Eating less activates the gene OXR1 which controls brain ageing and lifespan

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Scientists at the Buck Institute have uncovered a gene that holds the potential to extend lifespan and slow brain aging.

They found that eating less activates this gene, called OXR1, which helps recycle cell materials and protect neurons from damage.

Their research, conducted on both fruit flies and human cells, suggests that dietary restriction may boost OXR1 levels, offering a potential explanation for its lifespan-extending effects.

OXR1 is also linked to the retromer complex, which is involved in recycling cellular proteins and lipids.

Dysfunction of this complex is associated with neurodegenerative diseases like Alzheimer's and Parkinson's, and OXR1 appears to play a protective role.

The team is now focused on developing therapies that mimic the brain-protective effects of dietary restriction by targeting OXR1.

Their findings, published in Nature Communications, offer exciting possibilities for slowing brain aging and combating age-related neurodegenerative diseases.