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Super summary of 3rd Annual Longevity Therapeutics Summit

16-Feb-2021

Key points from article :

Anirvan Ghosh, Unity Biotechnology: clinical trial to determine the maximum safe single dose of its proprietary senolytic compound, UBX1325, that targets Bcl-xL.

Lloyd Klickstein, ResTORbio: phase 3 trial of BEZ235 did not meet its primary endpoint - potentially due to the different survey methods.

Ronald Kohanski, NIA: believes best time for anti-aging interventions is ~30 years old in humans.

Adam Freund, Calico: focused on IGF signaling through the inhibition of PAPP-A - may restore collagen deposition with age.

Gordon Lithgow, Buck Institute: using C. elegans for large-scale drug screening. Compressed morbidity seen with TFT, AKG & vit D.

Steven Braithwhite, Alkahest: Sifting plasma proteome. GRF6019 stalled cognitive decline in some patients with mild to moderate AD.

Aubrey de Grey, SENS Research Foundation: over a hundred startups in aging research, but field still in its infancy.

Reenie McCarthy, Stealth BioTherapeutics: Elamipretide normalizes mitochondrial morphology by reducing the production of toxic ROS.

Alex Zhavoronkov, Insilico: looking at link between cellular senescence and fibrosis.

Brian Culley, Lineage Cell Therapeutics: uses fully differentiated cell transplantation.

Marc Ramis-Castelltort, Rejuveron: funds and supports start-ups including Endogena, RejuverVas & RejuverSen.

Colin Watts, JuvLife: developing supplements - first may be a ketone ester.

Scott Shandler, Longevity Biotech: preclinical programs in neuroinflammation, diabetes & oncology.

Marco Quarta, Rubedo: creating prodrugs which are more stable and less toxic.

Andrei Gudkov, Genome Protection: anti-retrobiome vaccine demonstrated decreased frailty in mice.

Lewis Gruber, Siwa Therapeutics: claims monoclonal antibody 318H can be used against virtually all cancers.

Thomas Hughes, Navitor Pharmaceuticals: developed rapamycin analogs less toxic to mTORC2.

Samuel Agus, Biophytis: BIO101 normalizes angiotensin production, reduces hypertension, inflammation & fibrosis.

More and more companies making greater and greater progress - 2021 could be an exciting year

Mentioned in this article:

Click on resource name for more details.

Adam Freund

Principal Investigator at Calico

Alex Zhavoronkov

CEO of InSilico Medicine & Deep Longevity. CSO of Biogerontology Research Foundation.

Alkahest

Biotechnology company focused on treating neurodegenerative and other age-related diseases

Andrei Gudkov

Sr. Vice President, Basic Science at Roswell Park Cancer Institute.

Anirvan Ghosh

Chief Executive Officer at UNITY Biotechnology.

Aubrey de Grey

President and Chief Science Officer at Longevity Escape Velocity (LEV) Foundation

Biophytis

Company focused on development of therapeutics that slow the degenerative processes associated with aging.

Brian M. Culley

Mr. Culley occupies the position of President, CEO & Independent Director at Lineage Cell Therapeutics, Inc.

Buck Institute

Independent biomedical research institute focused on aging

Calico

Combating aging and associated diseases. An Alphabet (Google) subsidiary.

Colin Watts

CEO at Juvenescence Life.

Genome Protection

Company developing and commercializing drugs for anti-aging applications capable of prolonging human health and life-span.

Gordon Lithgow

Professor at The Buck Institute

Insilico Medicine

Biotechnology company that uses artificial intelligence to develop new drugs and for aging research

Lewis Gruber

CEO, CSO and Co-Founder of SIWA Therapeutics

Lineage Cell Therapeutics

Lineage is a clinical-stage biotechnology company developing novel cell therapies

Lloyd Klickstein

Chief Innovation Officer at Adicet Bio, Inc.

Longevity Biotech

Company that develops a new class of therapeutics via artificial protein technology.

Marc Ramis-Castelltort

Co-Founder and CEO at Senolytic Therapeutics and Rejuveron.

Marco Quarta

Co-Founder CEO at Rubedo Life Sciences.

National Institute on Aging (NIA)

Conducting and supporting research on aging and the health and well-being of older people.

Navitor Pharmaceuticals

Company developing medicines designed to target specific nutrient-sensing proteins to treat diseases.

Reenie McCarthy

CEO at Stealth BioTherapeutics.

Rejuveron

Company that develops and invests in drugs and technologies which prolong human lifespan.

resTORbio

Biopharmaceutical company developing therapeutics for aging-related diseases.

Ronald Kohanski

Deputy Director of the Division of Aging Biology at the National Institute on Aging.

Rubedo Life Sciences

Extending Health Span and Reverting Age-Related Diseases.

Samuel Agus

Chief Medical Officer at Biophytis.

Scott Shandler

Founder and CEO at Longevity Biotech.

SENS Research Foundation

Non-profit organization focused on transforming the way the world researches and treats age-related diseases

SIWA Therapeutics

Biotechnology company producing therapy that targets and destroys senescent cells.

Stealth BioTherapeutics

Biopharmaceutical company focused on the discovery and commercialization of novel therapies..

Steven Braithwaite

CSO at Alkahest, Inc.

Thomas E. Hughes

President and CEO at Navitor Pharmaceuticals.

UNITY Biotechnology

Biotechnology company devoted to research of restoring human health