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Josh Mitteldorf plans to self-experiment with high dosages of spermidine

Backed by science, this natural compound may be the key to living longer and better.

07-May-2024

Key points from article :

Spermidine is a natural molecule found in many foods that declines with age.

Supplementing spermidine may increase lifespan and healthspan in various species and lower mortality in humans.

It may work by enhancing autophagy, the recycling of damaged cell parts, and reducing overactive cell death.

It may also have anti-inflammatory properties and benefits for brain function and immunity.

Foods high in spermidine include wheat germ, soy products, mushrooms, and some cheeses.

Effective dosage for humans is unclear, current supplements may not be strong enough.

Studies suggest potential benefits but more human research is needed.

The author plans to self-experiment with spermidine based on promising results in animal studies.

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Josh Mitteldorf

Evolutionary biologist and author of the Playing the Game for a Longer Life blog

Topics mentioned on this page:
Supplements, Autophagy
Josh Mitteldorf plans to self-experiment with high dosages of spermidine