its primary endpoint - potentially due to the different survey methods.

Ronald Kohanski, NIA: believes best time for anti-aging interventions is ~30 years old in humans.

Adam Freund, Calico: focused on IGF signaling through the inhibition of PAPP-A - may restore collagen deposition with age.

Gordon Lithgow, Buck Institute: using C. elegans for large-scale drug screening. Compressed morbidity seen with TFT, AKG & vit D.

Steven Braithwhite, Alkahest: Sifting plasma proteome. GRF6019 stalled cognitive decline in some patients with mild to moderate AD.

Aubrey de Grey, SENS Research Foundation: over a hundred startups in aging research, but field still in its infancy.

Reenie McCarthy, Stealth BioTherapeutics: Elamipretide normalizes mitochondrial morphology by reducing the production of toxic ROS.

Alex Zhavoronkov, Insilico: looking at link between cellular senescence and fibrosis.

Brian Culley, Lineage Cell Therapeutics: uses fully differentiated cell transplantation.

Marc Ramis-Castelltort, Rejuveron: funds and supports start-ups including Endogena, RejuverVas & RejuverSen.

Colin Watts, JuvLife: developing supplements - first may be a ketone ester.

Scott Shandler, Longevity Biotech: preclinical programs in neuroinflammation, diabetes & oncology.

Marco Quarta, Rubedo: creating prodrugs which are more stable and less toxic.

Andrei Gudkov, Genome Protection: anti-retrobiome vaccine demonstrated decreased frailty in mice.

Lewis Gruber, Siwa Therapeutics: claims monoclonal antibody 318H can be used against virtually all cancers.

Thomas Hughes, Navitor Pharmaceuticals: developed rapamycin analogs less toxic to mTORC2.

Samuel Agus, Biophytis: BIO101 normalizes angiotensin production, reduces hypertension, inflammation & fibrosis.

More and more companies making greater and greater progress - 2021 could be an exciting year

Mentioned in this article:

Company Representative

Principal Investigator at Calico

Academic

CEO of InSilico Medicine & Deep Longevity. CSO of Biogerontology Research Foundation.

Academic

Sr. Vice President, Basic Science at Roswell Park Cancer Institute.

Company Representative

Chief Executive Officer at UNITY Biotechnology.

Academic

Chief Science Officer at SENS Research Foundation. Author and advocate of ending ageing.

Company

Company focused on development of therapeutics that slow the degenerative processes associated with aging.

Company Representative

Mr. Culley occupies the position of President, CEO & Independent Director at Lineage Cell Therapeutics, Inc.

Company

Combating aging and associated diseases. An Alphabet (Google) subsidiary.

Company Representative

CEO at Juvenescence Life.

Company

Company developing and commercializing drugs for anti-aging applications capable of prolonging human health and life-span.

Academic

Professor at The Buck Institute

Company Representative

CEO, CSO and Co-Founder of SIWA Therapeutics

Company

Lineage is a clinical-stage biotechnology company developing novel cell therapies

Company Representative

Chief Innovation Officer at Adicet Bio, Inc.

Company

Company that develops a new class of therapeutics via artificial protein technology.

Company Representative

Co-Founder and CEO at Senolytic Therapeutics and Rejuveron.

Company Representative

Co-Founder CEO at Rubedo Life Sciences.

Institute

Conducting and supporting research on aging and the health and well-being of older people.

Company

Company developing medicines designed to target specific nutrient-sensing proteins to treat diseases.

Company Representative

CEO at Stealth BioTherapeutics.

Company

Company that develops and invests in drugs and technologies which prolong human lifespan.

Company

Biopharmaceutical company developing therapeutics for aging-related diseases.

Academic

Deputy Director of the Division of Aging Biology at the National Institute on Aging.

Company

Extending Health Span and Reverting Age-Related Diseases.

Company Representative

Chief Medical Officer at Biophytis.

Company Representative

Founder and CEO at Longevity Biotech.

Company

Biotechnology company producing therapy that targets and destroys senescent cells.

Company

Biopharmaceutical company focused on the discovery and commercialization of novel therapies..

Company Representative

CSO at Alkahest, Inc.

Company Representative

President and CEO at Navitor Pharmaceuticals.

Publisher

Biotechnology company devoted to research of restoring human health.