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A cellular protein called HKDC1 tidies up mitochondria and lysosomes

This discovery paves the way for potential anti-ageing therapies

01-Jan-2024

Key points from article :

Inside our cells, tiny "organelles" like mitochondria (powerhouse) and lysosomes (cleaners) are crucial for health, but damage can lead to aging and disease.

Scientists at Osaka University discovered a protein called HKDC1 that helps care for these organelles, especially when they're stressed.

HKDC1 is linked to a protein called TFEB, which helps repair stress in both mitochondria and lysosomes.

HKDC1 plays a part in "mitophagy," the process of removing damaged mitochondria, and helps lysosomes repair themselves.

This dual role in protecting both key organelles could lead to new treatments for aging and related diseases.

The research was published in a scientific journal called Proceedings of the National Academy of Sciences (PNAS).

Mentioned in this article:

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Osaka University

Public Research university.

Proceedings of the National Academy of Sciences (PNAS)

Multidisciplinary scientific journal, official journal of the National Academy of Sciences

Topics mentioned on this page:
Ageing Research, Mitochondria
A cellular protein called HKDC1 tidies up mitochondria and lysosomes