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Has Metformin received too much of an attention as an anti ageing drug?

14-Jan-2021

Key points from article :

Although current research gives promise to metformin as an anti-aging drug, there are still concerns.

Changes in dosage turning the result from life-extending to life-ending.

About 25% of patients treated with metformin have gastrointestinal side effects.

Chronic use causes vitamin B12 deficiency.

Gender influences drug effectiveness.

Metformin in Longevity Study (MILES) - 14 people aged >70 randomised to take metformin for 6 weeks. Glucose Lowering In Non-diabetic hyperglycaemia Trial (GLINT) will evaluate the performance of metformin in reducing CVD risks

The Targeting Aging with Metformin (TAME) trial - designed to enrol 3000 subjects.

Test whether metformin delays age-related diseases.

The TAME trial may make metformin the first approved drug for anti-aging.

The shift in the notion of aging will enable future anti-aging clinical to trials proceed with much more ease.

Studies show promise with metformin - tiny positive outcomes with side effects