Key points from article :
CALERIE multi-centre trial tested 200 healthy, non-obese adults over 2 years.
State-of-the-art metabolic chambers measure oxygen use and CO2 exhalation.
Reducing calorie intake by 15% mapped to more energy efficient sleeping.
Other clinical measurements were in line with reduced metabolic rate.
Evidence that results in other animals can be applied to ourselves.
The study was published in the Cell Metabolism journal.
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