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OTC drug Ibuprofen could reverse age associated inflammation


Key points from article :

Inflammation is a central pillar of age-related morbidity and mortality, biological aging and many age-related diseases.

Scientists have created a mouse model with genetically enhanced NF-𝚔B activity which predisposed them to inflammation and premature aging.

In the areas of the brain associated with memory – the hippocampus and cerebellum – senescent cells were found.

Senescent cells express inflammation-associated genes that can damage the surrounding tissues.

Long term treatment with ibuprofen, an over the counter non-steroidal anti-inflammatory drug reduce markers of senescence in neurons as well as brain inflammation in these aging mice.

Ibuprofen inhibits cyclooxygenase enzyme COX-2 to reduce the detrimental effect that aging has on cognition.

Abundance of data supporting its safe use, so using it to counter inflammaging would be good news for longevity.

Research by Biosciences Institute for Ageing Research, at Newcastle University, published in Aging cell.

A study on mice supported ibuprofen for use in neurodegenerative diseases

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Aging Cell

Scientific Journal devoted to age related diseases.

Newcastle University

Public world-class research-intensive University based in the North East of England