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Cardiac glycosides may play a role as broad spectrum senolytics

Is it really possible to develop a drug without side effects?

21-Oct-2019

Key points from article :

Existing senolytic drugs that can be used as cancer therapy also kill immune cells.

Need to identify alternative drugs that can eliminate senescent cells.

Ouabain is a drug in cardiac glycoside group such as digoxin that can be used as a senolytic.

Can selectively eliminate many types of senescent cells.

Even when senescence has been triggered by irradiation, cancer itself or chemotherapeutic drugs.

Research by Medical Research Council London Institute of Medical Sciences published in Nature Metabolism.

Mentioned in this article:

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Jesús Gil

Scientist at MRC London Institute of Medical Sciences that works on senolytics and cancer therapy

Medical Research Council London Institute of Medical Sciences

An institution that trains clinical and non-clinical scientists to cater to public health nrequirements

Nature Metabolism

Online journal Nature Metabolism is an online journal of Nature Research

Topics mentioned on this page:
Senescent Cells